Mixed Pulmonary Adenocarcinoma and Atypical Carcinoid: A Report of Two Cases of a Non-codified Entity With Biological Profile

Pulmonary carcinoids combined with a non-neuroendocrine component have rarely been described, and this histological subtype is not included as a specific entity in the current World Health Organization classification of pulmonary neoplasms. Here, we described the molecular and histological features...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Paola Parente, Antonio Rossi, Angelo Sparaneo, Federico Pio Fabrizio, Antonella Centonza, Marco Taurchini, Tommaso Mazza, Maurizio Cassano, Giuseppe Miscio, Flavia Centra, Gian Maria Ferretti, Concetta Martina Di Micco, Paolo Graziano, Lucia Anna Muscarella
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	lung atypical carcinoid adenocarcinoma mixed neoplasm monoclonality next-generation sequencing Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/646af9e64ee54bc89df7af38cc484a7b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:646af9e64ee54bc89df7af38cc484a7b
record_format	dspace
spelling	oai:doaj.org-article:646af9e64ee54bc89df7af38cc484a7b2021-12-03T05:40:19ZMixed Pulmonary Adenocarcinoma and Atypical Carcinoid: A Report of Two Cases of a Non-codified Entity With Biological Profile2296-889X10.3389/fmolb.2021.784876https://doaj.org/article/646af9e64ee54bc89df7af38cc484a7b2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.784876/fullhttps://doaj.org/toc/2296-889XPulmonary carcinoids combined with a non-neuroendocrine component have rarely been described, and this histological subtype is not included as a specific entity in the current World Health Organization classification of pulmonary neoplasms. Here, we described the molecular and histological features of two rare cases of mixed lung neoplasms, composed of atypical carcinoid and adenocarcinoma. The targeted next-generation sequencing analysis covering single nucleotide variations, copy number variations, and transcript fusions in a total of 161 cancer genes of the two different tumor components shows a similar molecular profile of shared and private gene mutations. These findings suggest their monoclonal origin from a transformed stem/progenitor tumor cell, which acquires a divergent differentiation during its development and progression and accumulates novel, specific mutations.Paola ParenteAntonio RossiAngelo SparaneoFederico Pio FabrizioAntonella CentonzaMarco TaurchiniTommaso MazzaMaurizio CassanoGiuseppe MiscioFlavia CentraGian Maria FerrettiConcetta Martina Di MiccoPaolo GrazianoLucia Anna MuscarellaFrontiers Media S.A.articlelungatypical carcinoidadenocarcinomamixed neoplasmmonoclonalitynext-generation sequencingBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung atypical carcinoid adenocarcinoma mixed neoplasm monoclonality next-generation sequencing Biology (General) QH301-705.5
spellingShingle	lung atypical carcinoid adenocarcinoma mixed neoplasm monoclonality next-generation sequencing Biology (General) QH301-705.5 Paola Parente Antonio Rossi Angelo Sparaneo Federico Pio Fabrizio Antonella Centonza Marco Taurchini Tommaso Mazza Maurizio Cassano Giuseppe Miscio Flavia Centra Gian Maria Ferretti Concetta Martina Di Micco Paolo Graziano Lucia Anna Muscarella Mixed Pulmonary Adenocarcinoma and Atypical Carcinoid: A Report of Two Cases of a Non-codified Entity With Biological Profile
description	Pulmonary carcinoids combined with a non-neuroendocrine component have rarely been described, and this histological subtype is not included as a specific entity in the current World Health Organization classification of pulmonary neoplasms. Here, we described the molecular and histological features of two rare cases of mixed lung neoplasms, composed of atypical carcinoid and adenocarcinoma. The targeted next-generation sequencing analysis covering single nucleotide variations, copy number variations, and transcript fusions in a total of 161 cancer genes of the two different tumor components shows a similar molecular profile of shared and private gene mutations. These findings suggest their monoclonal origin from a transformed stem/progenitor tumor cell, which acquires a divergent differentiation during its development and progression and accumulates novel, specific mutations.
