Feasibility of utilizing ultra-low-dose contrast medium for pancreatic artery depiction using the combination of advanced virtual monoenergetic imaging and high-concentration contrast medium: an intra-patient study

Abstract Objectives The least amount of contrast medium (CM) should be used under the premise of adequate diagnosis. The purpose of this study is to evaluate the feasibility of utilizing ultra-low-dose (224 mgI/kg) CM for pancreatic artery depiction using the combination of advanced virtual monoener...

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Main Authors:	Juan Li, Yu-hong Wang, Fu-ling Zheng, Xin-yue Chen, Yun Lin, Cai-rong Zhu, Yi-fan Wu, Qiang Xu, Zheng-yu Jin, Hua-dan Xue
Format:	article
Language:	EN
Published:	SpringerOpen 2021
Subjects:	Computed tomography angiography Pancreas Arteries Contrast media Medical physics. Medical radiology. Nuclear medicine R895-920
Online Access:	https://doaj.org/article/648a2fe412b6476d8f2b2966730a8d96
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spelling	oai:doaj.org-article:648a2fe412b6476d8f2b2966730a8d962021-11-14T12:10:52ZFeasibility of utilizing ultra-low-dose contrast medium for pancreatic artery depiction using the combination of advanced virtual monoenergetic imaging and high-concentration contrast medium: an intra-patient study10.1186/s13244-021-01079-21869-4101https://doaj.org/article/648a2fe412b6476d8f2b2966730a8d962021-11-01T00:00:00Zhttps://doi.org/10.1186/s13244-021-01079-2https://doaj.org/toc/1869-4101Abstract Objectives The least amount of contrast medium (CM) should be used under the premise of adequate diagnosis. The purpose of this study is to evaluate the feasibility of utilizing ultra-low-dose (224 mgI/kg) CM for pancreatic artery depiction using the combination of advanced virtual monoenergetic imaging (VMI+) and high-concentration (400 mgI/mL) CM. Materials and methods 41 patients who underwent both normal dose CM (ND-CM, 320 mgI/kg) and low dose CM (LD-CM, 224 mgI/kg) thoracoabdominal enhanced CT for tumor follow-up were prospectively included. The VMI+ at the energy level of 40-kev for LD-CM images was reconstructed. CT attenuation, signal-to-noise ratios (SNRs), and contrast-to-noise ratios (CNRs) of the abdominal artery, celiac artery, and superior mesenteric artery (SMA) and qualitative scores of pancreatic arteries depiction were recorded and compared among the three groups (ND-CM, LD-CM, and VMI+ LD-CM images). ANOVA and Friedman tests were used for statistical analysis. Results All quantitative and qualitative parameters on LD-CM images were lower than that on ND-CM images (all p < 0.01). There were no significant differences of all arteries’ qualitative scores between ND-CM and VMI+ LD-CM images (all p > 0.05). VMI+ LD-CM images had the highest mean CT and CNR values of all arteries (all p < 0.0001). The CM volume was 52.6 ± 9.4 mL for the ND-CM group and 37.0 ± 6.7 mL for the LD-CM group. Conclusion Ultra-low-dose CM (224 mgI/kg) was feasible for depicting pancreatic arteries. Inferior angiographic image quality could be successfully compensated by VMI+ and high-concentration CM.Juan LiYu-hong WangFu-ling ZhengXin-yue ChenYun LinCai-rong ZhuYi-fan WuQiang XuZheng-yu JinHua-dan XueSpringerOpenarticleComputed tomography angiographyPancreasArteriesContrast mediaMedical physics. Medical radiology. Nuclear medicineR895-920ENInsights into Imaging, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Computed tomography angiography Pancreas Arteries Contrast media Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	Computed tomography angiography Pancreas Arteries Contrast media Medical physics. Medical radiology. Nuclear medicine R895-920 Juan Li Yu-hong Wang Fu-ling Zheng Xin-yue Chen Yun Lin Cai-rong Zhu Yi-fan Wu Qiang Xu Zheng-yu Jin Hua-dan Xue Feasibility of utilizing ultra-low-dose contrast medium for pancreatic artery depiction using the combination of advanced virtual monoenergetic imaging and high-concentration contrast medium: an intra-patient study
