RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis

Mutations in mitochondrially-encoded tRNA genes can lead to mitochondrial disorders. Here the authors use next generation RNA sequencing to reveal the role of a N1 -methyladenosine modification in tRNALys MERR patients for translation elongation and the stability of selected nascent chains.

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Autores principales:	Uwe Richter, Molly E. Evans, Wesley C. Clark, Paula Marttinen, Eric A. Shoubridge, Anu Suomalainen, Anna Wredenberg, Anna Wedell, Tao Pan, Brendan J. Battersby
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6476c28b9ae34dcfb308b5409a438859
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spelling	oai:doaj.org-article:6476c28b9ae34dcfb308b5409a4388592021-12-02T17:32:30ZRNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis10.1038/s41467-018-06471-z2041-1723https://doaj.org/article/6476c28b9ae34dcfb308b5409a4388592018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06471-zhttps://doaj.org/toc/2041-1723Mutations in mitochondrially-encoded tRNA genes can lead to mitochondrial disorders. Here the authors use next generation RNA sequencing to reveal the role of a N1 -methyladenosine modification in tRNALys MERR patients for translation elongation and the stability of selected nascent chains.Uwe RichterMolly E. EvansWesley C. ClarkPaula MarttinenEric A. ShoubridgeAnu SuomalainenAnna WredenbergAnna WedellTao PanBrendan J. BattersbyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Uwe Richter Molly E. Evans Wesley C. Clark Paula Marttinen Eric A. Shoubridge Anu Suomalainen Anna Wredenberg Anna Wedell Tao Pan Brendan J. Battersby RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis
description	Mutations in mitochondrially-encoded tRNA genes can lead to mitochondrial disorders. Here the authors use next generation RNA sequencing to reveal the role of a N1 -methyladenosine modification in tRNALys MERR patients for translation elongation and the stability of selected nascent chains.
format	article
author	Uwe Richter Molly E. Evans Wesley C. Clark Paula Marttinen Eric A. Shoubridge Anu Suomalainen Anna Wredenberg Anna Wedell Tao Pan Brendan J. Battersby
author_facet	Uwe Richter Molly E. Evans Wesley C. Clark Paula Marttinen Eric A. Shoubridge Anu Suomalainen Anna Wredenberg Anna Wedell Tao Pan Brendan J. Battersby
author_sort	Uwe Richter
title	RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis
title_short	RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis
title_full	RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis
title_fullStr	RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis
title_full_unstemmed	RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis
title_sort	rna modification landscape of the human mitochondrial trnalys regulates protein synthesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6476c28b9ae34dcfb308b5409a438859
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RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis

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