Mean platelet volume in bipolar disorder: the search for an ideal biomarker

Derya Guliz Mert,1 Hatice Terzi2 1Department of Psychiatry, 2Department of Hematology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey Background: The pathophysiology of bipolar disorder (BD) remains a mystery. In this context, interest in the role of the immune and inflammatory systems...

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Autores principales:	Mert DG, Terzi H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	bipolar disorder inflammation mean platelet volume Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/64759c9cee404d5498eb9943a6f3d818
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spelling	oai:doaj.org-article:64759c9cee404d5498eb9943a6f3d8182021-12-02T04:22:30ZMean platelet volume in bipolar disorder: the search for an ideal biomarker1178-2021https://doaj.org/article/64759c9cee404d5498eb9943a6f3d8182016-08-01T00:00:00Zhttps://www.dovepress.com/mean-platelet-volume-in-bipolar-disorder-the-search-for-an-ideal-bioma-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Derya Guliz Mert,1 Hatice Terzi2 1Department of Psychiatry, 2Department of Hematology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey Background: The pathophysiology of bipolar disorder (BD) remains a mystery. In this context, interest in the role of the immune and inflammatory systems in BD has been increasing. We aimed to compare the routine hemogram values of BD patients with those of the participants in the healthy control group, to assess the inflammation levels of the two groups. Mean platelet volume (MPV) can be obtained as routine hemogram parameters and may aid in the detection of systemic inflammation. Subjects and methods: This study was conducted with BD (manic episode) inpatients (n=132) and healthy controls (n=135). Abnormally distributed variables (ie, neutrophil–lymphocyte ratio [NLR], platelet–lymphocyte ratio [PLR], neutrophils, lymphocytes, hemoglobin, hematocrit [HCT], mean corpuscular volume [MCV], mean corpuscular hemoglobin [MCH], mean corpuscular hemoglobin concentration [MCHC], red cell distribution width [RDW], MPV, and plateletcrit [PCT]) were compared using the Mann–Whitney U-test. Student’s t-test was used to compare the mean ages and white blood cell, red blood cell, and platelet counts of the patients with BD against those of the participants in the control group. Results: The comparisons revealed that while the mean WBC and the median NLR, PLR, neutrophil, lymphocyte, MPV, and PCT values were significantly higher in the patients with BD (P<0.05), the median hemoglobin, RBC, HCT, and MCHC values were significantly higher in the control group (P<0.05). Conclusion: Comparisons of hemogram values of patients with BD against those of the healthy control group revealed that inflammatory cells (absolute neutrophil count, platelet count, PCT, and MPV) and ratios (NLR, PLR) seem to be altered during manic episodes. These findings support the hypothesis that inflammatory activation occurs in BD during manic episodes. In addition to NLR and PLR, MPV may be useful in the detection of this activation. The most significant limitation in the study is that smokers were not excluded in both groups. The development of new preventive and therapeutic options can be facilitated through the understanding of this mechanism because through this mechanism, inflammation may pathologically affect brain function, as well as inducing and/or perpetuating BD. Keywords: bipolar disorder, inflammation, mean platelet volumeMert DGTerzi HDove Medical Pressarticlebipolar disorderinflammationmean platelet volumeNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2057-2062 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	bipolar disorder inflammation mean platelet volume Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	bipolar disorder inflammation mean platelet volume Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Mert DG Terzi H Mean platelet volume in bipolar disorder: the search for an ideal biomarker
description	Derya Guliz Mert,1 Hatice Terzi2 1Department of Psychiatry, 2Department of Hematology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey Background: The pathophysiology of bipolar disorder (BD) remains a mystery. In this context, interest in the role of the immune and inflammatory systems in BD has been increasing. We aimed to compare the routine hemogram values of BD patients with those of the participants in the healthy control group, to assess the inflammation levels of the two groups. Mean platelet volume (MPV) can be obtained as routine hemogram parameters and may aid in the detection of systemic inflammation. Subjects and methods: This study was conducted with BD (manic episode) inpatients (n=132) and healthy controls (n=135). Abnormally distributed variables (ie, neutrophil–lymphocyte ratio [NLR], platelet–lymphocyte ratio [PLR], neutrophils, lymphocytes, hemoglobin, hematocrit [HCT], mean corpuscular volume [MCV], mean corpuscular hemoglobin [MCH], mean corpuscular hemoglobin concentration [MCHC], red cell distribution width [RDW], MPV, and plateletcrit [PCT]) were compared using the Mann–Whitney U-test. Student’s t-test was used to compare the mean ages and white blood cell, red blood cell, and platelet counts of the patients with BD against those of the participants in the control group. Results: The comparisons revealed that while the mean WBC and the median NLR, PLR, neutrophil, lymphocyte, MPV, and PCT values were significantly higher in the patients with BD (P<0.05), the median hemoglobin, RBC, HCT, and MCHC values were significantly higher in the control group (P<0.05). Conclusion: Comparisons of hemogram values of patients with BD against those of the healthy control group revealed that inflammatory cells (absolute neutrophil count, platelet count, PCT, and MPV) and ratios (NLR, PLR) seem to be altered during manic episodes. These findings support the hypothesis that inflammatory activation occurs in BD during manic episodes. In addition to NLR and PLR, MPV may be useful in the detection of this activation. The most significant limitation in the study is that smokers were not excluded in both groups. The development of new preventive and therapeutic options can be facilitated through the understanding of this mechanism because through this mechanism, inflammation may pathologically affect brain function, as well as inducing and/or perpetuating BD. Keywords: bipolar disorder, inflammation, mean platelet volume
format	article
author	Mert DG Terzi H
author_facet	Mert DG Terzi H
author_sort	Mert DG
title	Mean platelet volume in bipolar disorder: the search for an ideal biomarker
title_short	Mean platelet volume in bipolar disorder: the search for an ideal biomarker
title_full	Mean platelet volume in bipolar disorder: the search for an ideal biomarker
title_fullStr	Mean platelet volume in bipolar disorder: the search for an ideal biomarker
title_full_unstemmed	Mean platelet volume in bipolar disorder: the search for an ideal biomarker
title_sort	mean platelet volume in bipolar disorder: the search for an ideal biomarker
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/64759c9cee404d5498eb9943a6f3d818
work_keys_str_mv	AT mertdg meanplateletvolumeinbipolardisorderthesearchforanidealbiomarker AT terzih meanplateletvolumeinbipolardisorderthesearchforanidealbiomarker
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Mean platelet volume in bipolar disorder: the search for an ideal biomarker

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