CdO/CdCO3 nanocomposite physical properties and cytotoxicity against selected breast cancer cell lines

Abstract Cadmium Oxide nanoparticles have the lowest toxicity when compared to nanoparticles of other semiconductors and they are not detrimental to human and mammalian cells, thereby making them candidates for targeting cancer cells. Synadenium cupulare plant extracts were used to synthesize CdO/Cd...

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Autores principales:	R. P. Lefojane, B. T. Sone, N. Matinise, K. Saleh, P. Direko, P. Mfengwana, S. Mashele, M. Maaza, M. P. Sekhoacha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/64930d4410d946e2adb89b7e1cb5249a
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spelling	oai:doaj.org-article:64930d4410d946e2adb89b7e1cb5249a2021-12-02T11:46:06ZCdO/CdCO3 nanocomposite physical properties and cytotoxicity against selected breast cancer cell lines10.1038/s41598-020-78720-52045-2322https://doaj.org/article/64930d4410d946e2adb89b7e1cb5249a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78720-5https://doaj.org/toc/2045-2322Abstract Cadmium Oxide nanoparticles have the lowest toxicity when compared to nanoparticles of other semiconductors and they are not detrimental to human and mammalian cells, thereby making them candidates for targeting cancer cells. Synadenium cupulare plant extracts were used to synthesize CdO/CdCO3 nanocomposite using cadmium nitrate tetrahydrate 98% as a precursor salt. The resultant nanoparticles were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy, ultraviolet visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR). The nanoparticles were then screened for effect on breast cancer cell lines (MCF-7 and MDA MB-231) and Vero cell line to determine their growth inhibition effect. Cytotoxicity effect was evaluated using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. XRD showed the peaks of monteponite CdO and otavite CdCO3 nanoparticles. TEM results showed irregular and spherical particles of varying sizes, whilst SEM revealed a non-uniform morphology. FTIR results showed peaks of functional groups which are present in some of the phytochemical compounds found in S. cupulare, and point to the presence of CdO. Annealed CdO/CdCO3 NPs showed selectivity for MCF7 and MDA MB231 in comparison to Vero cell line, thereby supporting the hypothesis that cadmium oxide nanoparticles inhibit growth of cancerous cells more than non-cancerous cells.R. P. LefojaneB. T. SoneN. MatiniseK. SalehP. DirekoP. MfengwanaS. MasheleM. MaazaM. P. SekhoachaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q R. P. Lefojane B. T. Sone N. Matinise K. Saleh P. Direko P. Mfengwana S. Mashele M. Maaza M. P. Sekhoacha CdO/CdCO3 nanocomposite physical properties and cytotoxicity against selected breast cancer cell lines
description	Abstract Cadmium Oxide nanoparticles have the lowest toxicity when compared to nanoparticles of other semiconductors and they are not detrimental to human and mammalian cells, thereby making them candidates for targeting cancer cells. Synadenium cupulare plant extracts were used to synthesize CdO/CdCO3 nanocomposite using cadmium nitrate tetrahydrate 98% as a precursor salt. The resultant nanoparticles were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy, ultraviolet visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR). The nanoparticles were then screened for effect on breast cancer cell lines (MCF-7 and MDA MB-231) and Vero cell line to determine their growth inhibition effect. Cytotoxicity effect was evaluated using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. XRD showed the peaks of monteponite CdO and otavite CdCO3 nanoparticles. TEM results showed irregular and spherical particles of varying sizes, whilst SEM revealed a non-uniform morphology. FTIR results showed peaks of functional groups which are present in some of the phytochemical compounds found in S. cupulare, and point to the presence of CdO. Annealed CdO/CdCO3 NPs showed selectivity for MCF7 and MDA MB231 in comparison to Vero cell line, thereby supporting the hypothesis that cadmium oxide nanoparticles inhibit growth of cancerous cells more than non-cancerous cells.
format	article
author	R. P. Lefojane B. T. Sone N. Matinise K. Saleh P. Direko P. Mfengwana S. Mashele M. Maaza M. P. Sekhoacha
author_facet	R. P. Lefojane B. T. Sone N. Matinise K. Saleh P. Direko P. Mfengwana S. Mashele M. Maaza M. P. Sekhoacha
author_sort	R. P. Lefojane
title	CdO/CdCO3 nanocomposite physical properties and cytotoxicity against selected breast cancer cell lines
title_short	CdO/CdCO3 nanocomposite physical properties and cytotoxicity against selected breast cancer cell lines
title_full	CdO/CdCO3 nanocomposite physical properties and cytotoxicity against selected breast cancer cell lines
title_fullStr	CdO/CdCO3 nanocomposite physical properties and cytotoxicity against selected breast cancer cell lines
title_full_unstemmed	CdO/CdCO3 nanocomposite physical properties and cytotoxicity against selected breast cancer cell lines
title_sort	cdo/cdco3 nanocomposite physical properties and cytotoxicity against selected breast cancer cell lines
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/64930d4410d946e2adb89b7e1cb5249a
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CdO/CdCO3 nanocomposite physical properties and cytotoxicity against selected breast cancer cell lines

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