The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2

Obesity is a worldwide problem of the last century, the prevalence of which has reached pandemic proportions in developed countries. Over the past few years, a considerable amount of data has been gathered, reporting a direct link between changes in gut microbiota and the development of obesity, as...

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Autores principales:	Elena V. Pokrovskaya, Minara S. Shamkhalova, Marina V. Shestakova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2019
Materias:	obesity gut microbiota diabetes mellitus type 2 bariatric surgery glucose-lowering probiotics fecal microbiota transplantation Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/6465b11b6f634a90a81c1c22cd7fb1cc
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spelling	oai:doaj.org-article:6465b11b6f634a90a81c1c22cd7fb1cc2021-11-14T09:00:22ZThe new views on the state of the gut microbiota in obesity and diabetes mellitus type 22072-03512072-037810.14341/DM10194https://doaj.org/article/6465b11b6f634a90a81c1c22cd7fb1cc2019-08-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/10194https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Obesity is a worldwide problem of the last century, the prevalence of which has reached pandemic proportions in developed countries. Over the past few years, a considerable amount of data has been gathered, reporting a direct link between changes in gut microbiota and the development of obesity, as well as related diseases, primarily, diabetes mellitus type 2. The elaboration of optimal methods of prevention and treatment regimens of these diseases needs to structure the existing knowledge about the mechanisms of development of metabolic disorders, the role of intestinal microbiota in the latter and possible therapeutic “targets”. This review examines the role of microorganisms in the human body, with the main focus on the developmental origins of metabolic disorders using animal models and accumulated experience of research on their effects on the human body, and also discusses possible treatment options, including bariatric surgery, fecal microbiota transplantation, the use of pre- and probiotics and certain particular groups of glucose-lowering drugs.Elena V. PokrovskayaMinara S. ShamkhalovaMarina V. ShestakovaEndocrinology Research Centrearticleobesitygut microbiotadiabetes mellitus type 2bariatric surgeryglucose-loweringprobioticsfecal microbiota transplantationNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 22, Iss 3, Pp 253-262 (2019)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	obesity gut microbiota diabetes mellitus type 2 bariatric surgery glucose-lowering probiotics fecal microbiota transplantation Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	obesity gut microbiota diabetes mellitus type 2 bariatric surgery glucose-lowering probiotics fecal microbiota transplantation Nutritional diseases. Deficiency diseases RC620-627 Elena V. Pokrovskaya Minara S. Shamkhalova Marina V. Shestakova The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2
description	Obesity is a worldwide problem of the last century, the prevalence of which has reached pandemic proportions in developed countries. Over the past few years, a considerable amount of data has been gathered, reporting a direct link between changes in gut microbiota and the development of obesity, as well as related diseases, primarily, diabetes mellitus type 2. The elaboration of optimal methods of prevention and treatment regimens of these diseases needs to structure the existing knowledge about the mechanisms of development of metabolic disorders, the role of intestinal microbiota in the latter and possible therapeutic “targets”. This review examines the role of microorganisms in the human body, with the main focus on the developmental origins of metabolic disorders using animal models and accumulated experience of research on their effects on the human body, and also discusses possible treatment options, including bariatric surgery, fecal microbiota transplantation, the use of pre- and probiotics and certain particular groups of glucose-lowering drugs.
format	article
author	Elena V. Pokrovskaya Minara S. Shamkhalova Marina V. Shestakova
author_facet	Elena V. Pokrovskaya Minara S. Shamkhalova Marina V. Shestakova
author_sort	Elena V. Pokrovskaya
title	The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2
title_short	The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2
title_full	The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2
title_fullStr	The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2
title_full_unstemmed	The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2
title_sort	new views on the state of the gut microbiota in obesity and diabetes mellitus type 2
publisher	Endocrinology Research Centre
publishDate	2019
url	https://doaj.org/article/6465b11b6f634a90a81c1c22cd7fb1cc
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The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2

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