description	Abstract Objectives The least amount of contrast medium (CM) should be used under the premise of adequate diagnosis. The purpose of this study is to evaluate the feasibility of utilizing ultra-low-dose (224 mgI/kg) CM for pancreatic artery depiction using the combination of advanced virtual monoenergetic imaging (VMI+) and high-concentration (400 mgI/mL) CM. Materials and methods 41 patients who underwent both normal dose CM (ND-CM, 320 mgI/kg) and low dose CM (LD-CM, 224 mgI/kg) thoracoabdominal enhanced CT for tumor follow-up were prospectively included. The VMI+ at the energy level of 40-kev for LD-CM images was reconstructed. CT attenuation, signal-to-noise ratios (SNRs), and contrast-to-noise ratios (CNRs) of the abdominal artery, celiac artery, and superior mesenteric artery (SMA) and qualitative scores of pancreatic arteries depiction were recorded and compared among the three groups (ND-CM, LD-CM, and VMI+ LD-CM images). ANOVA and Friedman tests were used for statistical analysis. Results All quantitative and qualitative parameters on LD-CM images were lower than that on ND-CM images (all p < 0.01). There were no significant differences of all arteries’ qualitative scores between ND-CM and VMI+ LD-CM images (all p > 0.05). VMI+ LD-CM images had the highest mean CT and CNR values of all arteries (all p < 0.0001). The CM volume was 52.6 ± 9.4 mL for the ND-CM group and 37.0 ± 6.7 mL for the LD-CM group. Conclusion Ultra-low-dose CM (224 mgI/kg) was feasible for depicting pancreatic arteries. Inferior angiographic image quality could be successfully compensated by VMI+ and high-concentration CM.
format	article
author	Juan Li Yu-hong Wang Fu-ling Zheng Xin-yue Chen Yun Lin Cai-rong Zhu Yi-fan Wu Qiang Xu Zheng-yu Jin Hua-dan Xue
author_facet	Juan Li Yu-hong Wang Fu-ling Zheng Xin-yue Chen Yun Lin Cai-rong Zhu Yi-fan Wu Qiang Xu Zheng-yu Jin Hua-dan Xue
author_sort	Juan Li
title	Feasibility of utilizing ultra-low-dose contrast medium for pancreatic artery depiction using the combination of advanced virtual monoenergetic imaging and high-concentration contrast medium: an intra-patient study
title_short	Feasibility of utilizing ultra-low-dose contrast medium for pancreatic artery depiction using the combination of advanced virtual monoenergetic imaging and high-concentration contrast medium: an intra-patient study
title_full	Feasibility of utilizing ultra-low-dose contrast medium for pancreatic artery depiction using the combination of advanced virtual monoenergetic imaging and high-concentration contrast medium: an intra-patient study
title_fullStr	Feasibility of utilizing ultra-low-dose contrast medium for pancreatic artery depiction using the combination of advanced virtual monoenergetic imaging and high-concentration contrast medium: an intra-patient study
title_full_unstemmed	Feasibility of utilizing ultra-low-dose contrast medium for pancreatic artery depiction using the combination of advanced virtual monoenergetic imaging and high-concentration contrast medium: an intra-patient study
title_sort	feasibility of utilizing ultra-low-dose contrast medium for pancreatic artery depiction using the combination of advanced virtual monoenergetic imaging and high-concentration contrast medium: an intra-patient study
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/648a2fe412b6476d8f2b2966730a8d96
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Feasibility of utilizing ultra-low-dose contrast medium for pancreatic artery depiction using the combination of advanced virtual monoenergetic imaging and high-concentration contrast medium: an intra-patient study

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