Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding

The folding of protein domains can occur concomitant with their synthesis, and the rates at which individual codons are translated by the ribosome can affect the folding process. Here the authors present a kinetic model that accurately predicts the probability that a nascent protein domain will co-t...

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Autores principales:	Daniel A. Nissley, Ajeet K. Sharma, Nabeel Ahmed, Ulrike A. Friedrich, Günter Kramer, Bernd Bukau, Edward P. O’Brien
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/644393080ecd46ffb8ae9c3eca310651
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spelling	oai:doaj.org-article:644393080ecd46ffb8ae9c3eca3106512021-12-02T16:49:25ZAccurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding10.1038/ncomms103412041-1723https://doaj.org/article/644393080ecd46ffb8ae9c3eca3106512016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10341https://doaj.org/toc/2041-1723The folding of protein domains can occur concomitant with their synthesis, and the rates at which individual codons are translated by the ribosome can affect the folding process. Here the authors present a kinetic model that accurately predicts the probability that a nascent protein domain will co-translationally fold in vivo.Daniel A. NissleyAjeet K. SharmaNabeel AhmedUlrike A. FriedrichGünter KramerBernd BukauEdward P. O’BrienNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel A. Nissley Ajeet K. Sharma Nabeel Ahmed Ulrike A. Friedrich Günter Kramer Bernd Bukau Edward P. O’Brien Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding
description	The folding of protein domains can occur concomitant with their synthesis, and the rates at which individual codons are translated by the ribosome can affect the folding process. Here the authors present a kinetic model that accurately predicts the probability that a nascent protein domain will co-translationally fold in vivo.
format	article
author	Daniel A. Nissley Ajeet K. Sharma Nabeel Ahmed Ulrike A. Friedrich Günter Kramer Bernd Bukau Edward P. O’Brien
author_facet	Daniel A. Nissley Ajeet K. Sharma Nabeel Ahmed Ulrike A. Friedrich Günter Kramer Bernd Bukau Edward P. O’Brien
author_sort	Daniel A. Nissley
title	Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding
title_short	Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding
title_full	Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding
title_fullStr	Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding
title_full_unstemmed	Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding
title_sort	accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/644393080ecd46ffb8ae9c3eca310651
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Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding

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