Autoantibody as markers of the heart state in patients with vibration disease burdened diabetes mellitus

Physical and chemical factors, obesity, lipid metabolism disorder, diabetes affect the state of the vascular endothelium, the processes of thrombus formation, fibrinolysis and increase the risk of developing cardiovascular diseases. It can be assumed that the development and course of pathological p...

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Autores principales:	L. B. Masnavieva, I. V. Kudaeva, Yu. A. Kuznetsova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2020
Materias:	autoantibodies vibration disease diabetes cardiovascular system heart p1-adrenergic receptor Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/64971de9301f4dc9a13d45de2797d203
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spelling	oai:doaj.org-article:64971de9301f4dc9a13d45de2797d2032021-11-18T08:03:49ZAutoantibody as markers of the heart state in patients with vibration disease burdened diabetes mellitus1563-06252313-741X10.15789/1563-0625-AAM-1739https://doaj.org/article/64971de9301f4dc9a13d45de2797d2032020-04-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1739https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XPhysical and chemical factors, obesity, lipid metabolism disorder, diabetes affect the state of the vascular endothelium, the processes of thrombus formation, fibrinolysis and increase the risk of developing cardiovascular diseases. It can be assumed that the development and course of pathological processes in the cardiovascular system, caused by vibration disease with the onset of diabetes, will undergo changes. The purpose of the study was to assess the state of heart condition according to the level of specific autoantibodies with the combined effect of vibration disease and type 2 diabetes mellitus. Patients with vibration disease (group I), patients with type 2 diabetes (group II) and persons with vibration disease in combination with type 2 diabetes (group III) were examined. Individuals do not have a history of coronary heart disease, stroke, and myocardial infarction have been included in obsledrovanie. Serum levels of specific autoantibodies characterizing the state of the heart have been studied. It was revealed that the content of autoantibodies to 1-adrenoreceptors in patients of group I was higher than in individuals of group II. The relative content of autoantibodies to the components of the membrane and cytoplasm of myocardial cells in patients of groups I-III did not differ. It was found that elevated levels of autoantibodies to components of the membrane and cytoplasm of myocardial cells, cardiomyosin, 1-adrenoreceptors were observed more often in patients with vibration disease combined with diabetes and in persons with vibration disease than in people with diabetes. Persons with a reduced content of autoantibodies to 1-adrenergic receptors were not detected among patients of groups I and III. Changes in the levels of specific autoantibodies in persons with vibration disease may indicate the development of functional metabolic and structural changes in the heart, disorders of its electrical activity that have not yet been manifested in the form of a pathological process. Lower levels of 1-adrenoceptor autoantibodies in patients with type 2 diabetes without vibration disease can be caused by increased levels of catecholamines, which is characteristic of diabetics. Further research, including clinical data and indicators of functional diagnostics is necessary to confirm our assumptions.L. B. MasnavievaI. V. KudaevaYu. A. KuznetsovaSPb RAACIarticleautoantibodiesvibration diseasediabetescardiovascular systemheartp1-adrenergic receptorImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 22, Iss 2, Pp 311-318 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	autoantibodies vibration disease diabetes cardiovascular system heart p1-adrenergic receptor Immunologic diseases. Allergy RC581-607
spellingShingle	autoantibodies vibration disease diabetes cardiovascular system heart p1-adrenergic receptor Immunologic diseases. Allergy RC581-607 L. B. Masnavieva I. V. Kudaeva Yu. A. Kuznetsova Autoantibody as markers of the heart state in patients with vibration disease burdened diabetes mellitus
description	Physical and chemical factors, obesity, lipid metabolism disorder, diabetes affect the state of the vascular endothelium, the processes of thrombus formation, fibrinolysis and increase the risk of developing cardiovascular diseases. It can be assumed that the development and course of pathological processes in the cardiovascular system, caused by vibration disease with the onset of diabetes, will undergo changes. The purpose of the study was to assess the state of heart condition according to the level of specific autoantibodies with the combined effect of vibration disease and type 2 diabetes mellitus. Patients with vibration disease (group I), patients with type 2 diabetes (group II) and persons with vibration disease in combination with type 2 diabetes (group III) were examined. Individuals do not have a history of coronary heart disease, stroke, and myocardial infarction have been included in obsledrovanie. Serum levels of specific autoantibodies characterizing the state of the heart have been studied. It was revealed that the content of autoantibodies to 1-adrenoreceptors in patients of group I was higher than in individuals of group II. The relative content of autoantibodies to the components of the membrane and cytoplasm of myocardial cells in patients of groups I-III did not differ. It was found that elevated levels of autoantibodies to components of the membrane and cytoplasm of myocardial cells, cardiomyosin, 1-adrenoreceptors were observed more often in patients with vibration disease combined with diabetes and in persons with vibration disease than in people with diabetes. Persons with a reduced content of autoantibodies to 1-adrenergic receptors were not detected among patients of groups I and III. Changes in the levels of specific autoantibodies in persons with vibration disease may indicate the development of functional metabolic and structural changes in the heart, disorders of its electrical activity that have not yet been manifested in the form of a pathological process. Lower levels of 1-adrenoceptor autoantibodies in patients with type 2 diabetes without vibration disease can be caused by increased levels of catecholamines, which is characteristic of diabetics. Further research, including clinical data and indicators of functional diagnostics is necessary to confirm our assumptions.
format	article
author	L. B. Masnavieva I. V. Kudaeva Yu. A. Kuznetsova
author_facet	L. B. Masnavieva I. V. Kudaeva Yu. A. Kuznetsova
author_sort	L. B. Masnavieva
title	Autoantibody as markers of the heart state in patients with vibration disease burdened diabetes mellitus
title_short	Autoantibody as markers of the heart state in patients with vibration disease burdened diabetes mellitus
title_full	Autoantibody as markers of the heart state in patients with vibration disease burdened diabetes mellitus
title_fullStr	Autoantibody as markers of the heart state in patients with vibration disease burdened diabetes mellitus
title_full_unstemmed	Autoantibody as markers of the heart state in patients with vibration disease burdened diabetes mellitus
title_sort	autoantibody as markers of the heart state in patients with vibration disease burdened diabetes mellitus
publisher	SPb RAACI
publishDate	2020
url	https://doaj.org/article/64971de9301f4dc9a13d45de2797d203
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Autoantibody as markers of the heart state in patients with vibration disease burdened diabetes mellitus

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