Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination

The Legionella pneumophila effector MavC inhibits the human ubiquitin-conjugating enzyme Ube2N. Here, the authors combine NMR, X-ray crystallography and biochemical assays and show that MavC catalyses the intramolecular transglutaminase reaction between the Ube2N and Ub subunits of the Ube2N∼Ub conj...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kedar Puvar, Shalini Iyer, Jiaqi Fu, Sebastian Kenny, Kristos I. Negrón Terón, Zhao-Qing Luo, Peter S. Brzovic, Rachel E. Klevit, Chittaranjan Das
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/648e9d96e29748c9b52e0dbcb435943c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:648e9d96e29748c9b52e0dbcb435943c
record_format	dspace
spelling	oai:doaj.org-article:648e9d96e29748c9b52e0dbcb435943c2021-12-02T15:43:16ZLegionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination10.1038/s41467-020-16211-x2041-1723https://doaj.org/article/648e9d96e29748c9b52e0dbcb435943c2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16211-xhttps://doaj.org/toc/2041-1723The Legionella pneumophila effector MavC inhibits the human ubiquitin-conjugating enzyme Ube2N. Here, the authors combine NMR, X-ray crystallography and biochemical assays and show that MavC catalyses the intramolecular transglutaminase reaction between the Ube2N and Ub subunits of the Ube2N∼Ub conjugate and present the substrate- and product-bound MavC crystal structures.Kedar PuvarShalini IyerJiaqi FuSebastian KennyKristos I. Negrón TerónZhao-Qing LuoPeter S. BrzovicRachel E. KlevitChittaranjan DasNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kedar Puvar Shalini Iyer Jiaqi Fu Sebastian Kenny Kristos I. Negrón Terón Zhao-Qing Luo Peter S. Brzovic Rachel E. Klevit Chittaranjan Das Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination
description	The Legionella pneumophila effector MavC inhibits the human ubiquitin-conjugating enzyme Ube2N. Here, the authors combine NMR, X-ray crystallography and biochemical assays and show that MavC catalyses the intramolecular transglutaminase reaction between the Ube2N and Ub subunits of the Ube2N∼Ub conjugate and present the substrate- and product-bound MavC crystal structures.
format	article
author	Kedar Puvar Shalini Iyer Jiaqi Fu Sebastian Kenny Kristos I. Negrón Terón Zhao-Qing Luo Peter S. Brzovic Rachel E. Klevit Chittaranjan Das
author_facet	Kedar Puvar Shalini Iyer Jiaqi Fu Sebastian Kenny Kristos I. Negrón Terón Zhao-Qing Luo Peter S. Brzovic Rachel E. Klevit Chittaranjan Das
author_sort	Kedar Puvar
title	Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination
title_short	Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination
title_full	Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination
title_fullStr	Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination
title_full_unstemmed	Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination
title_sort	legionella effector mavc targets the ube2n~ub conjugate for noncanonical ubiquitination
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/648e9d96e29748c9b52e0dbcb435943c
work_keys_str_mv	AT kedarpuvar legionellaeffectormavctargetstheube2nubconjugatefornoncanonicalubiquitination AT shaliniiyer legionellaeffectormavctargetstheube2nubconjugatefornoncanonicalubiquitination AT jiaqifu legionellaeffectormavctargetstheube2nubconjugatefornoncanonicalubiquitination AT sebastiankenny legionellaeffectormavctargetstheube2nubconjugatefornoncanonicalubiquitination AT kristosinegronteron legionellaeffectormavctargetstheube2nubconjugatefornoncanonicalubiquitination AT zhaoqingluo legionellaeffectormavctargetstheube2nubconjugatefornoncanonicalubiquitination AT petersbrzovic legionellaeffectormavctargetstheube2nubconjugatefornoncanonicalubiquitination AT racheleklevit legionellaeffectormavctargetstheube2nubconjugatefornoncanonicalubiquitination AT chittaranjandas legionellaeffectormavctargetstheube2nubconjugatefornoncanonicalubiquitination
_version_	1718385810390122496

Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination

Ejemplares similares