Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma

Abstract The aim of the present study was to examine the conditions, characteristics, and risk factors of level IIb lymph node metastases in oral squamous cell carcinoma and to formulate surgical criteria for level IIb lymph node dissection. We analyzed clinical and pathological records for 541 oral...

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Autores principales:	Hyunwoo Yang, Nak-Hoon Son, Sung Hwa Lee, Dongwook Kim, Hyung Jun Kim, In-ho Cha, Woong Nam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6459384324f24ed9a6d6596f93beae85
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spelling	oai:doaj.org-article:6459384324f24ed9a6d6596f93beae852021-12-02T19:09:31ZPredictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma10.1038/s41598-021-96827-12045-2322https://doaj.org/article/6459384324f24ed9a6d6596f93beae852021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96827-1https://doaj.org/toc/2045-2322Abstract The aim of the present study was to examine the conditions, characteristics, and risk factors of level IIb lymph node metastases in oral squamous cell carcinoma and to formulate surgical criteria for level IIb lymph node dissection. We analyzed clinical and pathological records for 541 oral squamous carcinoma patients in relation to level IIb metastasis. Univariate and multivariate analyses were performed to detect risk factors for level IIb lymph node metastasis; a predictive model was built based on multivariate analysis and tested in a validation group. Univariate and multivariate analyses using the training group indicated that level IIa metastasis and Lymphovascular permeation (LVP) were two independent risk factors for level IIb lymph node metastasis. This model was built and tested in a validation group, the area under the curve being 0.697 (P < .0.001). The model’s sensitivity was 66.7% and specificity was 77.4%. Nomogram incorporating validated variables was developed for level IIb metastasis prediction. Expected survival probabilites were analysed to specify significance of model's variable on patients’ overall survival and recurrence. Level IIb dissection should be performed in patients with level IIa metastasis and LVP. However, thorough consideration of the oncologic safety of omitting level IIb dissection is compulsory.Hyunwoo YangNak-Hoon SonSung Hwa LeeDongwook KimHyung Jun KimIn-ho ChaWoong NamNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyunwoo Yang Nak-Hoon Son Sung Hwa Lee Dongwook Kim Hyung Jun Kim In-ho Cha Woong Nam Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma
description	Abstract The aim of the present study was to examine the conditions, characteristics, and risk factors of level IIb lymph node metastases in oral squamous cell carcinoma and to formulate surgical criteria for level IIb lymph node dissection. We analyzed clinical and pathological records for 541 oral squamous carcinoma patients in relation to level IIb metastasis. Univariate and multivariate analyses were performed to detect risk factors for level IIb lymph node metastasis; a predictive model was built based on multivariate analysis and tested in a validation group. Univariate and multivariate analyses using the training group indicated that level IIa metastasis and Lymphovascular permeation (LVP) were two independent risk factors for level IIb lymph node metastasis. This model was built and tested in a validation group, the area under the curve being 0.697 (P < .0.001). The model’s sensitivity was 66.7% and specificity was 77.4%. Nomogram incorporating validated variables was developed for level IIb metastasis prediction. Expected survival probabilites were analysed to specify significance of model's variable on patients’ overall survival and recurrence. Level IIb dissection should be performed in patients with level IIa metastasis and LVP. However, thorough consideration of the oncologic safety of omitting level IIb dissection is compulsory.
format	article
author	Hyunwoo Yang Nak-Hoon Son Sung Hwa Lee Dongwook Kim Hyung Jun Kim In-ho Cha Woong Nam
author_facet	Hyunwoo Yang Nak-Hoon Son Sung Hwa Lee Dongwook Kim Hyung Jun Kim In-ho Cha Woong Nam
author_sort	Hyunwoo Yang
title	Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma
title_short	Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma
title_full	Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma
title_fullStr	Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma
title_full_unstemmed	Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma
title_sort	predictive modelling of level iib lymph node metastasis in oral squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6459384324f24ed9a6d6596f93beae85
work_keys_str_mv	AT hyunwooyang predictivemodellingofleveliiblymphnodemetastasisinoralsquamouscellcarcinoma AT nakhoonson predictivemodellingofleveliiblymphnodemetastasisinoralsquamouscellcarcinoma AT sunghwalee predictivemodellingofleveliiblymphnodemetastasisinoralsquamouscellcarcinoma AT dongwookkim predictivemodellingofleveliiblymphnodemetastasisinoralsquamouscellcarcinoma AT hyungjunkim predictivemodellingofleveliiblymphnodemetastasisinoralsquamouscellcarcinoma AT inhocha predictivemodellingofleveliiblymphnodemetastasisinoralsquamouscellcarcinoma AT woongnam predictivemodellingofleveliiblymphnodemetastasisinoralsquamouscellcarcinoma
_version_	1718377090531721216

Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma

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