Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study

Objective:Late neonatal hypocalcemia (LNH) is a common metabolic problem associated with hypoparathyroidism, high phosphate intake and vitamin D deficiency, often presenting with seizures. In this cross-sectional study, we aimed to evaluate the role of vitamin D deficiency in LNH in Turkey and to de...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Gülcan Seymen-Karabulut, Ayla Günlemez, Ayşe Sevim Gökalp, Şükrü Hatun, Fatma Kaya Narter, Mehmet Mutlu, Şebnem Kader, Demet Terek, Deniz Hanta, Emel Okulu, Leyla Karadeniz, H. Gözde Kanmaz Kutman, Ayşegül Zenciroğlu, Özmert M. A. Özdemir, Dilek Sarıcı, Muhittin Çelik, Nihat Demir, Özden Turan, Kıymet Çelik, Fatih Kılıçbay, Sinan Uslu, Sara Erol, Sabahattin Ertuğrul, Ilkay Er, Hasan Tolga Çelik, Merih Çetinkaya, Filiz Aktürk-Acar, Yakup Aslan, Gaffari Tunç, Ömer Güran, Ayşe Engin Arısoy
Formato: article
Lenguaje:EN
Publicado: Galenos Yayincilik 2021
Materias:
Acceso en línea:https://doaj.org/article/646b7b0dc6e8458eb2d024d4ea2c5f3e
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:646b7b0dc6e8458eb2d024d4ea2c5f3e
record_format dspace
spelling oai:doaj.org-article:646b7b0dc6e8458eb2d024d4ea2c5f3e2021-11-26T06:10:16ZVitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study1308-57271308-573510.4274/jcrpe.galenos.2020.2021.0169https://doaj.org/article/646b7b0dc6e8458eb2d024d4ea2c5f3e2021-12-01T00:00:00Z http://www.jcrpe.org/archives/archive-detail/article-preview/vitamin-d-deficiency-prevalence-in-late-neonatal-h/47423 https://doaj.org/toc/1308-5727https://doaj.org/toc/1308-5735Objective:Late neonatal hypocalcemia (LNH) is a common metabolic problem associated with hypoparathyroidism, high phosphate intake and vitamin D deficiency, often presenting with seizures. In this cross-sectional study, we aimed to evaluate the role of vitamin D deficiency in LNH in Turkey and to describe the characteristics of affected newborns.Methods:Conducted with a cross-sectional design and with the participation of 61 neonatal centers from December 2015 to December 2016, the study included term neonates with LNH (n=96) and their mothers (n=93). Data were registered on the FAVOR Web Registry System. Serum samples of newborns and mothers were analyzed for calcium, phosphate, magnesium, albumin, alkaline phosphatase, intact parathyroid hormone (iPTH) and 25 hydroxyvitamin D [25(OH)D] levels.Results:The median (range) onset time of hypocalcemia was 5.0 (4.0-8.0) days of age, with a male preponderance (60.4%). The median (range) serum 25(OH)D levels of the neonates and their mothers were 6.3 (4.1-9.05) and 5.2 (4.7-8.8) ng/mL, respectively. The prevalence of vitamin D deficiency (<12 ng/mL) was high in both the neonates (86.5%) and mothers (93%). Serum 25(OH)D levels of the infants and mothers showed a strong correlation (p<0.001). While the majority (93.7%) of the neonates had normal/high phosphorus levels, iPTH levels were low or inappropriately normal in 54.2% of the patients.Conclusion:Vitamin D deficiency prevalence was found to be high in LNH. Efforts to provide vitamin D supplementation during pregnancy should be encouraged. Evaluation of vitamin D status should be included in the workup of LNH.Gülcan Seymen-KarabulutAyla GünlemezAyşe Sevim GökalpŞükrü HatunFatma Kaya NarterMehmet MutluŞebnem KaderDemet TerekDeniz HantaEmel OkuluLeyla KaradenizH. Gözde Kanmaz KutmanAyşegül ZenciroğluÖzmert M. A. ÖzdemirDilek SarıcıMuhittin ÇelikNihat DemirÖzden TuranKıymet ÇelikFatih KılıçbaySinan UsluSara ErolSabahattin ErtuğrulIlkay ErHasan Tolga ÇelikMerih ÇetinkayaFiliz Aktürk-AcarYakup AslanGaffari TunçÖmer GüranAyşe Engin ArısoyGalenos Yayincilikarticlevitamin d deficiencyhypocalcemiainfantnewbornPediatricsRJ1-570Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENJCRPE, Vol 13, Iss 4, Pp 384-390 (2021)
institution DOAJ
collection DOAJ
language EN
topic vitamin d deficiency
hypocalcemia
infant
newborn
Pediatrics
RJ1-570
Diseases of the endocrine glands. Clinical endocrinology
RC648-665
spellingShingle vitamin d deficiency
hypocalcemia
infant
newborn
Pediatrics
RJ1-570
Diseases of the endocrine glands. Clinical endocrinology
RC648-665
Gülcan Seymen-Karabulut
Ayla Günlemez
Ayşe Sevim Gökalp
Şükrü Hatun
Fatma Kaya Narter
Mehmet Mutlu
Şebnem Kader
Demet Terek
Deniz Hanta
Emel Okulu
Leyla Karadeniz
H. Gözde Kanmaz Kutman
Ayşegül Zenciroğlu
Özmert M. A. Özdemir
Dilek Sarıcı
Muhittin Çelik
Nihat Demir
Özden Turan
Kıymet Çelik
Fatih Kılıçbay
Sinan Uslu
Sara Erol
Sabahattin Ertuğrul
Ilkay Er
Hasan Tolga Çelik
Merih Çetinkaya
Filiz Aktürk-Acar
Yakup Aslan
Gaffari Tunç
Ömer Güran
Ayşe Engin Arısoy
Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study
