Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support

Abstract Background There is limited information about the long-term outcome of patients suffering from acute respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (VV ECMO). Most studies focused on short- to mid-term follow-up. We aimed to investigate l...

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Autores principales:	Jonathan Rilinger, Klara Krötzsch, Xavier Bemtgen, Markus Jäckel, Viviane Zotzmann, Corinna N. Lang, Klaus Kaier, Daniel Duerschmied, Alexander Supady, Christoph Bode, Dawid L. Staudacher, Tobias Wengenmayer
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	ECMO Extracorporeal membrane oxygenation Acute respiratory distress syndrome Outcome Survival Long-term Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
Acceso en línea:	https://doaj.org/article/64508da956f34bdbad371c26167c5a6c
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spelling	oai:doaj.org-article:64508da956f34bdbad371c26167c5a6c2021-12-05T12:03:48ZLong-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support10.1186/s13054-021-03821-01364-8535https://doaj.org/article/64508da956f34bdbad371c26167c5a6c2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13054-021-03821-0https://doaj.org/toc/1364-8535Abstract Background There is limited information about the long-term outcome of patients suffering from acute respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (VV ECMO). Most studies focused on short- to mid-term follow-up. We aimed to investigate long-term survival and health-related quality of life (HRQL) in these patients. Methods We report retrospective data from a single-centre registry of patients with severe ARDS treated with VV ECMO at the Interdisciplinary Medical Intensive Care Unit at the Medical Centre, University of Freiburg, Germany, between 10/2010 and 06/2019. Follow-up data of all patients that survived the index hospitalisation were collected by telephone interviews from 02/2020 till 09/2020. Long-term survival, HRQL (Short-Form Health Survey-36 (SF-36), St. Georges Respiratory Questionnaire (SGRQ), Hospital Anxiety and Depression Scale (HADS)) and the return to work rate were documented. Results In total, 289 patients were treated with VV ECMO during the study period (median age 55 years, 67% males, hospital survival 45%). After a median duration of 3.9 years, follow-up assessment was complete in 94 of 129 hospital survivors (73%). Fifty-three patients completed the HRQL assessment. Hospital survivors showed a high 6- and 12-month survival rate (89% and 85%, respectively). Estimated survival rate of those discharged alive from ICU was 68.5% (95%-CI 56.9–80.1%) after 9.7 years. These patients reported high levels of HRQL (median SF-36 total score 73) and only few pulmonary (median SGRQ total score 19) and mental limitations (median HAD-D score 2 and HAD-A score 3). In total, 80% of the patients were able to resume employment. Conclusion This analysis of VV ECMO patients showed favourable long-term survival and high levels of HRQL suggesting promising prospects for VV ECMO survivors. Graphical AbstractJonathan RilingerKlara KrötzschXavier BemtgenMarkus JäckelViviane ZotzmannCorinna N. LangKlaus KaierDaniel DuerschmiedAlexander SupadyChristoph BodeDawid L. StaudacherTobias WengenmayerBMCarticleECMOExtracorporeal membrane oxygenationAcute respiratory distress syndromeOutcomeSurvivalLong-termMedical emergencies. Critical care. Intensive care. First aidRC86-88.9ENCritical Care, Vol 25, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ECMO Extracorporeal membrane oxygenation Acute respiratory distress syndrome Outcome Survival Long-term Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
spellingShingle	ECMO Extracorporeal membrane oxygenation Acute respiratory distress syndrome Outcome Survival Long-term Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 Jonathan Rilinger Klara Krötzsch Xavier Bemtgen Markus Jäckel Viviane Zotzmann Corinna N. Lang Klaus Kaier Daniel Duerschmied Alexander Supady Christoph Bode Dawid L. Staudacher Tobias Wengenmayer Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support
description	Abstract Background There is limited information about the long-term outcome of patients suffering from acute respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (VV ECMO). Most studies focused on short- to mid-term follow-up. We aimed to investigate long-term survival and health-related quality of life (HRQL) in these patients. Methods We report retrospective data from a single-centre registry of patients with severe ARDS treated with VV ECMO at the Interdisciplinary Medical Intensive Care Unit at the Medical Centre, University of Freiburg, Germany, between 10/2010 and 06/2019. Follow-up data of all patients that survived the index hospitalisation were collected by telephone interviews from 02/2020 till 09/2020. Long-term survival, HRQL (Short-Form Health Survey-36 (SF-36), St. Georges Respiratory Questionnaire (SGRQ), Hospital Anxiety and Depression Scale (HADS)) and the return to work rate were documented. Results In total, 289 patients were treated with VV ECMO during the study period (median age 55 years, 67% males, hospital survival 45%). After a median duration of 3.9 years, follow-up assessment was complete in 94 of 129 hospital survivors (73%). Fifty-three patients completed the HRQL assessment. Hospital survivors showed a high 6- and 12-month survival rate (89% and 85%, respectively). Estimated survival rate of those discharged alive from ICU was 68.5% (95%-CI 56.9–80.1%) after 9.7 years. These patients reported high levels of HRQL (median SF-36 total score 73) and only few pulmonary (median SGRQ total score 19) and mental limitations (median HAD-D score 2 and HAD-A score 3). In total, 80% of the patients were able to resume employment. Conclusion This analysis of VV ECMO patients showed favourable long-term survival and high levels of HRQL suggesting promising prospects for VV ECMO survivors. Graphical Abstract
format	article
author	Jonathan Rilinger Klara Krötzsch Xavier Bemtgen Markus Jäckel Viviane Zotzmann Corinna N. Lang Klaus Kaier Daniel Duerschmied Alexander Supady Christoph Bode Dawid L. Staudacher Tobias Wengenmayer
author_facet	Jonathan Rilinger Klara Krötzsch Xavier Bemtgen Markus Jäckel Viviane Zotzmann Corinna N. Lang Klaus Kaier Daniel Duerschmied Alexander Supady Christoph Bode Dawid L. Staudacher Tobias Wengenmayer
author_sort	Jonathan Rilinger
title	Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support
title_short	Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support
title_full	Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support
title_fullStr	Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support
title_full_unstemmed	Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support
title_sort	long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support
publisher	BMC
publishDate	2021
url	https://doaj.org/article/64508da956f34bdbad371c26167c5a6c
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Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support

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