Relationship of Dickkopf1 (DKK1) with cardiovascular disease and bone metabolism in Caucasian type 2 diabetes mellitus.

<h4>Objectives</h4>Dickkopf-1 (DKK1) is a potent inhibitor of Wnt signalling, which exerts anabolic effects on bone and also takes part in the regulation of vascular cells. Our aims were to evaluate serum DKK1 in type 2 diabetes (T2DM) patients and to analyze its relationships with cardi...

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Autores principales:	Antonia Garcia-Martín, Rebeca Reyes-Garcia, Beatriz García-Fontana, Sonia Morales-Santana, Ana Coto-Montes, Manuel Muñoz-Garach, Pedro Rozas-Moreno, Manuel Muñoz-Torres
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/644306ce613a4d35815a9402ce77a0e1
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spelling	oai:doaj.org-article:644306ce613a4d35815a9402ce77a0e12021-11-25T05:54:41ZRelationship of Dickkopf1 (DKK1) with cardiovascular disease and bone metabolism in Caucasian type 2 diabetes mellitus.1932-620310.1371/journal.pone.0111703https://doaj.org/article/644306ce613a4d35815a9402ce77a0e12014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0111703https://doaj.org/toc/1932-6203<h4>Objectives</h4>Dickkopf-1 (DKK1) is a potent inhibitor of Wnt signalling, which exerts anabolic effects on bone and also takes part in the regulation of vascular cells. Our aims were to evaluate serum DKK1 in type 2 diabetes (T2DM) patients and to analyze its relationships with cardiovascular disease (CVD). We also evaluated the relationship between DKK1 and bone metabolism.<h4>Design</h4>We conducted a cross-sectional study in which we measured serum DKK1 (ELISA, Biomedica) in 126 subjects: 72 patients with T2DM and 54 non-diabetic subjects. We analysed its relationship with clinical CVD, preclinical CVD expressed as carotid intima media thickness (IMT), and bone metabolism.<h4>Results</h4>T2DM patients with CVD (P = 0,026) and abnormal carotid IMT (P = 0,038) had higher DKK1 concentrations. DKK1 was related to the presence of CVD in T2DM, independently of the presence of risk factors for atherosclerosis. Therefore, for each increase of 28 pg/ml of serum DKK1 there was a 6,2% increase in the risk of CVD in T2DM patients. The ROC curve analysis to evaluate the usefulness of DKK1 as a marker for high risk of CVD showed an area under the curve of 0,667 (95% CI: 0,538-0,795; P = 0,016). In addition, there was a positive correlation between serum DKK1 and spine bone mineral density in the total sample (r = 0,183; P = 0,048).<h4>Conclusion</h4>In summary, circulating DKK1 levels are higher in T2DM with CVD and are associated with an abnormal carotid IMT in this cross-sectional study. DKK1 may be involved in vascular disease of T2DM patients.Antonia Garcia-MartínRebeca Reyes-GarciaBeatriz García-FontanaSonia Morales-SantanaAna Coto-MontesManuel Muñoz-GarachPedro Rozas-MorenoManuel Muñoz-TorresPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 11, p e111703 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antonia Garcia-Martín Rebeca Reyes-Garcia Beatriz García-Fontana Sonia Morales-Santana Ana Coto-Montes Manuel Muñoz-Garach Pedro Rozas-Moreno Manuel Muñoz-Torres Relationship of Dickkopf1 (DKK1) with cardiovascular disease and bone metabolism in Caucasian type 2 diabetes mellitus.
description	<h4>Objectives</h4>Dickkopf-1 (DKK1) is a potent inhibitor of Wnt signalling, which exerts anabolic effects on bone and also takes part in the regulation of vascular cells. Our aims were to evaluate serum DKK1 in type 2 diabetes (T2DM) patients and to analyze its relationships with cardiovascular disease (CVD). We also evaluated the relationship between DKK1 and bone metabolism.<h4>Design</h4>We conducted a cross-sectional study in which we measured serum DKK1 (ELISA, Biomedica) in 126 subjects: 72 patients with T2DM and 54 non-diabetic subjects. We analysed its relationship with clinical CVD, preclinical CVD expressed as carotid intima media thickness (IMT), and bone metabolism.<h4>Results</h4>T2DM patients with CVD (P = 0,026) and abnormal carotid IMT (P = 0,038) had higher DKK1 concentrations. DKK1 was related to the presence of CVD in T2DM, independently of the presence of risk factors for atherosclerosis. Therefore, for each increase of 28 pg/ml of serum DKK1 there was a 6,2% increase in the risk of CVD in T2DM patients. The ROC curve analysis to evaluate the usefulness of DKK1 as a marker for high risk of CVD showed an area under the curve of 0,667 (95% CI: 0,538-0,795; P = 0,016). In addition, there was a positive correlation between serum DKK1 and spine bone mineral density in the total sample (r = 0,183; P = 0,048).<h4>Conclusion</h4>In summary, circulating DKK1 levels are higher in T2DM with CVD and are associated with an abnormal carotid IMT in this cross-sectional study. DKK1 may be involved in vascular disease of T2DM patients.
format	article
author	Antonia Garcia-Martín Rebeca Reyes-Garcia Beatriz García-Fontana Sonia Morales-Santana Ana Coto-Montes Manuel Muñoz-Garach Pedro Rozas-Moreno Manuel Muñoz-Torres
author_facet	Antonia Garcia-Martín Rebeca Reyes-Garcia Beatriz García-Fontana Sonia Morales-Santana Ana Coto-Montes Manuel Muñoz-Garach Pedro Rozas-Moreno Manuel Muñoz-Torres
author_sort	Antonia Garcia-Martín
title	Relationship of Dickkopf1 (DKK1) with cardiovascular disease and bone metabolism in Caucasian type 2 diabetes mellitus.
title_short	Relationship of Dickkopf1 (DKK1) with cardiovascular disease and bone metabolism in Caucasian type 2 diabetes mellitus.
title_full	Relationship of Dickkopf1 (DKK1) with cardiovascular disease and bone metabolism in Caucasian type 2 diabetes mellitus.
title_fullStr	Relationship of Dickkopf1 (DKK1) with cardiovascular disease and bone metabolism in Caucasian type 2 diabetes mellitus.
title_full_unstemmed	Relationship of Dickkopf1 (DKK1) with cardiovascular disease and bone metabolism in Caucasian type 2 diabetes mellitus.
title_sort	relationship of dickkopf1 (dkk1) with cardiovascular disease and bone metabolism in caucasian type 2 diabetes mellitus.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/644306ce613a4d35815a9402ce77a0e1
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Relationship of Dickkopf1 (DKK1) with cardiovascular disease and bone metabolism in Caucasian type 2 diabetes mellitus.

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