Mesothelial-to-Mesenchymal Transition and Exosomes in Peritoneal Metastasis of Ovarian Cancer

Most patients with ovarian cancer (OvCA) present peritoneal disseminated disease at the time of diagnosis. During peritoneal metastasis, cancer cells detach from the primary tumor and disseminate through the intraperitoneal fluid. The peritoneal mesothelial cell (PMC) monolayer that lines the abdomi...

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Autores principales:	Lucía Pascual-Antón, Beatriz Cardeñes, Ricardo Sainz de la Cuesta, Lucía González-Cortijo, Manuel López-Cabrera, Carlos Cabañas, Pilar Sandoval
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ovarian cancer peritoneal metastasis mesothelial-to-mesenchymal transition exosomes Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/647ff9c3c2044dd7963ad428ee0e30aa
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spelling	oai:doaj.org-article:647ff9c3c2044dd7963ad428ee0e30aa2021-11-11T16:57:36ZMesothelial-to-Mesenchymal Transition and Exosomes in Peritoneal Metastasis of Ovarian Cancer10.3390/ijms2221114961422-00671661-6596https://doaj.org/article/647ff9c3c2044dd7963ad428ee0e30aa2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11496https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Most patients with ovarian cancer (OvCA) present peritoneal disseminated disease at the time of diagnosis. During peritoneal metastasis, cancer cells detach from the primary tumor and disseminate through the intraperitoneal fluid. The peritoneal mesothelial cell (PMC) monolayer that lines the abdominal cavity is the first barrier encountered by OvCA cells. Subsequent progression of tumors through the peritoneum leads to the accumulation into the peritoneal stroma of a sizeable population of carcinoma-associated fibroblasts (CAFs), which is mainly originated from a mesothelial-to-mesenchymal transition (MMT) process. A common characteristic of OvCA patients is the intraperitoneal accumulation of ascitic fluid, which is composed of cytokines, chemokines, growth factors, miRNAs, and proteins contained in exosomes, as well as tumor and mesothelial suspended cells, among other components that vary in proportion between patients. Exosomes are small extracellular vesicles that have been shown to mediate peritoneal metastasis by educating a pre-metastatic niche, promoting the accumulation of CAFs via MMT, and inducing tumor growth and chemoresistance. This review summarizes and discusses the pivotal role of exosomes and MMT as mediators of OvCA peritoneal colonization and as emerging diagnostic and therapeutic targets.Lucía Pascual-AntónBeatriz CardeñesRicardo Sainz de la CuestaLucía González-CortijoManuel López-CabreraCarlos CabañasPilar SandovalMDPI AGarticleovarian cancerperitoneal metastasismesothelial-to-mesenchymal transitionexosomesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11496, p 11496 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ovarian cancer peritoneal metastasis mesothelial-to-mesenchymal transition exosomes Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	ovarian cancer peritoneal metastasis mesothelial-to-mesenchymal transition exosomes Biology (General) QH301-705.5 Chemistry QD1-999 Lucía Pascual-Antón Beatriz Cardeñes Ricardo Sainz de la Cuesta Lucía González-Cortijo Manuel López-Cabrera Carlos Cabañas Pilar Sandoval Mesothelial-to-Mesenchymal Transition and Exosomes in Peritoneal Metastasis of Ovarian Cancer
description	Most patients with ovarian cancer (OvCA) present peritoneal disseminated disease at the time of diagnosis. During peritoneal metastasis, cancer cells detach from the primary tumor and disseminate through the intraperitoneal fluid. The peritoneal mesothelial cell (PMC) monolayer that lines the abdominal cavity is the first barrier encountered by OvCA cells. Subsequent progression of tumors through the peritoneum leads to the accumulation into the peritoneal stroma of a sizeable population of carcinoma-associated fibroblasts (CAFs), which is mainly originated from a mesothelial-to-mesenchymal transition (MMT) process. A common characteristic of OvCA patients is the intraperitoneal accumulation of ascitic fluid, which is composed of cytokines, chemokines, growth factors, miRNAs, and proteins contained in exosomes, as well as tumor and mesothelial suspended cells, among other components that vary in proportion between patients. Exosomes are small extracellular vesicles that have been shown to mediate peritoneal metastasis by educating a pre-metastatic niche, promoting the accumulation of CAFs via MMT, and inducing tumor growth and chemoresistance. This review summarizes and discusses the pivotal role of exosomes and MMT as mediators of OvCA peritoneal colonization and as emerging diagnostic and therapeutic targets.
format	article
author	Lucía Pascual-Antón Beatriz Cardeñes Ricardo Sainz de la Cuesta Lucía González-Cortijo Manuel López-Cabrera Carlos Cabañas Pilar Sandoval
author_facet	Lucía Pascual-Antón Beatriz Cardeñes Ricardo Sainz de la Cuesta Lucía González-Cortijo Manuel López-Cabrera Carlos Cabañas Pilar Sandoval
author_sort	Lucía Pascual-Antón
title	Mesothelial-to-Mesenchymal Transition and Exosomes in Peritoneal Metastasis of Ovarian Cancer
title_short	Mesothelial-to-Mesenchymal Transition and Exosomes in Peritoneal Metastasis of Ovarian Cancer
title_full	Mesothelial-to-Mesenchymal Transition and Exosomes in Peritoneal Metastasis of Ovarian Cancer
title_fullStr	Mesothelial-to-Mesenchymal Transition and Exosomes in Peritoneal Metastasis of Ovarian Cancer
title_full_unstemmed	Mesothelial-to-Mesenchymal Transition and Exosomes in Peritoneal Metastasis of Ovarian Cancer
title_sort	mesothelial-to-mesenchymal transition and exosomes in peritoneal metastasis of ovarian cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/647ff9c3c2044dd7963ad428ee0e30aa
work_keys_str_mv	AT luciapascualanton mesothelialtomesenchymaltransitionandexosomesinperitonealmetastasisofovariancancer AT beatrizcardenes mesothelialtomesenchymaltransitionandexosomesinperitonealmetastasisofovariancancer AT ricardosainzdelacuesta mesothelialtomesenchymaltransitionandexosomesinperitonealmetastasisofovariancancer AT luciagonzalezcortijo mesothelialtomesenchymaltransitionandexosomesinperitonealmetastasisofovariancancer AT manuellopezcabrera mesothelialtomesenchymaltransitionandexosomesinperitonealmetastasisofovariancancer AT carloscabanas mesothelialtomesenchymaltransitionandexosomesinperitonealmetastasisofovariancancer AT pilarsandoval mesothelialtomesenchymaltransitionandexosomesinperitonealmetastasisofovariancancer
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Mesothelial-to-Mesenchymal Transition and Exosomes in Peritoneal Metastasis of Ovarian Cancer

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