Quantitative optical nanophysiology of Ca2+ signaling at inner hair cell active zones

Quantitatively studying components of the presynapse requires high resolution optical methods. Here the authors use confocal microscopy as well as 2D- and 3D-STED nanoscopy to quantify the number and activity of active zone Ca2+ channels in inner hair cells.

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Autores principales:	Jakob Neef, Nicolai T. Urban, Tzu-Lun Ohn, Thomas Frank, Philippe Jean, Stefan W. Hell, Katrin I. Willig, Tobias Moser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/647c2305adf44fea980f8a6439f03222
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spelling	oai:doaj.org-article:647c2305adf44fea980f8a6439f032222021-12-02T15:34:05ZQuantitative optical nanophysiology of Ca2+ signaling at inner hair cell active zones10.1038/s41467-017-02612-y2041-1723https://doaj.org/article/647c2305adf44fea980f8a6439f032222018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02612-yhttps://doaj.org/toc/2041-1723Quantitatively studying components of the presynapse requires high resolution optical methods. Here the authors use confocal microscopy as well as 2D- and 3D-STED nanoscopy to quantify the number and activity of active zone Ca2+ channels in inner hair cells.Jakob NeefNicolai T. UrbanTzu-Lun OhnThomas FrankPhilippe JeanStefan W. HellKatrin I. WilligTobias MoserNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jakob Neef Nicolai T. Urban Tzu-Lun Ohn Thomas Frank Philippe Jean Stefan W. Hell Katrin I. Willig Tobias Moser Quantitative optical nanophysiology of Ca2+ signaling at inner hair cell active zones
description	Quantitatively studying components of the presynapse requires high resolution optical methods. Here the authors use confocal microscopy as well as 2D- and 3D-STED nanoscopy to quantify the number and activity of active zone Ca2+ channels in inner hair cells.
format	article
author	Jakob Neef Nicolai T. Urban Tzu-Lun Ohn Thomas Frank Philippe Jean Stefan W. Hell Katrin I. Willig Tobias Moser
author_facet	Jakob Neef Nicolai T. Urban Tzu-Lun Ohn Thomas Frank Philippe Jean Stefan W. Hell Katrin I. Willig Tobias Moser
author_sort	Jakob Neef
title	Quantitative optical nanophysiology of Ca2+ signaling at inner hair cell active zones
title_short	Quantitative optical nanophysiology of Ca2+ signaling at inner hair cell active zones
title_full	Quantitative optical nanophysiology of Ca2+ signaling at inner hair cell active zones
title_fullStr	Quantitative optical nanophysiology of Ca2+ signaling at inner hair cell active zones
title_full_unstemmed	Quantitative optical nanophysiology of Ca2+ signaling at inner hair cell active zones
title_sort	quantitative optical nanophysiology of ca2+ signaling at inner hair cell active zones
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/647c2305adf44fea980f8a6439f03222
work_keys_str_mv	AT jakobneef quantitativeopticalnanophysiologyofca2signalingatinnerhaircellactivezones AT nicolaiturban quantitativeopticalnanophysiologyofca2signalingatinnerhaircellactivezones AT tzulunohn quantitativeopticalnanophysiologyofca2signalingatinnerhaircellactivezones AT thomasfrank quantitativeopticalnanophysiologyofca2signalingatinnerhaircellactivezones AT philippejean quantitativeopticalnanophysiologyofca2signalingatinnerhaircellactivezones AT stefanwhell quantitativeopticalnanophysiologyofca2signalingatinnerhaircellactivezones AT katriniwillig quantitativeopticalnanophysiologyofca2signalingatinnerhaircellactivezones AT tobiasmoser quantitativeopticalnanophysiologyofca2signalingatinnerhaircellactivezones
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Quantitative optical nanophysiology of Ca2+ signaling at inner hair cell active zones

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