Immunoglobulin E levels and pregnancy-induced hypertension: Japan Environment and Children’s Study
Abstract High serum immunoglobulin E (IgE) levels are associated with cardiovascular events. We aimed to evaluate the association between total IgE levels during the first trimester of pregnancy and pregnancy-induced hypertension (PIH) development in a large Japanese cohort. We analysed data pertain...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/647c076f6a904d83b96058143e2f5a7c |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:647c076f6a904d83b96058143e2f5a7c |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:647c076f6a904d83b96058143e2f5a7c2021-12-02T17:32:59ZImmunoglobulin E levels and pregnancy-induced hypertension: Japan Environment and Children’s Study10.1038/s41598-021-88227-22045-2322https://doaj.org/article/647c076f6a904d83b96058143e2f5a7c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88227-2https://doaj.org/toc/2045-2322Abstract High serum immunoglobulin E (IgE) levels are associated with cardiovascular events. We aimed to evaluate the association between total IgE levels during the first trimester of pregnancy and pregnancy-induced hypertension (PIH) development in a large Japanese cohort. We analysed data pertaining to singleton primipara pregnancies recorded in the Japan Environment and Children’s Study involving births from 2011 to 2014. Serum IgE levels were determined using the immunonephelometric technique. High serum IgE was defined as level ≥ 170 IU/ml. Hypertensive disorders in pregnancy (HDP) were categorized into early onset (Eo) PIH (developed < 34 weeks) or late onset (Lo) PIH (developed ≧ 34 weeks). A multiple logistic regression model was used to estimate the risk of high serum IgE levels on PIH, Eo-PIH, and Lo-PIH. Overall, 32,518 participants were enrolled. The prevalence of total, Eo-, and Lo-PIH was 3.2%, 0.6%, and 2.3%, respectively. Patients with high serum IgE levels had an increased risk of Lo-HDP (adjusted odds ratio [aOR]:1.19, 95% confidence interval 1.01–1.40). No correlation was found with either PIH (total) or Eo-PIH. High serum IgE levels during the first trimester were associated with the risk of Lo-PIH. Our results could influence and shape further research regarding the pathogenesis of Lo hypertension.Hyo KyozukaTsuyoshi MurataToma FukudaYuta EndoAkiko YamaguchiShun YasudaAya KannoAkiko SatoYuka OgataMitsuaki HosoyaSeiji YasumuraKoichi HashimotoHidekazu NishigoriKeiya FujimoriThe Japan Environment and Children’s Study (JECS) GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Hyo Kyozuka Tsuyoshi Murata Toma Fukuda Yuta Endo Akiko Yamaguchi Shun Yasuda Aya Kanno Akiko Sato Yuka Ogata Mitsuaki Hosoya Seiji Yasumura Koichi Hashimoto Hidekazu Nishigori Keiya Fujimori The Japan Environment and Children’s Study (JECS) Group Immunoglobulin E levels and pregnancy-induced hypertension: Japan Environment and Children’s Study |
| description |
Abstract High serum immunoglobulin E (IgE) levels are associated with cardiovascular events. We aimed to evaluate the association between total IgE levels during the first trimester of pregnancy and pregnancy-induced hypertension (PIH) development in a large Japanese cohort. We analysed data pertaining to singleton primipara pregnancies recorded in the Japan Environment and Children’s Study involving births from 2011 to 2014. Serum IgE levels were determined using the immunonephelometric technique. High serum IgE was defined as level ≥ 170 IU/ml. Hypertensive disorders in pregnancy (HDP) were categorized into early onset (Eo) PIH (developed < 34 weeks) or late onset (Lo) PIH (developed ≧ 34 weeks). A multiple logistic regression model was used to estimate the risk of high serum IgE levels on PIH, Eo-PIH, and Lo-PIH. Overall, 32,518 participants were enrolled. The prevalence of total, Eo-, and Lo-PIH was 3.2%, 0.6%, and 2.3%, respectively. Patients with high serum IgE levels had an increased risk of Lo-HDP (adjusted odds ratio [aOR]:1.19, 95% confidence interval 1.01–1.40). No correlation was found with either PIH (total) or Eo-PIH. High serum IgE levels during the first trimester were associated with the risk of Lo-PIH. Our results could influence and shape further research regarding the pathogenesis of Lo hypertension. |
| format |
article |
| author |
Hyo Kyozuka Tsuyoshi Murata Toma Fukuda Yuta Endo Akiko Yamaguchi Shun Yasuda Aya Kanno Akiko Sato Yuka Ogata Mitsuaki Hosoya Seiji Yasumura Koichi Hashimoto Hidekazu Nishigori Keiya Fujimori The Japan Environment and Children’s Study (JECS) Group |
| author_facet |
Hyo Kyozuka Tsuyoshi Murata Toma Fukuda Yuta Endo Akiko Yamaguchi Shun Yasuda Aya Kanno Akiko Sato Yuka Ogata Mitsuaki Hosoya Seiji Yasumura Koichi Hashimoto Hidekazu Nishigori Keiya Fujimori The Japan Environment and Children’s Study (JECS) Group |
| author_sort |
Hyo Kyozuka |
| title |
Immunoglobulin E levels and pregnancy-induced hypertension: Japan Environment and Children’s Study |
| title_short |
Immunoglobulin E levels and pregnancy-induced hypertension: Japan Environment and Children’s Study |
| title_full |
Immunoglobulin E levels and pregnancy-induced hypertension: Japan Environment and Children’s Study |
| title_fullStr |
Immunoglobulin E levels and pregnancy-induced hypertension: Japan Environment and Children’s Study |
| title_full_unstemmed |
Immunoglobulin E levels and pregnancy-induced hypertension: Japan Environment and Children’s Study |
| title_sort |
immunoglobulin e levels and pregnancy-induced hypertension: japan environment and children’s study |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/647c076f6a904d83b96058143e2f5a7c |
| work_keys_str_mv |
AT hyokyozuka immunoglobulinelevelsandpregnancyinducedhypertensionjapanenvironmentandchildrensstudy AT tsuyoshimurata immunoglobulinelevelsandpregnancyinducedhypertensionjapanenvironmentandchildrensstudy AT tomafukuda immunoglobulinelevelsandpregnancyinducedhypertensionjapanenvironmentandchildrensstudy AT yutaendo immunoglobulinelevelsandpregnancyinducedhypertensionjapanenvironmentandchildrensstudy AT akikoyamaguchi immunoglobulinelevelsandpregnancyinducedhypertensionjapanenvironmentandchildrensstudy AT shunyasuda immunoglobulinelevelsandpregnancyinducedhypertensionjapanenvironmentandchildrensstudy AT ayakanno immunoglobulinelevelsandpregnancyinducedhypertensionjapanenvironmentandchildrensstudy AT akikosato immunoglobulinelevelsandpregnancyinducedhypertensionjapanenvironmentandchildrensstudy AT yukaogata immunoglobulinelevelsandpregnancyinducedhypertensionjapanenvironmentandchildrensstudy AT mitsuakihosoya immunoglobulinelevelsandpregnancyinducedhypertensionjapanenvironmentandchildrensstudy AT seijiyasumura immunoglobulinelevelsandpregnancyinducedhypertensionjapanenvironmentandchildrensstudy AT koichihashimoto immunoglobulinelevelsandpregnancyinducedhypertensionjapanenvironmentandchildrensstudy AT hidekazunishigori immunoglobulinelevelsandpregnancyinducedhypertensionjapanenvironmentandchildrensstudy AT keiyafujimori immunoglobulinelevelsandpregnancyinducedhypertensionjapanenvironmentandchildrensstudy AT thejapanenvironmentandchildrensstudyjecsgroup immunoglobulinelevelsandpregnancyinducedhypertensionjapanenvironmentandchildrensstudy |
| _version_ |
1718380123366883328 |