Brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model

Abstract Mechanical ventilation is the cornerstone of the Intensive Care Unit. However, it has been associated with many negative consequences. Recently, ventilator-induced brain injury has been reported in rodents under injurious ventilation settings. Our group wanted to explore the extent of brain...

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Autores principales:	Thiago G. Bassi, Elizabeth C. Rohrs, Karl C. Fernandez, Marlena Ornowska, Michelle Nicholas, Matt Gani, Doug Evans, Steven C. Reynolds
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/648a6a24c0d54728b8a0e4a0eca8ddcb
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spelling	oai:doaj.org-article:648a6a24c0d54728b8a0e4a0eca8ddcb2021-12-02T13:33:45ZBrain injury after 50 h of lung-protective mechanical ventilation in a preclinical model10.1038/s41598-021-84440-12045-2322https://doaj.org/article/648a6a24c0d54728b8a0e4a0eca8ddcb2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84440-1https://doaj.org/toc/2045-2322Abstract Mechanical ventilation is the cornerstone of the Intensive Care Unit. However, it has been associated with many negative consequences. Recently, ventilator-induced brain injury has been reported in rodents under injurious ventilation settings. Our group wanted to explore the extent of brain injury after 50 h of mechanical ventilation, sedation and physical immobility, quantifying hippocampal apoptosis and inflammation, in a normal-lung porcine study. After 50 h of lung-protective mechanical ventilation, sedation and immobility, greater levels of hippocampal apoptosis and neuroinflammation were clearly observed in the mechanically ventilated group, in comparison to a never-ventilated group. Markers in the serum for astrocyte damage and neuronal damage were also higher in the mechanically ventilated group. Therefore, our study demonstrated that considerable hippocampal insult can be observed after 50 h of lung-protective mechanical ventilation, sedation and physical immobility.Thiago G. BassiElizabeth C. RohrsKarl C. FernandezMarlena OrnowskaMichelle NicholasMatt GaniDoug EvansSteven C. ReynoldsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thiago G. Bassi Elizabeth C. Rohrs Karl C. Fernandez Marlena Ornowska Michelle Nicholas Matt Gani Doug Evans Steven C. Reynolds Brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model
description	Abstract Mechanical ventilation is the cornerstone of the Intensive Care Unit. However, it has been associated with many negative consequences. Recently, ventilator-induced brain injury has been reported in rodents under injurious ventilation settings. Our group wanted to explore the extent of brain injury after 50 h of mechanical ventilation, sedation and physical immobility, quantifying hippocampal apoptosis and inflammation, in a normal-lung porcine study. After 50 h of lung-protective mechanical ventilation, sedation and immobility, greater levels of hippocampal apoptosis and neuroinflammation were clearly observed in the mechanically ventilated group, in comparison to a never-ventilated group. Markers in the serum for astrocyte damage and neuronal damage were also higher in the mechanically ventilated group. Therefore, our study demonstrated that considerable hippocampal insult can be observed after 50 h of lung-protective mechanical ventilation, sedation and physical immobility.
format	article
author	Thiago G. Bassi Elizabeth C. Rohrs Karl C. Fernandez Marlena Ornowska Michelle Nicholas Matt Gani Doug Evans Steven C. Reynolds
author_facet	Thiago G. Bassi Elizabeth C. Rohrs Karl C. Fernandez Marlena Ornowska Michelle Nicholas Matt Gani Doug Evans Steven C. Reynolds
author_sort	Thiago G. Bassi
title	Brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model
title_short	Brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model
title_full	Brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model
title_fullStr	Brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model
title_full_unstemmed	Brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model
title_sort	brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/648a6a24c0d54728b8a0e4a0eca8ddcb
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Brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model

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