Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring

Summary: Fetal growth restriction (FGR) increases the risk for impaired cognitive function later in life. However, the precise mechanisms remain elusive. Using dexamethasone-induced FGR and protein restriction-influenced FGR mouse models, we observe learning and memory deficits in adult FGR offsprin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wen Chen, Nana Liu, Shijun Shen, Wei Zhu, Jing Qiao, Shujuan Chang, Jianfeng Dong, Mingliang Bai, Li Ma, Shanshan Wang, Wenwen Jia, Xudong Guo, Ang Li, Jiajie Xi, Cizhong Jiang, Jiuhong Kang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	fetal growth restriction cognition hippocampal neurogenesis neural stem cells Tet1 Notch signaling Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/645d4d330e0149018222cc3e230c4f2e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:645d4d330e0149018222cc3e230c4f2e
record_format	dspace
spelling	oai:doaj.org-article:645d4d330e0149018222cc3e230c4f2e2021-11-04T04:28:57ZFetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring2211-124710.1016/j.celrep.2021.109912https://doaj.org/article/645d4d330e0149018222cc3e230c4f2e2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211124721013851https://doaj.org/toc/2211-1247Summary: Fetal growth restriction (FGR) increases the risk for impaired cognitive function later in life. However, the precise mechanisms remain elusive. Using dexamethasone-induced FGR and protein restriction-influenced FGR mouse models, we observe learning and memory deficits in adult FGR offspring. FGR induces decreased hippocampal neurogenesis from the early post-natal period to adulthood by reducing the proliferation of neural stem cells (NSCs). We further find a persistent decrease of Tet1 expression in hippocampal NSCs of FGR mice. Mechanistically, Tet1 downregulation results in hypermethylation of the Dll3 and Notch1 promoters and inhibition of Notch signaling, leading to reduced NSC proliferation. Overexpression of Tet1 activates Notch signaling, offsets the decline in neurogenesis, and enhances learning and memory abilities in FGR offspring. Our data indicate that a long-term decrease in Tet1/Notch signaling in hippocampal NSCs contributes to impaired neurogenesis following FGR and could serve as potential targets for the intervention of FGR-related cognitive disorders.Wen ChenNana LiuShijun ShenWei ZhuJing QiaoShujuan ChangJianfeng DongMingliang BaiLi MaShanshan WangWenwen JiaXudong GuoAng LiJiajie XiCizhong JiangJiuhong KangElsevierarticlefetal growth restrictioncognitionhippocampal neurogenesisneural stem cellsTet1Notch signalingBiology (General)QH301-705.5ENCell Reports, Vol 37, Iss 5, Pp 109912- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fetal growth restriction cognition hippocampal neurogenesis neural stem cells Tet1 Notch signaling Biology (General) QH301-705.5
spellingShingle	fetal growth restriction cognition hippocampal neurogenesis neural stem cells Tet1 Notch signaling Biology (General) QH301-705.5 Wen Chen Nana Liu Shijun Shen Wei Zhu Jing Qiao Shujuan Chang Jianfeng Dong Mingliang Bai Li Ma Shanshan Wang Wenwen Jia Xudong Guo Ang Li Jiajie Xi Cizhong Jiang Jiuhong Kang Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring
description	Summary: Fetal growth restriction (FGR) increases the risk for impaired cognitive function later in life. However, the precise mechanisms remain elusive. Using dexamethasone-induced FGR and protein restriction-influenced FGR mouse models, we observe learning and memory deficits in adult FGR offspring. FGR induces decreased hippocampal neurogenesis from the early post-natal period to adulthood by reducing the proliferation of neural stem cells (NSCs). We further find a persistent decrease of Tet1 expression in hippocampal NSCs of FGR mice. Mechanistically, Tet1 downregulation results in hypermethylation of the Dll3 and Notch1 promoters and inhibition of Notch signaling, leading to reduced NSC proliferation. Overexpression of Tet1 activates Notch signaling, offsets the decline in neurogenesis, and enhances learning and memory abilities in FGR offspring. Our data indicate that a long-term decrease in Tet1/Notch signaling in hippocampal NSCs contributes to impaired neurogenesis following FGR and could serve as potential targets for the intervention of FGR-related cognitive disorders.
format	article
author	Wen Chen Nana Liu Shijun Shen Wei Zhu Jing Qiao Shujuan Chang Jianfeng Dong Mingliang Bai Li Ma Shanshan Wang Wenwen Jia Xudong Guo Ang Li Jiajie Xi Cizhong Jiang Jiuhong Kang
author_facet	Wen Chen Nana Liu Shijun Shen Wei Zhu Jing Qiao Shujuan Chang Jianfeng Dong Mingliang Bai Li Ma Shanshan Wang Wenwen Jia Xudong Guo Ang Li Jiajie Xi Cizhong Jiang Jiuhong Kang
author_sort	Wen Chen
title	Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring
title_short	Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring
title_full	Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring
title_fullStr	Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring
title_full_unstemmed	Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring
title_sort	fetal growth restriction impairs hippocampal neurogenesis and cognition via tet1 in offspring
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/645d4d330e0149018222cc3e230c4f2e
work_keys_str_mv	AT wenchen fetalgrowthrestrictionimpairshippocampalneurogenesisandcognitionviatet1inoffspring AT nanaliu fetalgrowthrestrictionimpairshippocampalneurogenesisandcognitionviatet1inoffspring AT shijunshen fetalgrowthrestrictionimpairshippocampalneurogenesisandcognitionviatet1inoffspring AT weizhu fetalgrowthrestrictionimpairshippocampalneurogenesisandcognitionviatet1inoffspring AT jingqiao fetalgrowthrestrictionimpairshippocampalneurogenesisandcognitionviatet1inoffspring AT shujuanchang fetalgrowthrestrictionimpairshippocampalneurogenesisandcognitionviatet1inoffspring AT jianfengdong fetalgrowthrestrictionimpairshippocampalneurogenesisandcognitionviatet1inoffspring AT mingliangbai fetalgrowthrestrictionimpairshippocampalneurogenesisandcognitionviatet1inoffspring AT lima fetalgrowthrestrictionimpairshippocampalneurogenesisandcognitionviatet1inoffspring AT shanshanwang fetalgrowthrestrictionimpairshippocampalneurogenesisandcognitionviatet1inoffspring AT wenwenjia fetalgrowthrestrictionimpairshippocampalneurogenesisandcognitionviatet1inoffspring AT xudongguo fetalgrowthrestrictionimpairshippocampalneurogenesisandcognitionviatet1inoffspring AT angli fetalgrowthrestrictionimpairshippocampalneurogenesisandcognitionviatet1inoffspring AT jiajiexi fetalgrowthrestrictionimpairshippocampalneurogenesisandcognitionviatet1inoffspring AT cizhongjiang fetalgrowthrestrictionimpairshippocampalneurogenesisandcognitionviatet1inoffspring AT jiuhongkang fetalgrowthrestrictionimpairshippocampalneurogenesisandcognitionviatet1inoffspring
_version_	1718445275842871296

Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring

Ejemplares similares