Viability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosis

To predict outcomes of tuberculosis we investigated the viability of Mycobacterium tuberculosis (MTB) in relation to drug resistance of strains and clinical manifestations of tuberculosis. During the study on solid Löwenstein - Jensen medium, we determined the speed, growth rate and drug resistance...

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Autores principales:	E. Yu. Zorkaltseva, O. A. Vorobyeva, E. D. Savilov, S. N. Shugaeva, V. A. Astafyev
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	tuberculosis the viability of mycobacterium tuberculosis drug resistance hiv-infection Science Q
Acceso en línea:	https://doaj.org/article/64903f7f5a5d4751b704b95b683bfb9a
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spelling	oai:doaj.org-article:64903f7f5a5d4751b704b95b683bfb9a2021-11-23T06:14:38ZViability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosis2541-94202587-959610.12737/article_59e85cb69d5a04.82335815https://doaj.org/article/64903f7f5a5d4751b704b95b683bfb9a2017-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/437https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596To predict outcomes of tuberculosis we investigated the viability of Mycobacterium tuberculosis (MTB) in relation to drug resistance of strains and clinical manifestations of tuberculosis. During the study on solid Löwenstein - Jensen medium, we determined the speed, growth rate and drug resistance of MBT in 5945 cultures, isolated from the sputum of patients with pulmonary tuberculosis - residents of the Irkutsk region (2193 -from newly diagnosed patients, 3752 - from previously treated patients). The criterion of high viability of MBT was the growth rate of >100 colonies over < 30 days, average viability - < 100 colonies over > 20 days; and low viability corresponded with the growth rate of < 20 colonies over > 30 days. 2171 cultures (36.5 %) had high viability of MBT strains, 3021 (50.8 %) - low, and 753 (12.7 %) cultures had average degree of viability. A high degree of pathogen viability was more often determined in newly diagnosed patients with tuberculosis of intrathoracic lymph nodes (all patients with HIV-infection without antiretroviral therapy), fibrotic-cavernous and infiltrative tuberculosis. Among previously treated patients with tuberculosis the high viability of MBT was often determined in patients with fibrous-cavernous and infiltrative tuberculosis, and caseous pneumonia. Cultures from previously treated patients with tuberculosis of intrathoracic lymph nodes had low degree of viability. The number of drug-sensitive strains was 1992, drug-resistant ones - 3953, including 1430 strains with multidrug resistance. We have found that 37.5 % drug-resistant strains associated with a high degree of viability (multidrug resistance - 38.5 %), it's was more often than the drug-sensitive (35.4 %; p < 0.01).E. Yu. ZorkaltsevaO. A. VorobyevaE. D. SavilovS. N. ShugaevaV. A. AstafyevScientific Сentre for Family Health and Human Reproduction Problemsarticletuberculosisthe viability of mycobacterium tuberculosisdrug resistancehiv-infectionScienceQRUActa Biomedica Scientifica, Vol 2, Iss 5(1), Pp 83-87 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	tuberculosis the viability of mycobacterium tuberculosis drug resistance hiv-infection Science Q
spellingShingle	tuberculosis the viability of mycobacterium tuberculosis drug resistance hiv-infection Science Q E. Yu. Zorkaltseva O. A. Vorobyeva E. D. Savilov S. N. Shugaeva V. A. Astafyev Viability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosis
description	To predict outcomes of tuberculosis we investigated the viability of Mycobacterium tuberculosis (MTB) in relation to drug resistance of strains and clinical manifestations of tuberculosis. During the study on solid Löwenstein - Jensen medium, we determined the speed, growth rate and drug resistance of MBT in 5945 cultures, isolated from the sputum of patients with pulmonary tuberculosis - residents of the Irkutsk region (2193 -from newly diagnosed patients, 3752 - from previously treated patients). The criterion of high viability of MBT was the growth rate of >100 colonies over < 30 days, average viability - < 100 colonies over > 20 days; and low viability corresponded with the growth rate of < 20 colonies over > 30 days. 2171 cultures (36.5 %) had high viability of MBT strains, 3021 (50.8 %) - low, and 753 (12.7 %) cultures had average degree of viability. A high degree of pathogen viability was more often determined in newly diagnosed patients with tuberculosis of intrathoracic lymph nodes (all patients with HIV-infection without antiretroviral therapy), fibrotic-cavernous and infiltrative tuberculosis. Among previously treated patients with tuberculosis the high viability of MBT was often determined in patients with fibrous-cavernous and infiltrative tuberculosis, and caseous pneumonia. Cultures from previously treated patients with tuberculosis of intrathoracic lymph nodes had low degree of viability. The number of drug-sensitive strains was 1992, drug-resistant ones - 3953, including 1430 strains with multidrug resistance. We have found that 37.5 % drug-resistant strains associated with a high degree of viability (multidrug resistance - 38.5 %), it's was more often than the drug-sensitive (35.4 %; p < 0.01).
format	article
author	E. Yu. Zorkaltseva O. A. Vorobyeva E. D. Savilov S. N. Shugaeva V. A. Astafyev
author_facet	E. Yu. Zorkaltseva O. A. Vorobyeva E. D. Savilov S. N. Shugaeva V. A. Astafyev
author_sort	E. Yu. Zorkaltseva
title	Viability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosis
title_short	Viability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosis
title_full	Viability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosis
title_fullStr	Viability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosis
title_full_unstemmed	Viability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosis
title_sort	viability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/64903f7f5a5d4751b704b95b683bfb9a
work_keys_str_mv	AT eyuzorkaltseva viabilityofcausativepathogeninpatientswithdrugsensitiveanddrugresistantformsofrespiratorytuberculosis AT oavorobyeva viabilityofcausativepathogeninpatientswithdrugsensitiveanddrugresistantformsofrespiratorytuberculosis AT edsavilov viabilityofcausativepathogeninpatientswithdrugsensitiveanddrugresistantformsofrespiratorytuberculosis AT snshugaeva viabilityofcausativepathogeninpatientswithdrugsensitiveanddrugresistantformsofrespiratorytuberculosis AT vaastafyev viabilityofcausativepathogeninpatientswithdrugsensitiveanddrugresistantformsofrespiratorytuberculosis
_version_	1718417010490081280

Viability of causative pathogen in patients with drug-sensitive and drug-resistant forms of respiratory tuberculosis

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