Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains

Mechanically stable specific heterodimerization formed with reversible bonds are used as a molecular anchorage in single-molecule force spectroscopy studies with unique mechanical properties. Here authors develop a variety of heterodimerization molecular systems with a range of mechanical stability...

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Auteurs principaux:	Miao Yu, Zhihai Zhao, Zibo Chen, Shimin Le, Jie Yan
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/6493dafac0c14df7a1b27ea21780a881
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id	oai:doaj.org-article:6493dafac0c14df7a1b27ea21780a881
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spelling	oai:doaj.org-article:6493dafac0c14df7a1b27ea21780a8812021-12-02T14:54:28ZModulating mechanical stability of heterodimerization between engineered orthogonal helical domains10.1038/s41467-020-18323-w2041-1723https://doaj.org/article/6493dafac0c14df7a1b27ea21780a8812020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18323-whttps://doaj.org/toc/2041-1723Mechanically stable specific heterodimerization formed with reversible bonds are used as a molecular anchorage in single-molecule force spectroscopy studies with unique mechanical properties. Here authors develop a variety of heterodimerization molecular systems with a range of mechanical stability from a set of recently engineered helix-heterotetramers.Miao YuZhihai ZhaoZibo ChenShimin LeJie YanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Miao Yu Zhihai Zhao Zibo Chen Shimin Le Jie Yan Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains
description	Mechanically stable specific heterodimerization formed with reversible bonds are used as a molecular anchorage in single-molecule force spectroscopy studies with unique mechanical properties. Here authors develop a variety of heterodimerization molecular systems with a range of mechanical stability from a set of recently engineered helix-heterotetramers.
format	article
author	Miao Yu Zhihai Zhao Zibo Chen Shimin Le Jie Yan
author_facet	Miao Yu Zhihai Zhao Zibo Chen Shimin Le Jie Yan
author_sort	Miao Yu
title	Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains
title_short	Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains
title_full	Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains
title_fullStr	Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains
title_full_unstemmed	Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains
title_sort	modulating mechanical stability of heterodimerization between engineered orthogonal helical domains
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6493dafac0c14df7a1b27ea21780a881
work_keys_str_mv	AT miaoyu modulatingmechanicalstabilityofheterodimerizationbetweenengineeredorthogonalhelicaldomains AT zhihaizhao modulatingmechanicalstabilityofheterodimerizationbetweenengineeredorthogonalhelicaldomains AT zibochen modulatingmechanicalstabilityofheterodimerizationbetweenengineeredorthogonalhelicaldomains AT shiminle modulatingmechanicalstabilityofheterodimerizationbetweenengineeredorthogonalhelicaldomains AT jieyan modulatingmechanicalstabilityofheterodimerizationbetweenengineeredorthogonalhelicaldomains
_version_	1718389387951079424

Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains

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