Radiolabeling, whole-body single photon emission computed tomography/computed tomography imaging, and pharmacokinetics of carbon nanohorns in mice

Minfang Zhang,1,2 Dhifaf A Jasim,1 Cécilia Ménard-Moyon,3 Antonio Nunes,1 Sumio Iijima,2 Alberto Bianco,3 Masako Yudasaka,2 Kostas Kostarelos1 1Nanomedicine Laboratory, Faculty of Medical and Human Sciences and National Graphene Institute, University of Manchester, Ma...

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Autores principales:	Zhang M, Jasim DA, Ménard-Moyon C, Nunes A, Iijima S, Bianco A, Yudasaka M, Kostarelos K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	biodistribution excretion functionalization nanocarbon nanomedicine Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6456d2b04e9043bfb35dc86ae5bb0e77
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spelling	oai:doaj.org-article:6456d2b04e9043bfb35dc86ae5bb0e772021-12-02T00:38:14ZRadiolabeling, whole-body single photon emission computed tomography/computed tomography imaging, and pharmacokinetics of carbon nanohorns in mice1178-2013https://doaj.org/article/6456d2b04e9043bfb35dc86ae5bb0e772016-07-01T00:00:00Zhttps://www.dovepress.com/radiolabeling-whole-body-single-photon-emission-computed-tomographycom-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Minfang Zhang,1,2 Dhifaf A Jasim,1 Cécilia Ménard-Moyon,3 Antonio Nunes,1 Sumio Iijima,2 Alberto Bianco,3 Masako Yudasaka,2 Kostas Kostarelos1 1Nanomedicine Laboratory, Faculty of Medical and Human Sciences and National Graphene Institute, University of Manchester, Manchester, United Kingdom; 2Institute of Advanced Science and Industrial Technology (AIST), Tsukuba, Ibaraki, Japan; 3CNRS, Institute of Molecular and Cellular Biology, Laboratory of Immunopathology and Therapeutic Chemistry, Strasbourg, France Abstract: In this work, we report that the biodistribution and excretion of carbon nanohorns (CNHs) in mice are dependent on their size and functionalization. Small-sized CNHs (30–50 nm; S-CNHs) and large-sized CNHs (80–100 nm; L-CNHs) were chemically functionalized and radiolabeled with [111In]-diethylenetriaminepentaacetic acid and intravenously injected into mice. Their tissue distribution profiles at different time points were determined by single photon emission computed tomography/computed tomography. The results showed that the S-CNHs circulated longer in blood, while the L-CNHs accumulated faster in major organs like the liver and spleen. Small amounts of S-CNHs- and L-CNHs were excreted in urine within the first few hours postinjection, followed by excretion of smaller quantities within the next 48 hours in both urine and feces. The kinetics of excretion for S-CNHs were more rapid than for L-CNHs. Both S-CNH and L-CNH material accumulated mainly in the liver and spleen; however, S-CNH accumulation in the spleen was more prominent than in the liver. Keywords: biodistribution, excretion, functionalization, nano-carbon, nanomedicineZhang MJasim DAMénard-Moyon CNunes AIijima SBianco AYudasaka MKostarelos KDove Medical PressarticlebiodistributionexcretionfunctionalizationnanocarbonnanomedicineMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 3317-3330 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	biodistribution excretion functionalization nanocarbon nanomedicine Medicine (General) R5-920
spellingShingle	biodistribution excretion functionalization nanocarbon nanomedicine Medicine (General) R5-920 Zhang M Jasim DA Ménard-Moyon C Nunes A Iijima S Bianco A Yudasaka M Kostarelos K Radiolabeling, whole-body single photon emission computed tomography/computed tomography imaging, and pharmacokinetics of carbon nanohorns in mice
description	Minfang Zhang,1,2 Dhifaf A Jasim,1 Cécilia Ménard-Moyon,3 Antonio Nunes,1 Sumio Iijima,2 Alberto Bianco,3 Masako Yudasaka,2 Kostas Kostarelos1 1Nanomedicine Laboratory, Faculty of Medical and Human Sciences and National Graphene Institute, University of Manchester, Manchester, United Kingdom; 2Institute of Advanced Science and Industrial Technology (AIST), Tsukuba, Ibaraki, Japan; 3CNRS, Institute of Molecular and Cellular Biology, Laboratory of Immunopathology and Therapeutic Chemistry, Strasbourg, France Abstract: In this work, we report that the biodistribution and excretion of carbon nanohorns (CNHs) in mice are dependent on their size and functionalization. Small-sized CNHs (30–50 nm; S-CNHs) and large-sized CNHs (80–100 nm; L-CNHs) were chemically functionalized and radiolabeled with [111In]-diethylenetriaminepentaacetic acid and intravenously injected into mice. Their tissue distribution profiles at different time points were determined by single photon emission computed tomography/computed tomography. The results showed that the S-CNHs circulated longer in blood, while the L-CNHs accumulated faster in major organs like the liver and spleen. Small amounts of S-CNHs- and L-CNHs were excreted in urine within the first few hours postinjection, followed by excretion of smaller quantities within the next 48 hours in both urine and feces. The kinetics of excretion for S-CNHs were more rapid than for L-CNHs. Both S-CNH and L-CNH material accumulated mainly in the liver and spleen; however, S-CNH accumulation in the spleen was more prominent than in the liver. Keywords: biodistribution, excretion, functionalization, nano-carbon, nanomedicine
format	article
author	Zhang M Jasim DA Ménard-Moyon C Nunes A Iijima S Bianco A Yudasaka M Kostarelos K
author_facet	Zhang M Jasim DA Ménard-Moyon C Nunes A Iijima S Bianco A Yudasaka M Kostarelos K
author_sort	Zhang M
title	Radiolabeling, whole-body single photon emission computed tomography/computed tomography imaging, and pharmacokinetics of carbon nanohorns in mice
title_short	Radiolabeling, whole-body single photon emission computed tomography/computed tomography imaging, and pharmacokinetics of carbon nanohorns in mice
title_full	Radiolabeling, whole-body single photon emission computed tomography/computed tomography imaging, and pharmacokinetics of carbon nanohorns in mice
title_fullStr	Radiolabeling, whole-body single photon emission computed tomography/computed tomography imaging, and pharmacokinetics of carbon nanohorns in mice
title_full_unstemmed	Radiolabeling, whole-body single photon emission computed tomography/computed tomography imaging, and pharmacokinetics of carbon nanohorns in mice
title_sort	radiolabeling, whole-body single photon emission computed tomography/computed tomography imaging, and pharmacokinetics of carbon nanohorns in mice
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/6456d2b04e9043bfb35dc86ae5bb0e77
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Radiolabeling, whole-body single photon emission computed tomography/computed tomography imaging, and pharmacokinetics of carbon nanohorns in mice

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