SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans.

SARS-CoV-2 infection in minks has become a serious problem, as the virus may mutate and reinfect humans; some countries have decided to cull minks. Here, the virus sequencing data in minks were analysed and compared to those of human-virus. Although the mink-virus maintained the characteristics of h...

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Autor principal:	Tomokazu Konishi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/648794ce154a4e07b59c34a13d74235d
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spelling	oai:doaj.org-article:648794ce154a4e07b59c34a13d74235d2021-12-02T20:18:55ZSARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans.1932-620310.1371/journal.pone.0247626https://doaj.org/article/648794ce154a4e07b59c34a13d74235d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0247626https://doaj.org/toc/1932-6203SARS-CoV-2 infection in minks has become a serious problem, as the virus may mutate and reinfect humans; some countries have decided to cull minks. Here, the virus sequencing data in minks were analysed and compared to those of human-virus. Although the mink-virus maintained the characteristics of human-virus, some variants rapidly mutated, adapting to minks. Some mink-derived variants infected humans, which accounted for 40% of the total SARS-CoV-2 cases in the Netherlands. These variants appear to be less lethal and infective compared to those in humans. Variants that have mutated further among minks were not found in humans. Such mink-viruses might be suitable for vaccination for humans, such as in the case of the smallpox virus, which is less infective and toxic to humans.Tomokazu KonishiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0247626 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomokazu Konishi SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans.
description	SARS-CoV-2 infection in minks has become a serious problem, as the virus may mutate and reinfect humans; some countries have decided to cull minks. Here, the virus sequencing data in minks were analysed and compared to those of human-virus. Although the mink-virus maintained the characteristics of human-virus, some variants rapidly mutated, adapting to minks. Some mink-derived variants infected humans, which accounted for 40% of the total SARS-CoV-2 cases in the Netherlands. These variants appear to be less lethal and infective compared to those in humans. Variants that have mutated further among minks were not found in humans. Such mink-viruses might be suitable for vaccination for humans, such as in the case of the smallpox virus, which is less infective and toxic to humans.
format	article
author	Tomokazu Konishi
author_facet	Tomokazu Konishi
author_sort	Tomokazu Konishi
title	SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans.
title_short	SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans.
title_full	SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans.
title_fullStr	SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans.
title_full_unstemmed	SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans.
title_sort	sars-cov-2 mutations among minks show reduced lethality and infectivity to humans.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/648794ce154a4e07b59c34a13d74235d
work_keys_str_mv	AT tomokazukonishi sarscov2mutationsamongminksshowreducedlethalityandinfectivitytohumans
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SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans.

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