New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells.

New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells.

Non-steroidal anti-inflammatory drugs such as diclofenac exhibit potent anticancer effects. Up to now these effects were mainly attributed to its classical role as COX-inhibitor. Here we show novel COX-independent effects of diclofenac. Diclofenac significantly diminished MYC expression and modulate...

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Autores principales: Eva Gottfried, Sven A Lang, Kathrin Renner, Anja Bosserhoff, Wolfram Gronwald, Michael Rehli, Sabine Einhell, Isabel Gedig, Katrin Singer, Anton Seilbeck, Andreas Mackensen, Oliver Grauer, Peter Hau, Katja Dettmer, Reinhard Andreesen, Peter J Oefner, Marina Kreutz
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/64919e4e9d61407e8bc01ae34269ec63
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