Evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients.

<h4>Background</h4>Recently, chemical blood parameters gain more attraction as potential prognostic parameters in pancreatic cancer (PC). In the present study we investigated the prognostic relevance of the uric acid (UA) level in blood plasma at the time of diagnosis for overall surviva...

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Autores principales:	Michael Stotz, Joanna Szkandera, Julia Seidel, Tatjana Stojakovic, Hellmut Samonigg, Daniel Reitz, Thomas Gary, Peter Kornprat, Renate Schaberl-Moser, Gerald Hoefler, Armin Gerger, Martin Pichler
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6457536c45e24f80a57db6e5d43e03d3
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spelling	oai:doaj.org-article:6457536c45e24f80a57db6e5d43e03d32021-11-25T06:04:22ZEvaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients.1932-620310.1371/journal.pone.0104730https://doaj.org/article/6457536c45e24f80a57db6e5d43e03d32014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25133546/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Recently, chemical blood parameters gain more attraction as potential prognostic parameters in pancreatic cancer (PC). In the present study we investigated the prognostic relevance of the uric acid (UA) level in blood plasma at the time of diagnosis for overall survival (OS) in a large cohort of patients with PC.<h4>Patients and methods</h4>Data from 466 consecutive patients with ductal adenocarcinoma of the pancreas were evaluated retrospectively. Overall survival (OS) was analysed using the Kaplan-Meier method. To further evaluate the prognostic significance of the UA level, univariate and multivariate Cox regression models were calculated.<h4>Results</h4>None of the clinicopathological parameters (tumour grade, clinical stage, age, CA19-9 level, Karnofski Index (KI) or surgical resection) except gender was associated with UA level. In univariate analysis we observed the elevated UA level (<5.1 versus ≥5.1 mg/dl, p = 0.017) as poor prognostic factor for OS. In the multivariate analysis that included age, gender, tumour grade, tumour stage, surgical resection, CA19-9 level, the KI and UA level we confirmed the UA level as independent prognostic factor for OS (HR = 1.373%; CI = 1.077-1.751; p = 0.011).<h4>Conclusion</h4>In conclusion, we identified the UA level at time of diagnosis as an independent prognostic factor in PC patients. Our results indicate that the UA level might represent a novel and useful marker for patient stratification in PC management.Michael StotzJoanna SzkanderaJulia SeidelTatjana StojakovicHellmut SamoniggDaniel ReitzThomas GaryPeter KornpratRenate Schaberl-MoserGerald HoeflerArmin GergerMartin PichlerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e104730 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael Stotz Joanna Szkandera Julia Seidel Tatjana Stojakovic Hellmut Samonigg Daniel Reitz Thomas Gary Peter Kornprat Renate Schaberl-Moser Gerald Hoefler Armin Gerger Martin Pichler Evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients.
description	<h4>Background</h4>Recently, chemical blood parameters gain more attraction as potential prognostic parameters in pancreatic cancer (PC). In the present study we investigated the prognostic relevance of the uric acid (UA) level in blood plasma at the time of diagnosis for overall survival (OS) in a large cohort of patients with PC.<h4>Patients and methods</h4>Data from 466 consecutive patients with ductal adenocarcinoma of the pancreas were evaluated retrospectively. Overall survival (OS) was analysed using the Kaplan-Meier method. To further evaluate the prognostic significance of the UA level, univariate and multivariate Cox regression models were calculated.<h4>Results</h4>None of the clinicopathological parameters (tumour grade, clinical stage, age, CA19-9 level, Karnofski Index (KI) or surgical resection) except gender was associated with UA level. In univariate analysis we observed the elevated UA level (<5.1 versus ≥5.1 mg/dl, p = 0.017) as poor prognostic factor for OS. In the multivariate analysis that included age, gender, tumour grade, tumour stage, surgical resection, CA19-9 level, the KI and UA level we confirmed the UA level as independent prognostic factor for OS (HR = 1.373%; CI = 1.077-1.751; p = 0.011).<h4>Conclusion</h4>In conclusion, we identified the UA level at time of diagnosis as an independent prognostic factor in PC patients. Our results indicate that the UA level might represent a novel and useful marker for patient stratification in PC management.
format	article
author	Michael Stotz Joanna Szkandera Julia Seidel Tatjana Stojakovic Hellmut Samonigg Daniel Reitz Thomas Gary Peter Kornprat Renate Schaberl-Moser Gerald Hoefler Armin Gerger Martin Pichler
author_facet	Michael Stotz Joanna Szkandera Julia Seidel Tatjana Stojakovic Hellmut Samonigg Daniel Reitz Thomas Gary Peter Kornprat Renate Schaberl-Moser Gerald Hoefler Armin Gerger Martin Pichler
author_sort	Michael Stotz
title	Evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients.
title_short	Evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients.
title_full	Evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients.
title_fullStr	Evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients.
title_full_unstemmed	Evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients.
title_sort	evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/6457536c45e24f80a57db6e5d43e03d3
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Evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients.

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