Biomass Microcapsules with Stem Cell Encapsulation for Bone Repair

Abstract Bone defects caused by trauma, tumor, or osteoarthritis remain challenging due to the lack of effective treatments in clinic. Stem cell transplantation has emerged as an alternative approach for bone repair and attracted widespread attention owing to its excellent biological activities and...

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Autores principales:	Lei Yang, Yuxiao Liu, Lingyu Sun, Cheng Zhao, Guopu Chen, Yuanjin Zhao
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Microcapsule Bone repair Stem cell therapy Microfluidics Electrospray Technology T
Acceso en línea:	https://doaj.org/article/644b591fd8594199acbd4fc4b5b82c57
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spelling	oai:doaj.org-article:644b591fd8594199acbd4fc4b5b82c572021-12-05T12:05:00ZBiomass Microcapsules with Stem Cell Encapsulation for Bone Repair10.1007/s40820-021-00747-82311-67062150-5551https://doaj.org/article/644b591fd8594199acbd4fc4b5b82c572021-12-01T00:00:00Zhttps://doi.org/10.1007/s40820-021-00747-8https://doaj.org/toc/2311-6706https://doaj.org/toc/2150-5551Abstract Bone defects caused by trauma, tumor, or osteoarthritis remain challenging due to the lack of effective treatments in clinic. Stem cell transplantation has emerged as an alternative approach for bone repair and attracted widespread attention owing to its excellent biological activities and therapy effect. The attempts to develop this therapeutic approach focus on the generation of effective cell delivery vehicles, since the shortcomings of direct injection of stem cells into target tissues. Here, we developed a novel core-shell microcapsule with a stem cell-laden core and a biomass shell by using all-aqueous phase microfluidic electrospray technology. The designed core-shell microcapsules showed a high cell viability during the culture procedure. In addition, the animal experiments exhibited that stem cell-laden core-shell microcapsules have good biocompatibility and therapeutic effect for bone defects. This study indicated that the core-shell biomass microcapsules generated by microfluidic electrospray have promising potential in tissue engineering and regenerative medicine.Lei YangYuxiao LiuLingyu SunCheng ZhaoGuopu ChenYuanjin ZhaoSpringerOpenarticleMicrocapsuleBone repairStem cell therapyMicrofluidicsElectrosprayTechnologyTENNano-Micro Letters, Vol 14, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microcapsule Bone repair Stem cell therapy Microfluidics Electrospray Technology T
spellingShingle	Microcapsule Bone repair Stem cell therapy Microfluidics Electrospray Technology T Lei Yang Yuxiao Liu Lingyu Sun Cheng Zhao Guopu Chen Yuanjin Zhao Biomass Microcapsules with Stem Cell Encapsulation for Bone Repair
description	Abstract Bone defects caused by trauma, tumor, or osteoarthritis remain challenging due to the lack of effective treatments in clinic. Stem cell transplantation has emerged as an alternative approach for bone repair and attracted widespread attention owing to its excellent biological activities and therapy effect. The attempts to develop this therapeutic approach focus on the generation of effective cell delivery vehicles, since the shortcomings of direct injection of stem cells into target tissues. Here, we developed a novel core-shell microcapsule with a stem cell-laden core and a biomass shell by using all-aqueous phase microfluidic electrospray technology. The designed core-shell microcapsules showed a high cell viability during the culture procedure. In addition, the animal experiments exhibited that stem cell-laden core-shell microcapsules have good biocompatibility and therapeutic effect for bone defects. This study indicated that the core-shell biomass microcapsules generated by microfluidic electrospray have promising potential in tissue engineering and regenerative medicine.
format	article
author	Lei Yang Yuxiao Liu Lingyu Sun Cheng Zhao Guopu Chen Yuanjin Zhao
author_facet	Lei Yang Yuxiao Liu Lingyu Sun Cheng Zhao Guopu Chen Yuanjin Zhao
author_sort	Lei Yang
title	Biomass Microcapsules with Stem Cell Encapsulation for Bone Repair
title_short	Biomass Microcapsules with Stem Cell Encapsulation for Bone Repair
title_full	Biomass Microcapsules with Stem Cell Encapsulation for Bone Repair
title_fullStr	Biomass Microcapsules with Stem Cell Encapsulation for Bone Repair
title_full_unstemmed	Biomass Microcapsules with Stem Cell Encapsulation for Bone Repair
title_sort	biomass microcapsules with stem cell encapsulation for bone repair
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/644b591fd8594199acbd4fc4b5b82c57
work_keys_str_mv	AT leiyang biomassmicrocapsuleswithstemcellencapsulationforbonerepair AT yuxiaoliu biomassmicrocapsuleswithstemcellencapsulationforbonerepair AT lingyusun biomassmicrocapsuleswithstemcellencapsulationforbonerepair AT chengzhao biomassmicrocapsuleswithstemcellencapsulationforbonerepair AT guopuchen biomassmicrocapsuleswithstemcellencapsulationforbonerepair AT yuanjinzhao biomassmicrocapsuleswithstemcellencapsulationforbonerepair
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Biomass Microcapsules with Stem Cell Encapsulation for Bone Repair

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