Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains

Mechanically stable specific heterodimerization formed with reversible bonds are used as a molecular anchorage in single-molecule force spectroscopy studies with unique mechanical properties. Here authors develop a variety of heterodimerization molecular systems with a range of mechanical stability...

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Autores principales: Miao Yu, Zhihai Zhao, Zibo Chen, Shimin Le, Jie Yan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/6493dafac0c14df7a1b27ea21780a881
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spelling oai:doaj.org-article:6493dafac0c14df7a1b27ea21780a8812021-12-02T14:54:28ZModulating mechanical stability of heterodimerization between engineered orthogonal helical domains10.1038/s41467-020-18323-w2041-1723https://doaj.org/article/6493dafac0c14df7a1b27ea21780a8812020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18323-whttps://doaj.org/toc/2041-1723Mechanically stable specific heterodimerization formed with reversible bonds are used as a molecular anchorage in single-molecule force spectroscopy studies with unique mechanical properties. Here authors develop a variety of heterodimerization molecular systems with a range of mechanical stability from a set of recently engineered helix-heterotetramers.Miao YuZhihai ZhaoZibo ChenShimin LeJie YanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Miao Yu
Zhihai Zhao
Zibo Chen
Shimin Le
Jie Yan
Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains
description Mechanically stable specific heterodimerization formed with reversible bonds are used as a molecular anchorage in single-molecule force spectroscopy studies with unique mechanical properties. Here authors develop a variety of heterodimerization molecular systems with a range of mechanical stability from a set of recently engineered helix-heterotetramers.
format article
author Miao Yu
Zhihai Zhao
Zibo Chen
Shimin Le
Jie Yan
author_facet Miao Yu
Zhihai Zhao
Zibo Chen
Shimin Le
Jie Yan
author_sort Miao Yu
title Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains
title_short Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains
title_full Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains
title_fullStr Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains
title_full_unstemmed Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains
title_sort modulating mechanical stability of heterodimerization between engineered orthogonal helical domains
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/6493dafac0c14df7a1b27ea21780a881
work_keys_str_mv AT miaoyu modulatingmechanicalstabilityofheterodimerizationbetweenengineeredorthogonalhelicaldomains
AT zhihaizhao modulatingmechanicalstabilityofheterodimerizationbetweenengineeredorthogonalhelicaldomains
AT zibochen modulatingmechanicalstabilityofheterodimerizationbetweenengineeredorthogonalhelicaldomains
AT shiminle modulatingmechanicalstabilityofheterodimerizationbetweenengineeredorthogonalhelicaldomains
AT jieyan modulatingmechanicalstabilityofheterodimerizationbetweenengineeredorthogonalhelicaldomains
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