Progressive divisions of multipotent neural progenitors generate late-born chandelier cells in the neocortex

Diverse GABAergic neurons arise from progenitors in the medial ganglionic eminence. Here, the authors show these progenitors are progressively fate-restricted, with early-born interneurons occupying cortex in an “inside-out” pattern and later-born types like chandelier cells generated “outside-in”....

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Auteurs principaux: Khadeejah T. Sultan, Wenying Angela Liu, Zhao-Lu Li, Zhongfu Shen, Zhizhong Li, Xin-Jun Zhang, Owen Dean, Jian Ma, Song-Hai Shi
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Accès en ligne:https://doaj.org/article/645dd5daf8f3460f82baaabe5d2ce9ec
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Résumé:Diverse GABAergic neurons arise from progenitors in the medial ganglionic eminence. Here, the authors show these progenitors are progressively fate-restricted, with early-born interneurons occupying cortex in an “inside-out” pattern and later-born types like chandelier cells generated “outside-in”.