Two new luminescent coordination polymers: Therapeutic effects on angina pectoris

Via tuning the central metal ions from Zn(II) to Cd(II), two new coordination polymers was acquired in success, namely {(H3O)[Zn4(bptc)3(3-bpmh)]}n·6n(H2O) (1) and [Cd3(bptc)(3-bpmh)(H2O)3]n·4n(H2O) (2) (H3bptc = biphenyl-3,4′,5-tricarboxylic acid, 3-bpmh = N,N-bis-pyridin-3-ylmethylene-hydrazine),...

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Autores principales: Jing Li, Jing-Wei Yuan, Hai-Bo Yu, Yu-Ming Kang, Qing-Feng Su
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Publicado: Elsevier 2022
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spelling oai:doaj.org-article:647e5265c05f48f3b952dde826574b8c2021-12-02T05:00:20ZTwo new luminescent coordination polymers: Therapeutic effects on angina pectoris1878-535210.1016/j.arabjc.2021.103566https://doaj.org/article/647e5265c05f48f3b952dde826574b8c2022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1878535221005815https://doaj.org/toc/1878-5352Via tuning the central metal ions from Zn(II) to Cd(II), two new coordination polymers was acquired in success, namely {(H3O)[Zn4(bptc)3(3-bpmh)]}n·6n(H2O) (1) and [Cd3(bptc)(3-bpmh)(H2O)3]n·4n(H2O) (2) (H3bptc = biphenyl-3,4′,5-tricarboxylic acid, 3-bpmh = N,N-bis-pyridin-3-ylmethylene-hydrazine), under hydrothermal conditions. The luminescent properties investigations showed that 1–2 emit intense luminescence with different maximum emission peaks. Their therapeutic and nursing protective effects on angina pectoris were assessed and we also discussed the corresponding mechanism simultaneously. The content of Interleukin-6 (IL-6) and soluble vascular cell adhesive molecule (SVCAM-1) released by endothelial cells (EC) was discovered through enzyme linked immunosorbent assay (ELISA) detection kit. Besides, the activation of Notch signaling pathway was also evaluated by the real time reverse transcription-polymerase chain reaction (RT-PCR). Influence of compounds on the peripheral blood white blood cell (WBC) numbers was measured with flow cytometry. We utilized optical coherence tomography (OCT) to measure the thickness of the fibrous cap of atherosclerotic plaque in patients with angina pectoris.Jing LiJing-Wei YuanHai-Bo YuYu-Ming KangQing-Feng SuElsevierarticleHydrothermal sysnthesisLuminescenceAngina pectorisEndothelial cellsChemistryQD1-999ENArabian Journal of Chemistry, Vol 15, Iss 2, Pp 103566- (2022)
institution DOAJ
collection DOAJ
language EN
topic Hydrothermal sysnthesis
Luminescence
Angina pectoris
Endothelial cells
Chemistry
QD1-999
spellingShingle Hydrothermal sysnthesis
Luminescence
Angina pectoris
Endothelial cells
Chemistry
QD1-999
Jing Li
Jing-Wei Yuan
Hai-Bo Yu
Yu-Ming Kang
Qing-Feng Su
Two new luminescent coordination polymers: Therapeutic effects on angina pectoris
description Via tuning the central metal ions from Zn(II) to Cd(II), two new coordination polymers was acquired in success, namely {(H3O)[Zn4(bptc)3(3-bpmh)]}n·6n(H2O) (1) and [Cd3(bptc)(3-bpmh)(H2O)3]n·4n(H2O) (2) (H3bptc = biphenyl-3,4′,5-tricarboxylic acid, 3-bpmh = N,N-bis-pyridin-3-ylmethylene-hydrazine), under hydrothermal conditions. The luminescent properties investigations showed that 1–2 emit intense luminescence with different maximum emission peaks. Their therapeutic and nursing protective effects on angina pectoris were assessed and we also discussed the corresponding mechanism simultaneously. The content of Interleukin-6 (IL-6) and soluble vascular cell adhesive molecule (SVCAM-1) released by endothelial cells (EC) was discovered through enzyme linked immunosorbent assay (ELISA) detection kit. Besides, the activation of Notch signaling pathway was also evaluated by the real time reverse transcription-polymerase chain reaction (RT-PCR). Influence of compounds on the peripheral blood white blood cell (WBC) numbers was measured with flow cytometry. We utilized optical coherence tomography (OCT) to measure the thickness of the fibrous cap of atherosclerotic plaque in patients with angina pectoris.
format article
author Jing Li
Jing-Wei Yuan
Hai-Bo Yu
Yu-Ming Kang
Qing-Feng Su
author_facet Jing Li
Jing-Wei Yuan
Hai-Bo Yu
Yu-Ming Kang
Qing-Feng Su
author_sort Jing Li
title Two new luminescent coordination polymers: Therapeutic effects on angina pectoris
title_short Two new luminescent coordination polymers: Therapeutic effects on angina pectoris
title_full Two new luminescent coordination polymers: Therapeutic effects on angina pectoris
title_fullStr Two new luminescent coordination polymers: Therapeutic effects on angina pectoris
title_full_unstemmed Two new luminescent coordination polymers: Therapeutic effects on angina pectoris
title_sort two new luminescent coordination polymers: therapeutic effects on angina pectoris
publisher Elsevier
publishDate 2022
url https://doaj.org/article/647e5265c05f48f3b952dde826574b8c
work_keys_str_mv AT jingli twonewluminescentcoordinationpolymerstherapeuticeffectsonanginapectoris
AT jingweiyuan twonewluminescentcoordinationpolymerstherapeuticeffectsonanginapectoris
AT haiboyu twonewluminescentcoordinationpolymerstherapeuticeffectsonanginapectoris
AT yumingkang twonewluminescentcoordinationpolymerstherapeuticeffectsonanginapectoris
AT qingfengsu twonewluminescentcoordinationpolymerstherapeuticeffectsonanginapectoris
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