Half-dose photodynamic therapy for serous non-neovascular retinal pigment epithelial detachment

Satoru Inoda,1 Hidenori Takahashi,1 Yuji Inoue,1 Hironobu Tampo,1 Shinichi Sakamoto,1 Yusuke Arai,1 Hidetoshi Kawashima,1 Yasuo Yanagi21Ophthalmology, Jichi Medical University, Shimotsuke-Shi, Tochigi, 329-0431, Japan; 2Ophthalmology, Asahikawa Medical University, Asahikawa-Shi, Hokkaido, 078-8510,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Inoda S, Takahashi H, Inoue Y, Tampo H, Sakamoto S, Arai Y, Kawashima H, Yanagi Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	epithelial detachment serous pigment epithelial detachment non-neovascular pigment photodynamic therapy photodynamic therapy Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/64761463e9f64943aa1503d56c0739e9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:64761463e9f64943aa1503d56c0739e9
record_format	dspace
spelling	oai:doaj.org-article:64761463e9f64943aa1503d56c0739e92021-12-02T03:07:19ZHalf-dose photodynamic therapy for serous non-neovascular retinal pigment epithelial detachment1177-5483https://doaj.org/article/64761463e9f64943aa1503d56c0739e92019-06-01T00:00:00Zhttps://www.dovepress.com/half-dose-photodynamic-therapy-for-serous-non-neovascular-retinal-pigm-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Satoru Inoda,1 Hidenori Takahashi,1 Yuji Inoue,1 Hironobu Tampo,1 Shinichi Sakamoto,1 Yusuke Arai,1 Hidetoshi Kawashima,1 Yasuo Yanagi21Ophthalmology, Jichi Medical University, Shimotsuke-Shi, Tochigi, 329-0431, Japan; 2Ophthalmology, Asahikawa Medical University, Asahikawa-Shi, Hokkaido, 078-8510, JapanPurpose: To investigate the efficacy of half-dose photodynamic therapy (PDT) for treating symptomatic serous non-neovascular pigment epithelial detachment (PED) and to identify factors associated with treatment outcome.Patients and methods: This is a single-institute retrospective case series involving 12 eyes of 12 consecutive patients with serous non-neovascular PED who received half-dose PDT. We investigated the temporal change in best-corrected visual acuity (BCVA), the anatomic outcomes of PED, including recurrence, central choroidal thickness (CCT), and also choroidal thickness as a possible factor associated with treatment outcome.Results: At baseline, mean logMAR BCVA was 0.06 (range Snellen equivalent 6/20 to 24/20); 24 months later, it was 0.01 (Snellen equivalent 6/20 to 24/20; P=0.3). At 3 months, PED had completely flattened in 8, decreased in height in 2, and remained unchanged in 2. The CCT in eyes with PED was 410 μm and thicker than that in fellow eyes (290 μm, P<0.0001). Recurrence was noted in 2 within 12 months after treatment. Eyes in which the choroidal thickness with a baseline CCT >350μm or a 100 μm difference in CCT responded favorably to half-dose PDT (P=0.02).Conclusion: Half-dose PDT is effective in patients with non-neovascular PED. Thicker choroid and some difference in CCT between affected and fellow eye might be a good index for predicting the efficacy of this treatment.Keywords: epithelial detachment, serous pigment epithelial detachment, non-neovascular pigment photodynamic therapy, photodynamic therapyInoda STakahashi HInoue YTampo HSakamoto SArai YKawashima HYanagi YDove Medical Pressarticleepithelial detachmentserous pigment epithelial detachmentnon-neovascular pigment photodynamic therapyphotodynamic therapyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 959-968 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	epithelial detachment serous pigment epithelial detachment non-neovascular pigment photodynamic therapy photodynamic therapy Ophthalmology RE1-994
spellingShingle	epithelial detachment serous pigment epithelial detachment non-neovascular pigment photodynamic therapy photodynamic therapy Ophthalmology RE1-994 Inoda S Takahashi H Inoue Y Tampo H Sakamoto S Arai Y Kawashima H Yanagi Y Half-dose photodynamic therapy for serous non-neovascular retinal pigment epithelial detachment
