β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity

During insulin-resistance, the compensatory expansion of beta-cell mass is able to delay or the onset of overt type 2 diabetes. Here, the authors report that beta-arrestin-1, an intracellular protein known to regulate signalling through G protein-coupled receptors, is essential for beta-cell replica...

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Autores principales:	Luiz F. Barella, Mario Rossi, Sai P. Pydi, Jaroslawna Meister, Shanu Jain, Yinghong Cui, Oksana Gavrilova, Gianluca Fulgenzi, Lino Tessarollo, Jürgen Wess
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6495975e0d934f97876f1a64e6b60529
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spelling	oai:doaj.org-article:6495975e0d934f97876f1a64e6b605292021-12-02T17:34:38Zβ-Arrestin-1 is required for adaptive β-cell mass expansion during obesity10.1038/s41467-021-23656-12041-1723https://doaj.org/article/6495975e0d934f97876f1a64e6b605292021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23656-1https://doaj.org/toc/2041-1723During insulin-resistance, the compensatory expansion of beta-cell mass is able to delay or the onset of overt type 2 diabetes. Here, the authors report that beta-arrestin-1, an intracellular protein known to regulate signalling through G protein-coupled receptors, is essential for beta-cell replication and function in insulin-resistant mice.Luiz F. BarellaMario RossiSai P. PydiJaroslawna MeisterShanu JainYinghong CuiOksana GavrilovaGianluca FulgenziLino TessarolloJürgen WessNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luiz F. Barella Mario Rossi Sai P. Pydi Jaroslawna Meister Shanu Jain Yinghong Cui Oksana Gavrilova Gianluca Fulgenzi Lino Tessarollo Jürgen Wess β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity
description	During insulin-resistance, the compensatory expansion of beta-cell mass is able to delay or the onset of overt type 2 diabetes. Here, the authors report that beta-arrestin-1, an intracellular protein known to regulate signalling through G protein-coupled receptors, is essential for beta-cell replication and function in insulin-resistant mice.
format	article
author	Luiz F. Barella Mario Rossi Sai P. Pydi Jaroslawna Meister Shanu Jain Yinghong Cui Oksana Gavrilova Gianluca Fulgenzi Lino Tessarollo Jürgen Wess
author_facet	Luiz F. Barella Mario Rossi Sai P. Pydi Jaroslawna Meister Shanu Jain Yinghong Cui Oksana Gavrilova Gianluca Fulgenzi Lino Tessarollo Jürgen Wess
author_sort	Luiz F. Barella
title	β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity
title_short	β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity
title_full	β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity
title_fullStr	β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity
title_full_unstemmed	β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity
title_sort	β-arrestin-1 is required for adaptive β-cell mass expansion during obesity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6495975e0d934f97876f1a64e6b60529
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β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity

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