IMMUNOLOGICAL ASPECTS OF ESSENTIAL HYPERTENSION

According to modern concept of the etiopathogenesis of essential hypertension, immune cells play an important role in its development. Mediators produced by immunocompetent cells participate in the initiation and maintenance of chronic systemic inflammation and promote the development of vascular re...

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Autor principal:	Ya. R. Timasheva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	essential hypertension blood pressure inflammation cytokines chemokines t cells Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/645e681eb1254da08ed9375195ef2a85
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spelling	oai:doaj.org-article:645e681eb1254da08ed9375195ef2a852021-11-18T08:03:48ZIMMUNOLOGICAL ASPECTS OF ESSENTIAL HYPERTENSION1563-06252313-741X10.15789/1563-0625-2019-3-407-418https://doaj.org/article/645e681eb1254da08ed9375195ef2a852019-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1814https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAccording to modern concept of the etiopathogenesis of essential hypertension, immune cells play an important role in its development. Mediators produced by immunocompetent cells participate in the initiation and maintenance of chronic systemic inflammation and promote the development of vascular remodeling which is an important part of the pathogenesis of the disease and target organ damage. The immune mechanisms underlying blood pressure elevation include the activation of innate and adaptive immune cells. Endothelial damage triggers an inflammatory cascade, causing migration of the immune cells to the inflammatory site, mediated by chemokines and adhesion molecules. Macrophage infiltration of perivascular tissue contributes to impaired vasodilation and damage to target organs due to the production of active forms of oxygen. Angiotensin II also causes T cell infiltration of perivascular adipose tissue and adventitia and an increased production of tumor necrosis factor alpha and interferon gamma. In addition, T lymphocytes express the mineralocorticoid receptor involved in the development of systemic hypertension. An important role in the progression of hypertension belongs to interleukin-17, which is involved in blood pressure elevation and vascular remodeling. The review also contains data on the effect of gut microbiota on the regulation of blood pressure and the development of hypertension.Ya. R. TimashevaSPb RAACIarticleessential hypertensionblood pressureinflammationcytokineschemokinest cellsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 3, Pp 407-418 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	essential hypertension blood pressure inflammation cytokines chemokines t cells Immunologic diseases. Allergy RC581-607
spellingShingle	essential hypertension blood pressure inflammation cytokines chemokines t cells Immunologic diseases. Allergy RC581-607 Ya. R. Timasheva IMMUNOLOGICAL ASPECTS OF ESSENTIAL HYPERTENSION
description	According to modern concept of the etiopathogenesis of essential hypertension, immune cells play an important role in its development. Mediators produced by immunocompetent cells participate in the initiation and maintenance of chronic systemic inflammation and promote the development of vascular remodeling which is an important part of the pathogenesis of the disease and target organ damage. The immune mechanisms underlying blood pressure elevation include the activation of innate and adaptive immune cells. Endothelial damage triggers an inflammatory cascade, causing migration of the immune cells to the inflammatory site, mediated by chemokines and adhesion molecules. Macrophage infiltration of perivascular tissue contributes to impaired vasodilation and damage to target organs due to the production of active forms of oxygen. Angiotensin II also causes T cell infiltration of perivascular adipose tissue and adventitia and an increased production of tumor necrosis factor alpha and interferon gamma. In addition, T lymphocytes express the mineralocorticoid receptor involved in the development of systemic hypertension. An important role in the progression of hypertension belongs to interleukin-17, which is involved in blood pressure elevation and vascular remodeling. The review also contains data on the effect of gut microbiota on the regulation of blood pressure and the development of hypertension.
format	article
author	Ya. R. Timasheva
author_facet	Ya. R. Timasheva
author_sort	Ya. R. Timasheva
title	IMMUNOLOGICAL ASPECTS OF ESSENTIAL HYPERTENSION
title_short	IMMUNOLOGICAL ASPECTS OF ESSENTIAL HYPERTENSION
title_full	IMMUNOLOGICAL ASPECTS OF ESSENTIAL HYPERTENSION
title_fullStr	IMMUNOLOGICAL ASPECTS OF ESSENTIAL HYPERTENSION
title_full_unstemmed	IMMUNOLOGICAL ASPECTS OF ESSENTIAL HYPERTENSION
title_sort	immunological aspects of essential hypertension
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/645e681eb1254da08ed9375195ef2a85
work_keys_str_mv	AT yartimasheva immunologicalaspectsofessentialhypertension
_version_	1718422354157109248

IMMUNOLOGICAL ASPECTS OF ESSENTIAL HYPERTENSION

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