FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism

Insulin signaling represses Forkhead transcription factor FoxO activity, which contributes to organismal metabolism. Here, the authors use proteomics to identify positively regulated insulin signaling targets FoxK1/K2 and demonstrate their role in lipid metabolism and mitochondrial regulation.

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Autores principales:	Masaji Sakaguchi, Weikang Cai, Chih-Hao Wang, Carly T. Cederquist, Marcos Damasio, Erica P. Homan, Thiago Batista, Alfred K. Ramirez, Manoj K. Gupta, Martin Steger, Nicolai J. Wewer Albrechtsen, Shailendra Kumar Singh, Eiichi Araki, Matthias Mann, Sven Enerbäck, C. Ronald Kahn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6452f44069924205846a1027bdcd7038
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spelling	oai:doaj.org-article:6452f44069924205846a1027bdcd70382021-12-02T15:36:05ZFoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism10.1038/s41467-019-09418-02041-1723https://doaj.org/article/6452f44069924205846a1027bdcd70382019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09418-0https://doaj.org/toc/2041-1723Insulin signaling represses Forkhead transcription factor FoxO activity, which contributes to organismal metabolism. Here, the authors use proteomics to identify positively regulated insulin signaling targets FoxK1/K2 and demonstrate their role in lipid metabolism and mitochondrial regulation.Masaji SakaguchiWeikang CaiChih-Hao WangCarly T. CederquistMarcos DamasioErica P. HomanThiago BatistaAlfred K. RamirezManoj K. GuptaMartin StegerNicolai J. Wewer AlbrechtsenShailendra Kumar SinghEiichi ArakiMatthias MannSven EnerbäckC. Ronald KahnNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Masaji Sakaguchi Weikang Cai Chih-Hao Wang Carly T. Cederquist Marcos Damasio Erica P. Homan Thiago Batista Alfred K. Ramirez Manoj K. Gupta Martin Steger Nicolai J. Wewer Albrechtsen Shailendra Kumar Singh Eiichi Araki Matthias Mann Sven Enerbäck C. Ronald Kahn FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism
description	Insulin signaling represses Forkhead transcription factor FoxO activity, which contributes to organismal metabolism. Here, the authors use proteomics to identify positively regulated insulin signaling targets FoxK1/K2 and demonstrate their role in lipid metabolism and mitochondrial regulation.
format	article
author	Masaji Sakaguchi Weikang Cai Chih-Hao Wang Carly T. Cederquist Marcos Damasio Erica P. Homan Thiago Batista Alfred K. Ramirez Manoj K. Gupta Martin Steger Nicolai J. Wewer Albrechtsen Shailendra Kumar Singh Eiichi Araki Matthias Mann Sven Enerbäck C. Ronald Kahn
author_facet	Masaji Sakaguchi Weikang Cai Chih-Hao Wang Carly T. Cederquist Marcos Damasio Erica P. Homan Thiago Batista Alfred K. Ramirez Manoj K. Gupta Martin Steger Nicolai J. Wewer Albrechtsen Shailendra Kumar Singh Eiichi Araki Matthias Mann Sven Enerbäck C. Ronald Kahn
author_sort	Masaji Sakaguchi
title	FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism
title_short	FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism
title_full	FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism
title_fullStr	FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism
title_full_unstemmed	FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism
title_sort	foxk1 and foxk2 in insulin regulation of cellular and mitochondrial metabolism
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6452f44069924205846a1027bdcd7038
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FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism

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