description Objective:Late neonatal hypocalcemia (LNH) is a common metabolic problem associated with hypoparathyroidism, high phosphate intake and vitamin D deficiency, often presenting with seizures. In this cross-sectional study, we aimed to evaluate the role of vitamin D deficiency in LNH in Turkey and to describe the characteristics of affected newborns.Methods:Conducted with a cross-sectional design and with the participation of 61 neonatal centers from December 2015 to December 2016, the study included term neonates with LNH (n=96) and their mothers (n=93). Data were registered on the FAVOR Web Registry System. Serum samples of newborns and mothers were analyzed for calcium, phosphate, magnesium, albumin, alkaline phosphatase, intact parathyroid hormone (iPTH) and 25 hydroxyvitamin D [25(OH)D] levels.Results:The median (range) onset time of hypocalcemia was 5.0 (4.0-8.0) days of age, with a male preponderance (60.4%). The median (range) serum 25(OH)D levels of the neonates and their mothers were 6.3 (4.1-9.05) and 5.2 (4.7-8.8) ng/mL, respectively. The prevalence of vitamin D deficiency (<12 ng/mL) was high in both the neonates (86.5%) and mothers (93%). Serum 25(OH)D levels of the infants and mothers showed a strong correlation (p<0.001). While the majority (93.7%) of the neonates had normal/high phosphorus levels, iPTH levels were low or inappropriately normal in 54.2% of the patients.Conclusion:Vitamin D deficiency prevalence was found to be high in LNH. Efforts to provide vitamin D supplementation during pregnancy should be encouraged. Evaluation of vitamin D status should be included in the workup of LNH.
format article
author Gülcan Seymen-Karabulut
Ayla Günlemez
Ayşe Sevim Gökalp
Şükrü Hatun
Fatma Kaya Narter
Mehmet Mutlu
Şebnem Kader
Demet Terek
Deniz Hanta
Emel Okulu
Leyla Karadeniz
H. Gözde Kanmaz Kutman
Ayşegül Zenciroğlu
Özmert M. A. Özdemir
Dilek Sarıcı
Muhittin Çelik
Nihat Demir
Özden Turan
Kıymet Çelik
Fatih Kılıçbay
Sinan Uslu
Sara Erol
Sabahattin Ertuğrul
Ilkay Er
Hasan Tolga Çelik
Merih Çetinkaya
Filiz Aktürk-Acar
Yakup Aslan
Gaffari Tunç
Ömer Güran
Ayşe Engin Arısoy
author_facet Gülcan Seymen-Karabulut
Ayla Günlemez
Ayşe Sevim Gökalp
Şükrü Hatun
Fatma Kaya Narter
Mehmet Mutlu
Şebnem Kader
Demet Terek
Deniz Hanta
Emel Okulu
Leyla Karadeniz
H. Gözde Kanmaz Kutman
Ayşegül Zenciroğlu
Özmert M. A. Özdemir
Dilek Sarıcı
Muhittin Çelik
Nihat Demir
Özden Turan
Kıymet Çelik
Fatih Kılıçbay
Sinan Uslu
Sara Erol
Sabahattin Ertuğrul
Ilkay Er
Hasan Tolga Çelik
Merih Çetinkaya
Filiz Aktürk-Acar
Yakup Aslan
Gaffari Tunç
Ömer Güran
Ayşe Engin Arısoy
author_sort Gülcan Seymen-Karabulut
title Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study
title_short Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study
title_full Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study
title_fullStr Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study
title_full_unstemmed Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study
title_sort vitamin d deficiency prevalence in late neonatal hypocalcemia: a multicenter study
publisher Galenos Yayincilik
publishDate 2021
url https://doaj.org/article/646b7b0dc6e8458eb2d024d4ea2c5f3e
work_keys_str_mv AT gulcanseymenkarabulut vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT aylagunlemez vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT aysesevimgokalp vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT sukruhatun vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT fatmakayanarter vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT mehmetmutlu vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT sebnemkader vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT demetterek vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT denizhanta vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT emelokulu vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT leylakaradeniz vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT hgozdekanmazkutman vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT aysegulzenciroglu vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT ozmertmaozdemir vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT dileksarıcı vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT muhittincelik vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT nihatdemir vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT ozdenturan vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT kıymetcelik vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT fatihkılıcbay vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT sinanuslu vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT saraerol vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT sabahattinertugrul vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT ilkayer vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT hasantolgacelik vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT merihcetinkaya vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT filizakturkacar vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT yakupaslan vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT gaffaritunc vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT omerguran vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
AT ayseenginarısoy vitaminddeficiencyprevalenceinlateneonatalhypocalcemiaamulticenterstudy
_version_ 1718409780902494208