Exploitation of blood non-Newtonian properties for ultrasonic measurement of hematocrit

Abstract New processing techniques for manipulating blood and its components at a microfluidic scale are currently implemented. As for extracorporeal circulation, the in-line evaluation and monitoring of blood properties during these microfluidic techniques is a challenging task. Here, we show that...

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Autores principales:	B. Pialot, J. Gachelin, J. Provost, O. Couture
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/64825d0cc67f4519b246ad8dd98ffe43
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spelling	oai:doaj.org-article:64825d0cc67f4519b246ad8dd98ffe432021-12-02T15:54:45ZExploitation of blood non-Newtonian properties for ultrasonic measurement of hematocrit10.1038/s41598-021-89704-42045-2322https://doaj.org/article/64825d0cc67f4519b246ad8dd98ffe432021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89704-4https://doaj.org/toc/2045-2322Abstract New processing techniques for manipulating blood and its components at a microfluidic scale are currently implemented. As for extracorporeal circulation, the in-line evaluation and monitoring of blood properties during these microfluidic techniques is a challenging task. Here, we show that the blood hematocrit can be measured non-invasively in a sub-millimeter medical tube using the non-Newtonian behavior of blood velocity profile. This hematocrit measurement is demonstrated on human blood with a simple Doppler ultrasound system. Results show a mean measurement error of 4.6 ± 1.3%Hct for hematocrit up to 52% and for 5 s-long ultrasonic signals. The simplicity and the measurement scale of the approach make it highly valuable for measuring hematocrit in new blood separation techniques. The approach may have an impact on in-vitro blood processing in general.B. PialotJ. GachelinJ. ProvostO. CoutureNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q B. Pialot J. Gachelin J. Provost O. Couture Exploitation of blood non-Newtonian properties for ultrasonic measurement of hematocrit
description	Abstract New processing techniques for manipulating blood and its components at a microfluidic scale are currently implemented. As for extracorporeal circulation, the in-line evaluation and monitoring of blood properties during these microfluidic techniques is a challenging task. Here, we show that the blood hematocrit can be measured non-invasively in a sub-millimeter medical tube using the non-Newtonian behavior of blood velocity profile. This hematocrit measurement is demonstrated on human blood with a simple Doppler ultrasound system. Results show a mean measurement error of 4.6 ± 1.3%Hct for hematocrit up to 52% and for 5 s-long ultrasonic signals. The simplicity and the measurement scale of the approach make it highly valuable for measuring hematocrit in new blood separation techniques. The approach may have an impact on in-vitro blood processing in general.
format	article
author	B. Pialot J. Gachelin J. Provost O. Couture
author_facet	B. Pialot J. Gachelin J. Provost O. Couture
author_sort	B. Pialot
title	Exploitation of blood non-Newtonian properties for ultrasonic measurement of hematocrit
title_short	Exploitation of blood non-Newtonian properties for ultrasonic measurement of hematocrit
title_full	Exploitation of blood non-Newtonian properties for ultrasonic measurement of hematocrit
title_fullStr	Exploitation of blood non-Newtonian properties for ultrasonic measurement of hematocrit
title_full_unstemmed	Exploitation of blood non-Newtonian properties for ultrasonic measurement of hematocrit
title_sort	exploitation of blood non-newtonian properties for ultrasonic measurement of hematocrit
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/64825d0cc67f4519b246ad8dd98ffe43
work_keys_str_mv	AT bpialot exploitationofbloodnonnewtonianpropertiesforultrasonicmeasurementofhematocrit AT jgachelin exploitationofbloodnonnewtonianpropertiesforultrasonicmeasurementofhematocrit AT jprovost exploitationofbloodnonnewtonianpropertiesforultrasonicmeasurementofhematocrit AT ocouture exploitationofbloodnonnewtonianpropertiesforultrasonicmeasurementofhematocrit
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Exploitation of blood non-Newtonian properties for ultrasonic measurement of hematocrit

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