Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5

Eg5 has a role in spindle assembly and has been associated with tumorigenesis but it is not clear how its activity is regulated. Here, the authors show that the E3 ligase RNF20/40 regulates mitotic spindle assembly by regulating the stability of Eg5 through mono-ubiquitination of K745.

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Autores principales:	Yang Duan, Dawei Huo, Jie Gao, Heng Wu, Zheng Ye, Zhe Liu, Kai Zhang, Lin Shan, Xing Zhou, Yue Wang, Dongxue Su, Xiang Ding, Lei Shi, Yan Wang, Yongfeng Shang, Chenghao Xuan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6442b2c4a6ff46e485d617184856d10d
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spelling	oai:doaj.org-article:6442b2c4a6ff46e485d617184856d10d2021-12-02T14:38:57ZUbiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg510.1038/ncomms126482041-1723https://doaj.org/article/6442b2c4a6ff46e485d617184856d10d2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12648https://doaj.org/toc/2041-1723Eg5 has a role in spindle assembly and has been associated with tumorigenesis but it is not clear how its activity is regulated. Here, the authors show that the E3 ligase RNF20/40 regulates mitotic spindle assembly by regulating the stability of Eg5 through mono-ubiquitination of K745.Yang DuanDawei HuoJie GaoHeng WuZheng YeZhe LiuKai ZhangLin ShanXing ZhouYue WangDongxue SuXiang DingLei ShiYan WangYongfeng ShangChenghao XuanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yang Duan Dawei Huo Jie Gao Heng Wu Zheng Ye Zhe Liu Kai Zhang Lin Shan Xing Zhou Yue Wang Dongxue Su Xiang Ding Lei Shi Yan Wang Yongfeng Shang Chenghao Xuan Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5
description	Eg5 has a role in spindle assembly and has been associated with tumorigenesis but it is not clear how its activity is regulated. Here, the authors show that the E3 ligase RNF20/40 regulates mitotic spindle assembly by regulating the stability of Eg5 through mono-ubiquitination of K745.
format	article
author	Yang Duan Dawei Huo Jie Gao Heng Wu Zheng Ye Zhe Liu Kai Zhang Lin Shan Xing Zhou Yue Wang Dongxue Su Xiang Ding Lei Shi Yan Wang Yongfeng Shang Chenghao Xuan
author_facet	Yang Duan Dawei Huo Jie Gao Heng Wu Zheng Ye Zhe Liu Kai Zhang Lin Shan Xing Zhou Yue Wang Dongxue Su Xiang Ding Lei Shi Yan Wang Yongfeng Shang Chenghao Xuan
author_sort	Yang Duan
title	Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5
title_short	Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5
title_full	Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5
title_fullStr	Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5
title_full_unstemmed	Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5
title_sort	ubiquitin ligase rnf20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein eg5
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6442b2c4a6ff46e485d617184856d10d
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Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5

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