microRNA-26a represses pancreatic cancer cell malignant behaviors by targeting E2F7

Abstract Dysregulation of microRNAs (miRNAs) exerts key roles in the development of pancreatic cancer (PCa). miR-26a is reportedly a tumor suppressor in cancers. However, whether miR-26a modulates PCa progression is poorly understood. Here, we found that miR-26a was down-regulated in PCa. Overexpres...

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Autores principales:	Liang Wang, Meijun Li, Fei Chen
Formato:	article
Lenguaje:	EN
Publicado:	Springer 2021
Materias:	miR-26a Pancreatic cancer E2F7 VEGFA Cell proliferation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/64735ed4c3074fc2af4b6d8c25ef1d72
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spelling	oai:doaj.org-article:64735ed4c3074fc2af4b6d8c25ef1d722021-11-28T12:42:08ZmicroRNA-26a represses pancreatic cancer cell malignant behaviors by targeting E2F710.1007/s12672-021-00448-z2730-6011https://doaj.org/article/64735ed4c3074fc2af4b6d8c25ef1d722021-11-01T00:00:00Zhttps://doi.org/10.1007/s12672-021-00448-zhttps://doaj.org/toc/2730-6011Abstract Dysregulation of microRNAs (miRNAs) exerts key roles in the development of pancreatic cancer (PCa). miR-26a is reportedly a tumor suppressor in cancers. However, whether miR-26a modulates PCa progression is poorly understood. Here, we found that miR-26a was down-regulated in PCa. Overexpressed miR-26a suppressed PCa cell proliferation, colony formation, and tumor stem cell properties. Mechanically, the transcription factor E2F7 is a downstream target of miR-26a. miR-26a decreased E2F7 expression through binding to the 3’-untranslated region (UTR) of E2F7. Decreased miR-26a in PCa tissues was inversely correlated with E2F7. The inhibitory effects of miR-26a in PCa were reversed by E2F7 overexpression. Consistently, the knockout of E2F7 further significantly inhibited the growth of PCa cells combined with miR-26a overexpression. Further study revealed that E2F7 bound the promoter of vascular endothelial growth factor A (VEGFA), a key factor in angiogenesis, and transcriptionally activated the expression of VEGFA. miR-26a overexpression attenuated the effects of E2F7 on VEGFA promotion. Our results uncovered the novel function of miR-26a/E2F7/VEGFA in PCa, making miR-26a a possible target for PCa treatment.Liang WangMeijun LiFei ChenSpringerarticlemiR-26aPancreatic cancerE2F7VEGFACell proliferationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENDiscover Oncology, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	miR-26a Pancreatic cancer E2F7 VEGFA Cell proliferation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	miR-26a Pancreatic cancer E2F7 VEGFA Cell proliferation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Liang Wang Meijun Li Fei Chen microRNA-26a represses pancreatic cancer cell malignant behaviors by targeting E2F7
description	Abstract Dysregulation of microRNAs (miRNAs) exerts key roles in the development of pancreatic cancer (PCa). miR-26a is reportedly a tumor suppressor in cancers. However, whether miR-26a modulates PCa progression is poorly understood. Here, we found that miR-26a was down-regulated in PCa. Overexpressed miR-26a suppressed PCa cell proliferation, colony formation, and tumor stem cell properties. Mechanically, the transcription factor E2F7 is a downstream target of miR-26a. miR-26a decreased E2F7 expression through binding to the 3’-untranslated region (UTR) of E2F7. Decreased miR-26a in PCa tissues was inversely correlated with E2F7. The inhibitory effects of miR-26a in PCa were reversed by E2F7 overexpression. Consistently, the knockout of E2F7 further significantly inhibited the growth of PCa cells combined with miR-26a overexpression. Further study revealed that E2F7 bound the promoter of vascular endothelial growth factor A (VEGFA), a key factor in angiogenesis, and transcriptionally activated the expression of VEGFA. miR-26a overexpression attenuated the effects of E2F7 on VEGFA promotion. Our results uncovered the novel function of miR-26a/E2F7/VEGFA in PCa, making miR-26a a possible target for PCa treatment.
format	article
author	Liang Wang Meijun Li Fei Chen
author_facet	Liang Wang Meijun Li Fei Chen
author_sort	Liang Wang
title	microRNA-26a represses pancreatic cancer cell malignant behaviors by targeting E2F7
title_short	microRNA-26a represses pancreatic cancer cell malignant behaviors by targeting E2F7
title_full	microRNA-26a represses pancreatic cancer cell malignant behaviors by targeting E2F7
title_fullStr	microRNA-26a represses pancreatic cancer cell malignant behaviors by targeting E2F7
title_full_unstemmed	microRNA-26a represses pancreatic cancer cell malignant behaviors by targeting E2F7
title_sort	microrna-26a represses pancreatic cancer cell malignant behaviors by targeting e2f7
publisher	Springer
publishDate	2021
url	https://doaj.org/article/64735ed4c3074fc2af4b6d8c25ef1d72
work_keys_str_mv	AT liangwang microrna26arepressespancreaticcancercellmalignantbehaviorsbytargetinge2f7 AT meijunli microrna26arepressespancreaticcancercellmalignantbehaviorsbytargetinge2f7 AT feichen microrna26arepressespancreaticcancercellmalignantbehaviorsbytargetinge2f7
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microRNA-26a represses pancreatic cancer cell malignant behaviors by targeting E2F7

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