Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing

Therapeutic targets of CRISPR-Cas can often not be accessed due to lack of carriers to deliver RNPs systematically. Here, the authors engineer modified lipid nanoparticles for delivery of gene editing proteins to specific tissues.

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Bibliographic Details
Main Authors: Tuo Wei, Qiang Cheng, Yi-Li Min, Eric N. Olson, Daniel J. Siegwart
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/643f6e049bbd4fa2a9c4925cf329f370
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