Genomic and metabolomic profile associated to microalbuminuria.

To identify factors related with the risk to develop microalbuminuria using combined genomic and metabolomic values from a general population study. One thousand five hundred and two subjects, Caucasian, more than 18 years, representative of the general population, were included. Blood pressure meas...

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Autores principales: Vannina G Marrachelli, Daniel Monleon, Pilar Rentero, María L Mansego, Jose Manuel Morales, Inma Galan, Remedios Segura, Fernando Martinez, Juan Carlos Martin-Escudero, Laisa Briongos, Pablo Marin, Gloria Lliso, Felipe Javier Chaves, Josep Redon
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Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/6472fc0c8367437989d958b580537ea2
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spelling oai:doaj.org-article:6472fc0c8367437989d958b580537ea22021-11-18T08:16:09ZGenomic and metabolomic profile associated to microalbuminuria.1932-620310.1371/journal.pone.0098227https://doaj.org/article/6472fc0c8367437989d958b580537ea22014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24918908/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203To identify factors related with the risk to develop microalbuminuria using combined genomic and metabolomic values from a general population study. One thousand five hundred and two subjects, Caucasian, more than 18 years, representative of the general population, were included. Blood pressure measurement and albumin/creatinine ratio were measured in a urine sample. Using SNPlex, 1251 SNPs potentially associated to urinary albumin excretion (UAE) were analyzed. Serum metabolomic profile was assessed by 1H NMR spectra using a Brucker Advance DRX 600 spectrometer. From the total population, 1217 (mean age 54 ± 19, 50.6% men, ACR>30 mg/g in 81 subjects) with high genotyping call rate were analysed. A characteristic metabolomic profile, which included products from mitochondrial and extra mitochondrial metabolism as well as branched amino acids and their derivative signals, were observed in microalbuminuric as compare to normoalbuminuric subjects. The comparison of the metabolomic profile between subjects with different UAE status for each of the genotypes associated to microalbuminuria revealed two SNPs, the rs10492025_TT of RPH3A gene and the rs4359_CC of ACE gene, with minimal or no statistically significant differences. Subjects with and without microalbuminuria, who shared the same genotype and metabolomic profile, differed in age. Microalbuminurics with the CC genotype of the rs4359 polymorphism and with the TT genotype of the rs10492025 polymorphism were seven years older and seventeen years younger, respectively as compared to the whole microalbuminuric subjects. With the same metabolomic environment, characteristic of subjects with microalbuminuria, the TT genotype of the rs10492025 polymorphism seems to increase and the CC genotype of the rs4359 polymorphism seems to reduce risk to develop microalbuminuria.Vannina G MarrachelliDaniel MonleonPilar RenteroMaría L MansegoJose Manuel MoralesInma GalanRemedios SeguraFernando MartinezJuan Carlos Martin-EscuderoLaisa BriongosPablo MarinGloria LlisoFelipe Javier ChavesJosep RedonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e98227 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Vannina G Marrachelli
Daniel Monleon
Pilar Rentero
María L Mansego
Jose Manuel Morales
Inma Galan
Remedios Segura
Fernando Martinez
Juan Carlos Martin-Escudero
Laisa Briongos
Pablo Marin
Gloria Lliso
Felipe Javier Chaves
Josep Redon
Genomic and metabolomic profile associated to microalbuminuria.
description To identify factors related with the risk to develop microalbuminuria using combined genomic and metabolomic values from a general population study. One thousand five hundred and two subjects, Caucasian, more than 18 years, representative of the general population, were included. Blood pressure measurement and albumin/creatinine ratio were measured in a urine sample. Using SNPlex, 1251 SNPs potentially associated to urinary albumin excretion (UAE) were analyzed. Serum metabolomic profile was assessed by 1H NMR spectra using a Brucker Advance DRX 600 spectrometer. From the total population, 1217 (mean age 54 ± 19, 50.6% men, ACR>30 mg/g in 81 subjects) with high genotyping call rate were analysed. A characteristic metabolomic profile, which included products from mitochondrial and extra mitochondrial metabolism as well as branched amino acids and their derivative signals, were observed in microalbuminuric as compare to normoalbuminuric subjects. The comparison of the metabolomic profile between subjects with different UAE status for each of the genotypes associated to microalbuminuria revealed two SNPs, the rs10492025_TT of RPH3A gene and the rs4359_CC of ACE gene, with minimal or no statistically significant differences. Subjects with and without microalbuminuria, who shared the same genotype and metabolomic profile, differed in age. Microalbuminurics with the CC genotype of the rs4359 polymorphism and with the TT genotype of the rs10492025 polymorphism were seven years older and seventeen years younger, respectively as compared to the whole microalbuminuric subjects. With the same metabolomic environment, characteristic of subjects with microalbuminuria, the TT genotype of the rs10492025 polymorphism seems to increase and the CC genotype of the rs4359 polymorphism seems to reduce risk to develop microalbuminuria.
format article
author Vannina G Marrachelli
Daniel Monleon
Pilar Rentero
María L Mansego
Jose Manuel Morales
Inma Galan
Remedios Segura
Fernando Martinez
Juan Carlos Martin-Escudero
Laisa Briongos
Pablo Marin
Gloria Lliso
Felipe Javier Chaves
Josep Redon
author_facet Vannina G Marrachelli
Daniel Monleon
Pilar Rentero
María L Mansego
Jose Manuel Morales
Inma Galan
Remedios Segura
Fernando Martinez
Juan Carlos Martin-Escudero
Laisa Briongos
Pablo Marin
Gloria Lliso
Felipe Javier Chaves
Josep Redon
author_sort Vannina G Marrachelli
title Genomic and metabolomic profile associated to microalbuminuria.
title_short Genomic and metabolomic profile associated to microalbuminuria.
title_full Genomic and metabolomic profile associated to microalbuminuria.
title_fullStr Genomic and metabolomic profile associated to microalbuminuria.
title_full_unstemmed Genomic and metabolomic profile associated to microalbuminuria.
title_sort genomic and metabolomic profile associated to microalbuminuria.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/6472fc0c8367437989d958b580537ea2
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