RNA G-quadruplex is resolved by repetitive and ATP-dependent mechanism of DHX36

DHX36 is a G-quadruplex (G4) resolving helicase that targets both DNA-G4 and RNA-G4. Here the authors use single molecule FRET measurements and show that DHX36 resolves RNA-G4 structures by a mechanism involving an ATP-dependent, highly repetitive and stepwise refolding of RNA-G4 that differs from i...

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Autores principales:	Ramreddy Tippana, Michael C. Chen, Natalia A. Demeshkina, Adrian R. Ferré-D’Amaré, Sua Myong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/647ccd90166c47d89791e381e1f5cdef
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id	oai:doaj.org-article:647ccd90166c47d89791e381e1f5cdef
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spelling	oai:doaj.org-article:647ccd90166c47d89791e381e1f5cdef2021-12-02T14:38:58ZRNA G-quadruplex is resolved by repetitive and ATP-dependent mechanism of DHX3610.1038/s41467-019-09802-w2041-1723https://doaj.org/article/647ccd90166c47d89791e381e1f5cdef2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09802-whttps://doaj.org/toc/2041-1723DHX36 is a G-quadruplex (G4) resolving helicase that targets both DNA-G4 and RNA-G4. Here the authors use single molecule FRET measurements and show that DHX36 resolves RNA-G4 structures by a mechanism involving an ATP-dependent, highly repetitive and stepwise refolding of RNA-G4 that differs from its DNA-G4 structures resolving mechanism.Ramreddy TippanaMichael C. ChenNatalia A. DemeshkinaAdrian R. Ferré-D’AmaréSua MyongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ramreddy Tippana Michael C. Chen Natalia A. Demeshkina Adrian R. Ferré-D’Amaré Sua Myong RNA G-quadruplex is resolved by repetitive and ATP-dependent mechanism of DHX36
description	DHX36 is a G-quadruplex (G4) resolving helicase that targets both DNA-G4 and RNA-G4. Here the authors use single molecule FRET measurements and show that DHX36 resolves RNA-G4 structures by a mechanism involving an ATP-dependent, highly repetitive and stepwise refolding of RNA-G4 that differs from its DNA-G4 structures resolving mechanism.
format	article
author	Ramreddy Tippana Michael C. Chen Natalia A. Demeshkina Adrian R. Ferré-D’Amaré Sua Myong
author_facet	Ramreddy Tippana Michael C. Chen Natalia A. Demeshkina Adrian R. Ferré-D’Amaré Sua Myong
author_sort	Ramreddy Tippana
title	RNA G-quadruplex is resolved by repetitive and ATP-dependent mechanism of DHX36
title_short	RNA G-quadruplex is resolved by repetitive and ATP-dependent mechanism of DHX36
title_full	RNA G-quadruplex is resolved by repetitive and ATP-dependent mechanism of DHX36
title_fullStr	RNA G-quadruplex is resolved by repetitive and ATP-dependent mechanism of DHX36
title_full_unstemmed	RNA G-quadruplex is resolved by repetitive and ATP-dependent mechanism of DHX36
title_sort	rna g-quadruplex is resolved by repetitive and atp-dependent mechanism of dhx36
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/647ccd90166c47d89791e381e1f5cdef
work_keys_str_mv	AT ramreddytippana rnagquadruplexisresolvedbyrepetitiveandatpdependentmechanismofdhx36 AT michaelcchen rnagquadruplexisresolvedbyrepetitiveandatpdependentmechanismofdhx36 AT nataliaademeshkina rnagquadruplexisresolvedbyrepetitiveandatpdependentmechanismofdhx36 AT adrianrferredamare rnagquadruplexisresolvedbyrepetitiveandatpdependentmechanismofdhx36 AT suamyong rnagquadruplexisresolvedbyrepetitiveandatpdependentmechanismofdhx36
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RNA G-quadruplex is resolved by repetitive and ATP-dependent mechanism of DHX36

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