Sex differences in obesity and cognitive function in a cognitively normal aging Chinese Han population

Wei Li,* Qi Qiu,* Lin Sun, Ling Yue, Tao Wang, Xia Li, Shifu Xiao Alzheimer’s Disease and Related Disorders Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China *These authors contributed equally to&nb...

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Autores principales:	Li W, Qiu Q, Sun L, Yue L, Wang T, Li X, Xiao S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	sex difference obesity cognition lipids Chinese elderly Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/6448c9c2ca524fd3968dd81c8ff5b062
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spelling	oai:doaj.org-article:6448c9c2ca524fd3968dd81c8ff5b0622021-12-02T07:29:14ZSex differences in obesity and cognitive function in a cognitively normal aging Chinese Han population1178-2021https://doaj.org/article/6448c9c2ca524fd3968dd81c8ff5b0622017-09-01T00:00:00Zhttps://www.dovepress.com/sex-differences-in-obesity-and-cognitive-function-in-a-cognitively-nor-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Wei Li,* Qi Qiu,* Lin Sun, Ling Yue, Tao Wang, Xia Li, Shifu Xiao Alzheimer’s Disease and Related Disorders Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China *These authors contributed equally to this work Background: Sex differences in Alzheimer’s disease and mild cognitive impairment have been well recognized. However, sex differences in cognitive function and obesity in cognitively normal aging Chinese Han population have not attracted much attention. Objective: The aim of this study was to investigate the relationship between sex, obesity, and cognitive function in an elderly Chinese population with normal cognitive function. Subjects and methods: A total of 228 cognitively normal aging participants (males/females =93/135) entered this study. Their general demographic information (sex, age, and education) was collected by standardized questionnaire. Apolipoprotein E (APOE) genotype and serum lipid levels were measured. The Montreal Cognitive Assessment (MoCA) was used to assess participants’ cognitive function. Results: The prevalence of obesity in elderly women (18/133, 13.5%) was significantly higher than that in men (5/92, 5.4%, P=0.009). Regression analyses showed that obesity was associated with drinking alcohol (OR =13.695, P=0.045) and triglyceride (OR =1.436, P=0.048) in women and limited to low-density lipoprotein (OR =11.829, P=0.023) in men. Women performed worse on the naming score for MoCA than men (P<0.01). Stepwise linear regression analysis showed that education (t=3.689, P<0.001) and smoking (t=2.031, P=0.045) were related to the score of naming in female, while high-density lipoprotein (t=–2.077, P=0.041) was related to the score of naming in male; however, no correlation was found between body mass index and cognitive function in both male and female (P>0.05). Conclusion: Our finding suggests that there are significant sex differences in obesity and specific cognitive domains in aging Chinese Han population with normal cognitive function. Keywords: sex difference, obesity, cognitive function, lipids, elderly ChineseLi WQiu QSun LYue LWang TLi XXiao SDove Medical Pressarticlesex differenceobesitycognitionlipidsChinese elderlyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2405-2410 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	sex difference obesity cognition lipids Chinese elderly Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	sex difference obesity cognition lipids Chinese elderly Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Li W Qiu Q Sun L Yue L Wang T Li X Xiao S Sex differences in obesity and cognitive function in a cognitively normal aging Chinese Han population
description	Wei Li,* Qi Qiu,* Lin Sun, Ling Yue, Tao Wang, Xia Li, Shifu Xiao Alzheimer’s Disease and Related Disorders Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China *These authors contributed equally to this work Background: Sex differences in Alzheimer’s disease and mild cognitive impairment have been well recognized. However, sex differences in cognitive function and obesity in cognitively normal aging Chinese Han population have not attracted much attention. Objective: The aim of this study was to investigate the relationship between sex, obesity, and cognitive function in an elderly Chinese population with normal cognitive function. Subjects and methods: A total of 228 cognitively normal aging participants (males/females =93/135) entered this study. Their general demographic information (sex, age, and education) was collected by standardized questionnaire. Apolipoprotein E (APOE) genotype and serum lipid levels were measured. The Montreal Cognitive Assessment (MoCA) was used to assess participants’ cognitive function. Results: The prevalence of obesity in elderly women (18/133, 13.5%) was significantly higher than that in men (5/92, 5.4%, P=0.009). Regression analyses showed that obesity was associated with drinking alcohol (OR =13.695, P=0.045) and triglyceride (OR =1.436, P=0.048) in women and limited to low-density lipoprotein (OR =11.829, P=0.023) in men. Women performed worse on the naming score for MoCA than men (P<0.01). Stepwise linear regression analysis showed that education (t=3.689, P<0.001) and smoking (t=2.031, P=0.045) were related to the score of naming in female, while high-density lipoprotein (t=–2.077, P=0.041) was related to the score of naming in male; however, no correlation was found between body mass index and cognitive function in both male and female (P>0.05). Conclusion: Our finding suggests that there are significant sex differences in obesity and specific cognitive domains in aging Chinese Han population with normal cognitive function. Keywords: sex difference, obesity, cognitive function, lipids, elderly Chinese
format	article
author	Li W Qiu Q Sun L Yue L Wang T Li X Xiao S
author_facet	Li W Qiu Q Sun L Yue L Wang T Li X Xiao S
author_sort	Li W
title	Sex differences in obesity and cognitive function in a cognitively normal aging Chinese Han population
title_short	Sex differences in obesity and cognitive function in a cognitively normal aging Chinese Han population
title_full	Sex differences in obesity and cognitive function in a cognitively normal aging Chinese Han population
title_fullStr	Sex differences in obesity and cognitive function in a cognitively normal aging Chinese Han population
title_full_unstemmed	Sex differences in obesity and cognitive function in a cognitively normal aging Chinese Han population
title_sort	sex differences in obesity and cognitive function in a cognitively normal aging chinese han population
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/6448c9c2ca524fd3968dd81c8ff5b062
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_version_	1718399405357268992

Sex differences in obesity and cognitive function in a cognitively normal aging Chinese Han population

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