Lung Deposition of Surfactant Delivered via a Dedicated Laryngeal Mask Airway in Piglets

It is unknown if the lung deposition of surfactant administered via a catheter placed through a laryngeal mask airway (LMA) is equivalent to that obtained by bolus instillation through an endotracheal tube. We compare the lung deposition of surfactant delivered via two types of LMA with the standard...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anders Nord, Doris Cunha-Goncalves, Rikard Linnér, Federico Bianco, Fabrizio Salomone, Francesca Ricci, Marta Lombardini, Massimo Micaglio, Daniele Trevisanuto, Valeria Perez-de-Sa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	surfactant lung deposition laryngeal mask airway newborn scintigraphy Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/645dbdabab2e41f190b62eb4c1e0d7ae
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:645dbdabab2e41f190b62eb4c1e0d7ae
record_format	dspace
spelling	oai:doaj.org-article:645dbdabab2e41f190b62eb4c1e0d7ae2021-11-25T18:41:13ZLung Deposition of Surfactant Delivered via a Dedicated Laryngeal Mask Airway in Piglets10.3390/pharmaceutics131118581999-4923https://doaj.org/article/645dbdabab2e41f190b62eb4c1e0d7ae2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1858https://doaj.org/toc/1999-4923It is unknown if the lung deposition of surfactant administered via a catheter placed through a laryngeal mask airway (LMA) is equivalent to that obtained by bolus instillation through an endotracheal tube. We compare the lung deposition of surfactant delivered via two types of LMA with the standard technique of endotracheal instillation. 25 newborn piglets on continuous positive airway pressure support (CPAP) were randomized into three groups: 1—LMA-camera (integrated camera and catheter channel; catheter tip below vocal cords), 2—LMA-standard (no camera, no channel; catheter tip above the glottis), 3—InSurE (Intubation, Surfactant administration, Extubation; catheter tip below end of endotracheal tube). All animals received 100 mg·kg<sup>−1</sup> of poractant alfa mixed with <sup>99m</sup>Technetium-nanocolloid. Surfactant deposition was measured by gamma scintigraphy as a percentage of the administered dose. The median (range) total lung surfactant deposition was 68% (10–85), 41% (5–88), and 88% (67–92) in LMA-camera, LMA-standard, and InSurE, respectively, which was higher (<i>p</i> < 0.05) in the latter. The deposition in the stomach and nasopharynx was higher with the LMA-standard. The surfactant deposition via an LMA was lower than that obtained with InSurE. Although not statistically significant, introducing the catheter below the vocal cords under visual control with an integrated camera improved surfactant LMA delivery by 65%.Anders NordDoris Cunha-GoncalvesRikard LinnérFederico BiancoFabrizio SalomoneFrancesca RicciMarta LombardiniMassimo MicaglioDaniele TrevisanutoValeria Perez-de-SaMDPI AGarticlesurfactantlung depositionlaryngeal mask airwaynewbornscintigraphyPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1858, p 1858 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	surfactant lung deposition laryngeal mask airway newborn scintigraphy Pharmacy and materia medica RS1-441
spellingShingle	surfactant lung deposition laryngeal mask airway newborn scintigraphy Pharmacy and materia medica RS1-441 Anders Nord Doris Cunha-Goncalves Rikard Linnér Federico Bianco Fabrizio Salomone Francesca Ricci Marta Lombardini Massimo Micaglio Daniele Trevisanuto Valeria Perez-de-Sa Lung Deposition of Surfactant Delivered via a Dedicated Laryngeal Mask Airway in Piglets
description	It is unknown if the lung deposition of surfactant administered via a catheter placed through a laryngeal mask airway (LMA) is equivalent to that obtained by bolus instillation through an endotracheal tube. We compare the lung deposition of surfactant delivered via two types of LMA with the standard technique of endotracheal instillation. 25 newborn piglets on continuous positive airway pressure support (CPAP) were randomized into three groups: 1—LMA-camera (integrated camera and catheter channel; catheter tip below vocal cords), 2—LMA-standard (no camera, no channel; catheter tip above the glottis), 3—InSurE (Intubation, Surfactant administration, Extubation; catheter tip below end of endotracheal tube). All animals received 100 mg·kg<sup>−1</sup> of poractant alfa mixed with <sup>99m</sup>Technetium-nanocolloid. Surfactant deposition was measured by gamma scintigraphy as a percentage of the administered dose. The median (range) total lung surfactant deposition was 68% (10–85), 41% (5–88), and 88% (67–92) in LMA-camera, LMA-standard, and InSurE, respectively, which was higher (<i>p</i> < 0.05) in the latter. The deposition in the stomach and nasopharynx was higher with the LMA-standard. The surfactant deposition via an LMA was lower than that obtained with InSurE. Although not statistically significant, introducing the catheter below the vocal cords under visual control with an integrated camera improved surfactant LMA delivery by 65%.
format	article
author	Anders Nord Doris Cunha-Goncalves Rikard Linnér Federico Bianco Fabrizio Salomone Francesca Ricci Marta Lombardini Massimo Micaglio Daniele Trevisanuto Valeria Perez-de-Sa
author_facet	Anders Nord Doris Cunha-Goncalves Rikard Linnér Federico Bianco Fabrizio Salomone Francesca Ricci Marta Lombardini Massimo Micaglio Daniele Trevisanuto Valeria Perez-de-Sa
author_sort	Anders Nord
title	Lung Deposition of Surfactant Delivered via a Dedicated Laryngeal Mask Airway in Piglets
title_short	Lung Deposition of Surfactant Delivered via a Dedicated Laryngeal Mask Airway in Piglets
title_full	Lung Deposition of Surfactant Delivered via a Dedicated Laryngeal Mask Airway in Piglets
title_fullStr	Lung Deposition of Surfactant Delivered via a Dedicated Laryngeal Mask Airway in Piglets
title_full_unstemmed	Lung Deposition of Surfactant Delivered via a Dedicated Laryngeal Mask Airway in Piglets
title_sort	lung deposition of surfactant delivered via a dedicated laryngeal mask airway in piglets
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/645dbdabab2e41f190b62eb4c1e0d7ae
work_keys_str_mv	AT andersnord lungdepositionofsurfactantdeliveredviaadedicatedlaryngealmaskairwayinpiglets AT doriscunhagoncalves lungdepositionofsurfactantdeliveredviaadedicatedlaryngealmaskairwayinpiglets AT rikardlinner lungdepositionofsurfactantdeliveredviaadedicatedlaryngealmaskairwayinpiglets AT federicobianco lungdepositionofsurfactantdeliveredviaadedicatedlaryngealmaskairwayinpiglets AT fabriziosalomone lungdepositionofsurfactantdeliveredviaadedicatedlaryngealmaskairwayinpiglets AT francescaricci lungdepositionofsurfactantdeliveredviaadedicatedlaryngealmaskairwayinpiglets AT martalombardini lungdepositionofsurfactantdeliveredviaadedicatedlaryngealmaskairwayinpiglets AT massimomicaglio lungdepositionofsurfactantdeliveredviaadedicatedlaryngealmaskairwayinpiglets AT danieletrevisanuto lungdepositionofsurfactantdeliveredviaadedicatedlaryngealmaskairwayinpiglets AT valeriaperezdesa lungdepositionofsurfactantdeliveredviaadedicatedlaryngealmaskairwayinpiglets
_version_	1718410774822518784

Lung Deposition of Surfactant Delivered via a Dedicated Laryngeal Mask Airway in Piglets

Ejemplares similares