Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

SOX2 is required for the maintenance of glioblastoma stem cells (GSCs). Here the authors identify that the RING family E3 ubiquitin ligase TRIM26 promotes SOX2 stability in a non-canonical ligase-independent manner and thus, increases the tumorigenicity of GSCs.

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Autores principales:	Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/645b94fb0bcb4d7ebd478a5671649a21
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spelling	oai:doaj.org-article:645b94fb0bcb4d7ebd478a5671649a212021-11-08T11:12:14ZCompetitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma10.1038/s41467-021-26653-62041-1723https://doaj.org/article/645b94fb0bcb4d7ebd478a5671649a212021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26653-6https://doaj.org/toc/2041-1723SOX2 is required for the maintenance of glioblastoma stem cells (GSCs). Here the authors identify that the RING family E3 ubiquitin ligase TRIM26 promotes SOX2 stability in a non-canonical ligase-independent manner and thus, increases the tumorigenicity of GSCs.Tatenda MahlokozeraBhuvic PatelHao ChenPatrick DesouzaXuan QuDiane D. MaoDaniel HafezWei YangRukayat TaiwoMounica PaturuAfshin SalehiAmit D. GujarGavin P. DunnNima MosammaparastAllegra A. PettiHiroko YanoAlbert H. KimNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tatenda Mahlokozera Bhuvic Patel Hao Chen Patrick Desouza Xuan Qu Diane D. Mao Daniel Hafez Wei Yang Rukayat Taiwo Mounica Paturu Afshin Salehi Amit D. Gujar Gavin P. Dunn Nima Mosammaparast Allegra A. Petti Hiroko Yano Albert H. Kim Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
description	SOX2 is required for the maintenance of glioblastoma stem cells (GSCs). Here the authors identify that the RING family E3 ubiquitin ligase TRIM26 promotes SOX2 stability in a non-canonical ligase-independent manner and thus, increases the tumorigenicity of GSCs.
format	article
author	Tatenda Mahlokozera Bhuvic Patel Hao Chen Patrick Desouza Xuan Qu Diane D. Mao Daniel Hafez Wei Yang Rukayat Taiwo Mounica Paturu Afshin Salehi Amit D. Gujar Gavin P. Dunn Nima Mosammaparast Allegra A. Petti Hiroko Yano Albert H. Kim
author_facet	Tatenda Mahlokozera Bhuvic Patel Hao Chen Patrick Desouza Xuan Qu Diane D. Mao Daniel Hafez Wei Yang Rukayat Taiwo Mounica Paturu Afshin Salehi Amit D. Gujar Gavin P. Dunn Nima Mosammaparast Allegra A. Petti Hiroko Yano Albert H. Kim
author_sort	Tatenda Mahlokozera
title	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
title_short	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
title_full	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
title_fullStr	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
title_full_unstemmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
title_sort	competitive binding of e3 ligases trim26 and wwp2 controls sox2 in glioblastoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/645b94fb0bcb4d7ebd478a5671649a21
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Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

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