description	Satoru Inoda,1 Hidenori Takahashi,1 Yuji Inoue,1 Hironobu Tampo,1 Shinichi Sakamoto,1 Yusuke Arai,1 Hidetoshi Kawashima,1 Yasuo Yanagi21Ophthalmology, Jichi Medical University, Shimotsuke-Shi, Tochigi, 329-0431, Japan; 2Ophthalmology, Asahikawa Medical University, Asahikawa-Shi, Hokkaido, 078-8510, JapanPurpose: To investigate the efficacy of half-dose photodynamic therapy (PDT) for treating symptomatic serous non-neovascular pigment epithelial detachment (PED) and to identify factors associated with treatment outcome.Patients and methods: This is a single-institute retrospective case series involving 12 eyes of 12 consecutive patients with serous non-neovascular PED who received half-dose PDT. We investigated the temporal change in best-corrected visual acuity (BCVA), the anatomic outcomes of PED, including recurrence, central choroidal thickness (CCT), and also choroidal thickness as a possible factor associated with treatment outcome.Results: At baseline, mean logMAR BCVA was 0.06 (range Snellen equivalent 6/20 to 24/20); 24 months later, it was 0.01 (Snellen equivalent 6/20 to 24/20; P=0.3). At 3 months, PED had completely flattened in 8, decreased in height in 2, and remained unchanged in 2. The CCT in eyes with PED was 410 μm and thicker than that in fellow eyes (290 μm, P<0.0001). Recurrence was noted in 2 within 12 months after treatment. Eyes in which the choroidal thickness with a baseline CCT >350μm or a 100 μm difference in CCT responded favorably to half-dose PDT (P=0.02).Conclusion: Half-dose PDT is effective in patients with non-neovascular PED. Thicker choroid and some difference in CCT between affected and fellow eye might be a good index for predicting the efficacy of this treatment.Keywords: epithelial detachment, serous pigment epithelial detachment, non-neovascular pigment photodynamic therapy, photodynamic therapy
format	article
author	Inoda S Takahashi H Inoue Y Tampo H Sakamoto S Arai Y Kawashima H Yanagi Y
author_facet	Inoda S Takahashi H Inoue Y Tampo H Sakamoto S Arai Y Kawashima H Yanagi Y
author_sort	Inoda S
title	Half-dose photodynamic therapy for serous non-neovascular retinal pigment epithelial detachment
title_short	Half-dose photodynamic therapy for serous non-neovascular retinal pigment epithelial detachment
title_full	Half-dose photodynamic therapy for serous non-neovascular retinal pigment epithelial detachment
title_fullStr	Half-dose photodynamic therapy for serous non-neovascular retinal pigment epithelial detachment
title_full_unstemmed	Half-dose photodynamic therapy for serous non-neovascular retinal pigment epithelial detachment
title_sort	half-dose photodynamic therapy for serous non-neovascular retinal pigment epithelial detachment
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/64761463e9f64943aa1503d56c0739e9
work_keys_str_mv	AT inodas halfdosephotodynamictherapyforserousnonneovascularretinalpigmentepithelialdetachment AT takahashih halfdosephotodynamictherapyforserousnonneovascularretinalpigmentepithelialdetachment AT inouey halfdosephotodynamictherapyforserousnonneovascularretinalpigmentepithelialdetachment AT tampoh halfdosephotodynamictherapyforserousnonneovascularretinalpigmentepithelialdetachment AT sakamotos halfdosephotodynamictherapyforserousnonneovascularretinalpigmentepithelialdetachment AT araiy halfdosephotodynamictherapyforserousnonneovascularretinalpigmentepithelialdetachment AT kawashimah halfdosephotodynamictherapyforserousnonneovascularretinalpigmentepithelialdetachment AT yanagiy halfdosephotodynamictherapyforserousnonneovascularretinalpigmentepithelialdetachment
_version_	1718401921108148224

Half-dose photodynamic therapy for serous non-neovascular retinal pigment epithelial detachment

Ejemplares similares