Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism

The clinical picture of primary hyperparathyroidism (PHPT) which caused by parathyroid neoplasms often includes metabolic syndrome leading to the development of cardiovascular diseases. According to clinical studies, an increased incidence of diabetes mellitus, insulin resistance, obesity, dyslipide...

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Autores principales:	Ekaterina E. Bibik, [Anna K. Eremkina, Julia A. Krupinova, Natalia V. Klementieva, Ekaterina A. Dobreva, Natalia G. Mokrysheva
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2021
Materias:	primary hyperparathyroidism, parathyroid hormone, hypercalcemia, diabetes mellitus, insulin resistance, obesity, dyslipidemia, hyperuricemia Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/648637706a8547879ee395ca19a207d6
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spelling	oai:doaj.org-article:648637706a8547879ee395ca19a207d62021-11-14T09:00:23ZImpaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism2072-03512072-037810.14341/DM12436https://doaj.org/article/648637706a8547879ee395ca19a207d62021-01-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/12436https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378The clinical picture of primary hyperparathyroidism (PHPT) which caused by parathyroid neoplasms often includes metabolic syndrome leading to the development of cardiovascular diseases. According to clinical studies, an increased incidence of diabetes mellitus, insulin resistance, obesity, dyslipidemia, hyperuricemia and other disorders that signifi tly affect the life span and quality are observed in patients with PHPT regardless of the form and the severity of the underlying disease. Basic research shows the potential nonclassical effects of high levels of parathyroid hormone and calcium on adipose tissue, pancreas, gastrointestinal tract and kidneys. However, the pathogenetic mechanisms of impaired carbohydrate and other types of metabolism in patients with parathyroid hyperfunction remain unclear because of the lack of relevant experimental models and the heterogeneity of patient groups. Besides, the effect of surgery on metabolic abnormalities is also controversial. Nowadays a deeper understanding of this issue is required, which can subsequently help in the creation of optimal approach to diagnosis and treatment of patients. This review covers different aspects of metabolic disorders in patients with PHPT, as well as potential key factors of their development.Ekaterina E. Bibik[Anna K. EremkinaJulia A. KrupinovaNatalia V. KlementievaEkaterina A. DobrevaNatalia G. MokryshevaEndocrinology Research Centrearticleprimary hyperparathyroidism, parathyroid hormone, hypercalcemia, diabetes mellitus, insulin resistance, obesity, dyslipidemia, hyperuricemiaNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 23, Iss 5, Pp 459-466 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	primary hyperparathyroidism, parathyroid hormone, hypercalcemia, diabetes mellitus, insulin resistance, obesity, dyslipidemia, hyperuricemia Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	primary hyperparathyroidism, parathyroid hormone, hypercalcemia, diabetes mellitus, insulin resistance, obesity, dyslipidemia, hyperuricemia Nutritional diseases. Deficiency diseases RC620-627 Ekaterina E. Bibik [Anna K. Eremkina Julia A. Krupinova Natalia V. Klementieva Ekaterina A. Dobreva Natalia G. Mokrysheva Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism
description	The clinical picture of primary hyperparathyroidism (PHPT) which caused by parathyroid neoplasms often includes metabolic syndrome leading to the development of cardiovascular diseases. According to clinical studies, an increased incidence of diabetes mellitus, insulin resistance, obesity, dyslipidemia, hyperuricemia and other disorders that signifi tly affect the life span and quality are observed in patients with PHPT regardless of the form and the severity of the underlying disease. Basic research shows the potential nonclassical effects of high levels of parathyroid hormone and calcium on adipose tissue, pancreas, gastrointestinal tract and kidneys. However, the pathogenetic mechanisms of impaired carbohydrate and other types of metabolism in patients with parathyroid hyperfunction remain unclear because of the lack of relevant experimental models and the heterogeneity of patient groups. Besides, the effect of surgery on metabolic abnormalities is also controversial. Nowadays a deeper understanding of this issue is required, which can subsequently help in the creation of optimal approach to diagnosis and treatment of patients. This review covers different aspects of metabolic disorders in patients with PHPT, as well as potential key factors of their development.
format	article
author	Ekaterina E. Bibik [Anna K. Eremkina Julia A. Krupinova Natalia V. Klementieva Ekaterina A. Dobreva Natalia G. Mokrysheva
author_facet	Ekaterina E. Bibik [Anna K. Eremkina Julia A. Krupinova Natalia V. Klementieva Ekaterina A. Dobreva Natalia G. Mokrysheva
author_sort	Ekaterina E. Bibik
title	Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism
title_short	Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism
title_full	Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism
title_fullStr	Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism
title_full_unstemmed	Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism
title_sort	impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism
publisher	Endocrinology Research Centre
publishDate	2021
url	https://doaj.org/article/648637706a8547879ee395ca19a207d6
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_version_	1718429466970030080

Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism

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