The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.

Substance dependence or addiction is a complex environmental and genetic disorder that results in serious health and socio-economic consequences. Multiple substance dependence categories together, rather than any one individual addiction outcome, may explain the genetic variability of such disorder....

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Autores principales:	Xiang Chen, Kelly Cho, Burton H Singer, Heping Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6472ed024376496dbec76faee31ee984
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spelling	oai:doaj.org-article:6472ed024376496dbec76faee31ee9842021-11-18T06:59:44ZThe nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.1932-620310.1371/journal.pone.0016002https://doaj.org/article/6472ed024376496dbec76faee31ee9842011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21298047/?tool=EBIhttps://doaj.org/toc/1932-6203Substance dependence or addiction is a complex environmental and genetic disorder that results in serious health and socio-economic consequences. Multiple substance dependence categories together, rather than any one individual addiction outcome, may explain the genetic variability of such disorder. In our study, we defined a composite substance dependence phenotype derived from six individual diagnoses: addiction to nicotine, alcohol, marijuana, cocaine, opiates or other drugs as a whole. Using data from several genomewide case-control studies, we identified a strong (Odds ratio = 1.77) and significant (p-value = 7E-8) association signal with a novel gene, PBX/knotted 1 homeobox 2 (PKNOX2), on chromosome 11 with the composite phenotype in European-origin women. The association signal is not as significant when individual outcomes for addiction are considered, or in males or African-origin population. Our findings underscore the importance of considering multiple addiction types and the importance of considering population and gender stratification when analyzing data with heterogeneous population.Xiang ChenKelly ChoBurton H SingerHeping ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 1, p e16002 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiang Chen Kelly Cho Burton H Singer Heping Zhang The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.
description	Substance dependence or addiction is a complex environmental and genetic disorder that results in serious health and socio-economic consequences. Multiple substance dependence categories together, rather than any one individual addiction outcome, may explain the genetic variability of such disorder. In our study, we defined a composite substance dependence phenotype derived from six individual diagnoses: addiction to nicotine, alcohol, marijuana, cocaine, opiates or other drugs as a whole. Using data from several genomewide case-control studies, we identified a strong (Odds ratio = 1.77) and significant (p-value = 7E-8) association signal with a novel gene, PBX/knotted 1 homeobox 2 (PKNOX2), on chromosome 11 with the composite phenotype in European-origin women. The association signal is not as significant when individual outcomes for addiction are considered, or in males or African-origin population. Our findings underscore the importance of considering multiple addiction types and the importance of considering population and gender stratification when analyzing data with heterogeneous population.
format	article
author	Xiang Chen Kelly Cho Burton H Singer Heping Zhang
author_facet	Xiang Chen Kelly Cho Burton H Singer Heping Zhang
author_sort	Xiang Chen
title	The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.
title_short	The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.
title_full	The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.
title_fullStr	The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.
title_full_unstemmed	The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.
title_sort	nuclear transcription factor pknox2 is a candidate gene for substance dependence in european-origin women.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/6472ed024376496dbec76faee31ee984
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The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.

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