Stretchable chiral pockets for palladium-catalyzed highly chemo- and enantioselective allenylation

Chiral pyrazolone derivatives show promising biological activity in commercial drugs. Here, the authors report an enantioselective allenylation of pyrazolones by fine tuning of Trost’s ligands, which leads to a chiral pocket featuring high efficiency and asymmetric induction in the catalytic process...

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Autores principales:	Yuchen Zhang, Xue Zhang, Shengming Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/648af6fd7be94fa98bd514ee85659f79
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spelling	oai:doaj.org-article:648af6fd7be94fa98bd514ee85659f792021-12-02T17:33:40ZStretchable chiral pockets for palladium-catalyzed highly chemo- and enantioselective allenylation10.1038/s41467-021-22498-12041-1723https://doaj.org/article/648af6fd7be94fa98bd514ee85659f792021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22498-1https://doaj.org/toc/2041-1723Chiral pyrazolone derivatives show promising biological activity in commercial drugs. Here, the authors report an enantioselective allenylation of pyrazolones by fine tuning of Trost’s ligands, which leads to a chiral pocket featuring high efficiency and asymmetric induction in the catalytic process.Yuchen ZhangXue ZhangShengming MaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuchen Zhang Xue Zhang Shengming Ma Stretchable chiral pockets for palladium-catalyzed highly chemo- and enantioselective allenylation
description	Chiral pyrazolone derivatives show promising biological activity in commercial drugs. Here, the authors report an enantioselective allenylation of pyrazolones by fine tuning of Trost’s ligands, which leads to a chiral pocket featuring high efficiency and asymmetric induction in the catalytic process.
format	article
author	Yuchen Zhang Xue Zhang Shengming Ma
author_facet	Yuchen Zhang Xue Zhang Shengming Ma
author_sort	Yuchen Zhang
title	Stretchable chiral pockets for palladium-catalyzed highly chemo- and enantioselective allenylation
title_short	Stretchable chiral pockets for palladium-catalyzed highly chemo- and enantioselective allenylation
title_full	Stretchable chiral pockets for palladium-catalyzed highly chemo- and enantioselective allenylation
title_fullStr	Stretchable chiral pockets for palladium-catalyzed highly chemo- and enantioselective allenylation
title_full_unstemmed	Stretchable chiral pockets for palladium-catalyzed highly chemo- and enantioselective allenylation
title_sort	stretchable chiral pockets for palladium-catalyzed highly chemo- and enantioselective allenylation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/648af6fd7be94fa98bd514ee85659f79
work_keys_str_mv	AT yuchenzhang stretchablechiralpocketsforpalladiumcatalyzedhighlychemoandenantioselectiveallenylation AT xuezhang stretchablechiralpocketsforpalladiumcatalyzedhighlychemoandenantioselectiveallenylation AT shengmingma stretchablechiralpocketsforpalladiumcatalyzedhighlychemoandenantioselectiveallenylation
_version_	1718379943697580032

Stretchable chiral pockets for palladium-catalyzed highly chemo- and enantioselective allenylation

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