Hospital admissions in children with down syndrome: experience of a population-based cohort followed from birth.

<h4>Objective</h4>Children with Down syndrome, the most common genetic cause of intellectual disability, are prone to multiple and varied health-related problems. This study describes patterns of hospitalisations for children and young people with Down syndrome in Western Australia.<h...

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Autores principales:	Patrick Fitzgerald, Helen Leonard, Terri J Pikora, Jenny Bourke, Geoffrey Hammond
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/64506bdd52314136a5bf2fb002fa99b7
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spelling	oai:doaj.org-article:64506bdd52314136a5bf2fb002fa99b72021-11-18T08:59:58ZHospital admissions in children with down syndrome: experience of a population-based cohort followed from birth.1932-620310.1371/journal.pone.0070401https://doaj.org/article/64506bdd52314136a5bf2fb002fa99b72013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23967074/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Children with Down syndrome, the most common genetic cause of intellectual disability, are prone to multiple and varied health-related problems. This study describes patterns of hospitalisations for children and young people with Down syndrome in Western Australia.<h4>Methods</h4>Birth records were linked to the Western Australian population-based Intellectual Disability database to identify all children born with Down syndrome in Western Australia between 1 January, 1983 and 31 December, 1999. These records were linked to the Hospital Morbidity Data System to provide information on all hospitalisations up to 31 December, 2004. Hospitalisation data, coded using ICD-9CM or ICD-10 (v0.5) were grouped into clinically relevant categories using the primary diagnosis. Rates of hospital admission for all and specific diagnoses were expressed in 1000-person-years at-risk and median age at first admission and length of stay were calculated.<h4>Results</h4>Of the 405 children, 395 had one or more hospital admissions, totalling 3786 admissions for all children and an estimated 39.5 person-years in hospital. On average, children were admitted 9.7 times, with an estimated rate of 757.2 admissions per 1000pyr (95% CI: 680, 843). A quarter of all admissions occurred in the first year of life. The average hospital length of stay was 3.8 days (95% CI: 3.7, 4.1). Upper respiratory tract conditions affected the most children (58.5%) and accounted for 12.1% of all admissions. Other disorders which affected a high percentage of children were ear/hearing conditions (50.6%), disorders of the oral cavity (38.0%) and lower respiratory tract conditions (37.5%). Overall, children with Down syndrome were hospitalised at a rate five times (95% CI = 4.3-6.2) that of the general population.<h4>Conclusion</h4>Children with Down syndrome are at increased risk of morbidity for varied causes underlining the importance of comprehensive and targeted primary care for this group.Patrick FitzgeraldHelen LeonardTerri J PikoraJenny BourkeGeoffrey HammondPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e70401 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Patrick Fitzgerald Helen Leonard Terri J Pikora Jenny Bourke Geoffrey Hammond Hospital admissions in children with down syndrome: experience of a population-based cohort followed from birth.
description	<h4>Objective</h4>Children with Down syndrome, the most common genetic cause of intellectual disability, are prone to multiple and varied health-related problems. This study describes patterns of hospitalisations for children and young people with Down syndrome in Western Australia.<h4>Methods</h4>Birth records were linked to the Western Australian population-based Intellectual Disability database to identify all children born with Down syndrome in Western Australia between 1 January, 1983 and 31 December, 1999. These records were linked to the Hospital Morbidity Data System to provide information on all hospitalisations up to 31 December, 2004. Hospitalisation data, coded using ICD-9CM or ICD-10 (v0.5) were grouped into clinically relevant categories using the primary diagnosis. Rates of hospital admission for all and specific diagnoses were expressed in 1000-person-years at-risk and median age at first admission and length of stay were calculated.<h4>Results</h4>Of the 405 children, 395 had one or more hospital admissions, totalling 3786 admissions for all children and an estimated 39.5 person-years in hospital. On average, children were admitted 9.7 times, with an estimated rate of 757.2 admissions per 1000pyr (95% CI: 680, 843). A quarter of all admissions occurred in the first year of life. The average hospital length of stay was 3.8 days (95% CI: 3.7, 4.1). Upper respiratory tract conditions affected the most children (58.5%) and accounted for 12.1% of all admissions. Other disorders which affected a high percentage of children were ear/hearing conditions (50.6%), disorders of the oral cavity (38.0%) and lower respiratory tract conditions (37.5%). Overall, children with Down syndrome were hospitalised at a rate five times (95% CI = 4.3-6.2) that of the general population.<h4>Conclusion</h4>Children with Down syndrome are at increased risk of morbidity for varied causes underlining the importance of comprehensive and targeted primary care for this group.
format	article
author	Patrick Fitzgerald Helen Leonard Terri J Pikora Jenny Bourke Geoffrey Hammond
author_facet	Patrick Fitzgerald Helen Leonard Terri J Pikora Jenny Bourke Geoffrey Hammond
author_sort	Patrick Fitzgerald
title	Hospital admissions in children with down syndrome: experience of a population-based cohort followed from birth.
title_short	Hospital admissions in children with down syndrome: experience of a population-based cohort followed from birth.
title_full	Hospital admissions in children with down syndrome: experience of a population-based cohort followed from birth.
title_fullStr	Hospital admissions in children with down syndrome: experience of a population-based cohort followed from birth.
title_full_unstemmed	Hospital admissions in children with down syndrome: experience of a population-based cohort followed from birth.
title_sort	hospital admissions in children with down syndrome: experience of a population-based cohort followed from birth.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/64506bdd52314136a5bf2fb002fa99b7
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Hospital admissions in children with down syndrome: experience of a population-based cohort followed from birth.

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