Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis

Evidence of copper’s (Cu) involvement in Alzheimer’s disease (AD) is available, but information on Cu involvement in microglia and astrocytes during the course of AD has yet to be structurally discussed. This review deals with this matter in an attempt to provide an updated discussion on the role of...

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Autores principales:	Amit Pal, Isha Rani, Anil Pawar, Mario Picozza, Mauro Rongioletti, Rosanna Squitti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	astrocyte microglia copper Alzheimer’s disease Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/649011c6b4454d59a746db7045569c20
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spelling	oai:doaj.org-article:649011c6b4454d59a746db7045569c202021-11-25T16:52:39ZMicroglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis10.3390/biom111115982218-273Xhttps://doaj.org/article/649011c6b4454d59a746db7045569c202021-10-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1598https://doaj.org/toc/2218-273XEvidence of copper’s (Cu) involvement in Alzheimer’s disease (AD) is available, but information on Cu involvement in microglia and astrocytes during the course of AD has yet to be structurally discussed. This review deals with this matter in an attempt to provide an updated discussion on the role of reactive glia challenged by excess labile Cu in a wide picture that embraces all the major processes identified as playing a role in toxicity induced by an imbalance of Cu in AD.Amit PalIsha RaniAnil PawarMario PicozzaMauro RongiolettiRosanna SquittiMDPI AGarticleastrocytemicrogliacopperAlzheimer’s diseaseMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1598, p 1598 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	astrocyte microglia copper Alzheimer’s disease Microbiology QR1-502
spellingShingle	astrocyte microglia copper Alzheimer’s disease Microbiology QR1-502 Amit Pal Isha Rani Anil Pawar Mario Picozza Mauro Rongioletti Rosanna Squitti Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis
description	Evidence of copper’s (Cu) involvement in Alzheimer’s disease (AD) is available, but information on Cu involvement in microglia and astrocytes during the course of AD has yet to be structurally discussed. This review deals with this matter in an attempt to provide an updated discussion on the role of reactive glia challenged by excess labile Cu in a wide picture that embraces all the major processes identified as playing a role in toxicity induced by an imbalance of Cu in AD.
format	article
author	Amit Pal Isha Rani Anil Pawar Mario Picozza Mauro Rongioletti Rosanna Squitti
author_facet	Amit Pal Isha Rani Anil Pawar Mario Picozza Mauro Rongioletti Rosanna Squitti
author_sort	Amit Pal
title	Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis
title_short	Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis
title_full	Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis
title_fullStr	Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis
title_full_unstemmed	Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis
title_sort	microglia and astrocytes in alzheimer’s disease in the context of the aberrant copper homeostasis hypothesis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/649011c6b4454d59a746db7045569c20
work_keys_str_mv	AT amitpal microgliaandastrocytesinalzheimersdiseaseinthecontextoftheaberrantcopperhomeostasishypothesis AT isharani microgliaandastrocytesinalzheimersdiseaseinthecontextoftheaberrantcopperhomeostasishypothesis AT anilpawar microgliaandastrocytesinalzheimersdiseaseinthecontextoftheaberrantcopperhomeostasishypothesis AT mariopicozza microgliaandastrocytesinalzheimersdiseaseinthecontextoftheaberrantcopperhomeostasishypothesis AT maurorongioletti microgliaandastrocytesinalzheimersdiseaseinthecontextoftheaberrantcopperhomeostasishypothesis AT rosannasquitti microgliaandastrocytesinalzheimersdiseaseinthecontextoftheaberrantcopperhomeostasishypothesis
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Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis

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