Inferring multilayer interactome networks shaping phenotypic plasticity and evolution

Genetic plasticity drives phenotypic differences. Here, the authors develop a framework to quantify the individual and combinatorial contributions of SNPs on a phenotype of interest and use it to identify SNP-SNP interactions associated with variations in bacteria’s response to external changes.

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Detalles Bibliográficos
Autores principales: Dengcheng Yang, Yi Jin, Xiaoqing He, Ang Dong, Jing Wang, Rongling Wu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/6469cecdafd94ea58b6bbbc6fab63a44
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Descripción
Sumario:Genetic plasticity drives phenotypic differences. Here, the authors develop a framework to quantify the individual and combinatorial contributions of SNPs on a phenotype of interest and use it to identify SNP-SNP interactions associated with variations in bacteria’s response to external changes.