format	article
author	Paola Parente Antonio Rossi Angelo Sparaneo Federico Pio Fabrizio Antonella Centonza Marco Taurchini Tommaso Mazza Maurizio Cassano Giuseppe Miscio Flavia Centra Gian Maria Ferretti Concetta Martina Di Micco Paolo Graziano Lucia Anna Muscarella
author_facet	Paola Parente Antonio Rossi Angelo Sparaneo Federico Pio Fabrizio Antonella Centonza Marco Taurchini Tommaso Mazza Maurizio Cassano Giuseppe Miscio Flavia Centra Gian Maria Ferretti Concetta Martina Di Micco Paolo Graziano Lucia Anna Muscarella
author_sort	Paola Parente
title	Mixed Pulmonary Adenocarcinoma and Atypical Carcinoid: A Report of Two Cases of a Non-codified Entity With Biological Profile
title_short	Mixed Pulmonary Adenocarcinoma and Atypical Carcinoid: A Report of Two Cases of a Non-codified Entity With Biological Profile
title_full	Mixed Pulmonary Adenocarcinoma and Atypical Carcinoid: A Report of Two Cases of a Non-codified Entity With Biological Profile
title_fullStr	Mixed Pulmonary Adenocarcinoma and Atypical Carcinoid: A Report of Two Cases of a Non-codified Entity With Biological Profile
title_full_unstemmed	Mixed Pulmonary Adenocarcinoma and Atypical Carcinoid: A Report of Two Cases of a Non-codified Entity With Biological Profile
title_sort	mixed pulmonary adenocarcinoma and atypical carcinoid: a report of two cases of a non-codified entity with biological profile
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/646af9e64ee54bc89df7af38cc484a7b
work_keys_str_mv	AT paolaparente mixedpulmonaryadenocarcinomaandatypicalcarcinoidareportoftwocasesofanoncodifiedentitywithbiologicalprofile AT antoniorossi mixedpulmonaryadenocarcinomaandatypicalcarcinoidareportoftwocasesofanoncodifiedentitywithbiologicalprofile AT angelosparaneo mixedpulmonaryadenocarcinomaandatypicalcarcinoidareportoftwocasesofanoncodifiedentitywithbiologicalprofile AT federicopiofabrizio mixedpulmonaryadenocarcinomaandatypicalcarcinoidareportoftwocasesofanoncodifiedentitywithbiologicalprofile AT antonellacentonza mixedpulmonaryadenocarcinomaandatypicalcarcinoidareportoftwocasesofanoncodifiedentitywithbiologicalprofile AT marcotaurchini mixedpulmonaryadenocarcinomaandatypicalcarcinoidareportoftwocasesofanoncodifiedentitywithbiologicalprofile AT tommasomazza mixedpulmonaryadenocarcinomaandatypicalcarcinoidareportoftwocasesofanoncodifiedentitywithbiologicalprofile AT mauriziocassano mixedpulmonaryadenocarcinomaandatypicalcarcinoidareportoftwocasesofanoncodifiedentitywithbiologicalprofile AT giuseppemiscio mixedpulmonaryadenocarcinomaandatypicalcarcinoidareportoftwocasesofanoncodifiedentitywithbiologicalprofile AT flaviacentra mixedpulmonaryadenocarcinomaandatypicalcarcinoidareportoftwocasesofanoncodifiedentitywithbiologicalprofile AT gianmariaferretti mixedpulmonaryadenocarcinomaandatypicalcarcinoidareportoftwocasesofanoncodifiedentitywithbiologicalprofile AT concettamartinadimicco mixedpulmonaryadenocarcinomaandatypicalcarcinoidareportoftwocasesofanoncodifiedentitywithbiologicalprofile AT paolograziano mixedpulmonaryadenocarcinomaandatypicalcarcinoidareportoftwocasesofanoncodifiedentitywithbiologicalprofile AT luciaannamuscarella mixedpulmonaryadenocarcinomaandatypicalcarcinoidareportoftwocasesofanoncodifiedentitywithbiologicalprofile
_version_	1718373933795770368

Mixed Pulmonary Adenocarcinoma and Atypical Carcinoid: A Report of Two Cases of a Non-codified Entity With Biological Profile

Ejemplares similares