Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium

Oestrogen receptors α (ERα) are expressed in a subset of mammary epithelial cells. Here, the authors identify cells with low-ERα protein levels and show that distinct cell populations have distinct requirements for the AF1 and AF2 domains of the ERα, and ERα acts in a biphasic manner dependent on de...

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Autores principales:	Stéphanie Cagnet, Dalya Ataca, George Sflomos, Patrick Aouad, Sonia Schuepbach-Mallepell, Henry Hugues, Andrée Krust, Ayyakkannu Ayyanan, Valentina Scabia, Cathrin Brisken
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/648ebe25ccab4e248c751792d692bd28
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spelling	oai:doaj.org-article:648ebe25ccab4e248c751792d692bd282021-12-02T17:32:00ZOestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium10.1038/s41467-018-07175-02041-1723https://doaj.org/article/648ebe25ccab4e248c751792d692bd282018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07175-0https://doaj.org/toc/2041-1723Oestrogen receptors α (ERα) are expressed in a subset of mammary epithelial cells. Here, the authors identify cells with low-ERα protein levels and show that distinct cell populations have distinct requirements for the AF1 and AF2 domains of the ERα, and ERα acts in a biphasic manner dependent on developmental stage.Stéphanie CagnetDalya AtacaGeorge SflomosPatrick AouadSonia Schuepbach-MallepellHenry HuguesAndrée KrustAyyakkannu AyyananValentina ScabiaCathrin BriskenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stéphanie Cagnet Dalya Ataca George Sflomos Patrick Aouad Sonia Schuepbach-Mallepell Henry Hugues Andrée Krust Ayyakkannu Ayyanan Valentina Scabia Cathrin Brisken Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium
description	Oestrogen receptors α (ERα) are expressed in a subset of mammary epithelial cells. Here, the authors identify cells with low-ERα protein levels and show that distinct cell populations have distinct requirements for the AF1 and AF2 domains of the ERα, and ERα acts in a biphasic manner dependent on developmental stage.
format	article
author	Stéphanie Cagnet Dalya Ataca George Sflomos Patrick Aouad Sonia Schuepbach-Mallepell Henry Hugues Andrée Krust Ayyakkannu Ayyanan Valentina Scabia Cathrin Brisken
author_facet	Stéphanie Cagnet Dalya Ataca George Sflomos Patrick Aouad Sonia Schuepbach-Mallepell Henry Hugues Andrée Krust Ayyakkannu Ayyanan Valentina Scabia Cathrin Brisken
author_sort	Stéphanie Cagnet
title	Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium
title_short	Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium
title_full	Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium
title_fullStr	Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium
title_full_unstemmed	Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium
title_sort	oestrogen receptor α af-1 and af-2 domains have cell population-specific functions in the mammary epithelium
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/648ebe25ccab4e248c751792d692bd28
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Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium

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