Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing

Therapeutic targets of CRISPR-Cas can often not be accessed due to lack of carriers to deliver RNPs systematically. Here, the authors engineer modified lipid nanoparticles for delivery of gene editing proteins to specific tissues.

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Auteurs principaux:	Tuo Wei, Qiang Cheng, Yi-Li Min, Eric N. Olson, Daniel J. Siegwart
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/643f6e049bbd4fa2a9c4925cf329f370
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spelling	oai:doaj.org-article:643f6e049bbd4fa2a9c4925cf329f3702021-12-02T17:12:24ZSystemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing10.1038/s41467-020-17029-32041-1723https://doaj.org/article/643f6e049bbd4fa2a9c4925cf329f3702020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17029-3https://doaj.org/toc/2041-1723Therapeutic targets of CRISPR-Cas can often not be accessed due to lack of carriers to deliver RNPs systematically. Here, the authors engineer modified lipid nanoparticles for delivery of gene editing proteins to specific tissues.Tuo WeiQiang ChengYi-Li MinEric N. OlsonDaniel J. SiegwartNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tuo Wei Qiang Cheng Yi-Li Min Eric N. Olson Daniel J. Siegwart Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
description	Therapeutic targets of CRISPR-Cas can often not be accessed due to lack of carriers to deliver RNPs systematically. Here, the authors engineer modified lipid nanoparticles for delivery of gene editing proteins to specific tissues.
format	article
author	Tuo Wei Qiang Cheng Yi-Li Min Eric N. Olson Daniel J. Siegwart
author_facet	Tuo Wei Qiang Cheng Yi-Li Min Eric N. Olson Daniel J. Siegwart
author_sort	Tuo Wei
title	Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
title_short	Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
title_full	Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
title_fullStr	Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
title_full_unstemmed	Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
title_sort	systemic nanoparticle delivery of crispr-cas9 ribonucleoproteins for effective tissue specific genome editing
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/643f6e049bbd4fa2a9c4925cf329f370
work_keys_str_mv	AT tuowei systemicnanoparticledeliveryofcrisprcas9ribonucleoproteinsforeffectivetissuespecificgenomeediting AT qiangcheng systemicnanoparticledeliveryofcrisprcas9ribonucleoproteinsforeffectivetissuespecificgenomeediting AT yilimin systemicnanoparticledeliveryofcrisprcas9ribonucleoproteinsforeffectivetissuespecificgenomeediting AT ericnolson systemicnanoparticledeliveryofcrisprcas9ribonucleoproteinsforeffectivetissuespecificgenomeediting AT danieljsiegwart systemicnanoparticledeliveryofcrisprcas9ribonucleoproteinsforeffectivetissuespecificgenomeediting
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Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing

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