Corneal imaging and densitometry measurements in keratoconus patients to monitor disease progression and treatment outcomes after contact lens or Intacs treatment
Khaled Alzahrani,1,2 Cristina Cristian,3 Sophie Harper,3 Fiona Carley,3 Arun Brahma,3 Debbie Morley,3 M Chantal Hillarby1 1Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Manchester, UK; 2Ophthalmology Department, King Fahad Armed Forces Hospital, Jeddah, Sa...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2018
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/649820bc52b941b69cba6cde90a0c69a |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:649820bc52b941b69cba6cde90a0c69a |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:649820bc52b941b69cba6cde90a0c69a2021-12-02T04:47:47ZCorneal imaging and densitometry measurements in keratoconus patients to monitor disease progression and treatment outcomes after contact lens or Intacs treatment1177-5483https://doaj.org/article/649820bc52b941b69cba6cde90a0c69a2018-09-01T00:00:00Zhttps://www.dovepress.com/corneal-imaging-and-densitometry-measurements-in-keratoconus-patients--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Khaled Alzahrani,1,2 Cristina Cristian,3 Sophie Harper,3 Fiona Carley,3 Arun Brahma,3 Debbie Morley,3 M Chantal Hillarby1 1Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Manchester, UK; 2Ophthalmology Department, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia; 3Manchester Royal Eye Hospital, Manchester, UK Aim: The aim of this study was to compare the pre- and posttreatment corneal densitometry and corneal thickness value of keratoconus (KCN) patients managed via contact lenses (CLs) or by both intrastromal corneal rings and contact lenses.Patients and methods: This prospective study was performed at the Manchester Royal Eye Hospital, UK. Patients were recruited before treatment and followed up for 12 months. Data of corneal densitometry and corneal thickness were collected using the Oculus Pentacam at the pretreatment visit and posttreatment visit at 12 months.Results: Corneal clarity significantly differs between both groups at pre treatment at zone 0–2 mm for the anterior layer (P=0.002). The same diversity is present at zone 2–6 mm for the anterior layer (P=0.003) and posterior layer (P=0.008). The corneal clarity diversity found was not statistically significant at 12 months post treatment (P>0.05). Corneal thickness was found to be statistically significantly different between pre treatment and post treatment for the CL group for central corneal thickness (CCT) and thinnest area (P=0.01 and P=0.02), respectively.Discussion: This study shows that KCN management with Intacs was found to be effective in maintaining corneal clarity for a longer time than that with CL alone. On the other hand, corneal clarity reduces with disease progression in cases managed with CLs only. Analysis of Oculus Pentacam images provides an objective evaluation to monitor the corneal status after these different pathways of management. Keywords: keratoconus, contact lenses, densitometry, Intacs, keratocyte, hazeAlzahrani KCristian CHarper SCarley FBrahma AMorley DHillarby MCDove Medical PressarticleKeratoconusContact LensesDensitometryINTACSKeratocyteHazeOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1653-1658 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Keratoconus Contact Lenses Densitometry INTACS Keratocyte Haze Ophthalmology RE1-994 |
| spellingShingle |
Keratoconus Contact Lenses Densitometry INTACS Keratocyte Haze Ophthalmology RE1-994 Alzahrani K Cristian C Harper S Carley F Brahma A Morley D Hillarby MC Corneal imaging and densitometry measurements in keratoconus patients to monitor disease progression and treatment outcomes after contact lens or Intacs treatment |
| description |
Khaled Alzahrani,1,2 Cristina Cristian,3 Sophie Harper,3 Fiona Carley,3 Arun Brahma,3 Debbie Morley,3 M Chantal Hillarby1 1Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Manchester, UK; 2Ophthalmology Department, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia; 3Manchester Royal Eye Hospital, Manchester, UK Aim: The aim of this study was to compare the pre- and posttreatment corneal densitometry and corneal thickness value of keratoconus (KCN) patients managed via contact lenses (CLs) or by both intrastromal corneal rings and contact lenses.Patients and methods: This prospective study was performed at the Manchester Royal Eye Hospital, UK. Patients were recruited before treatment and followed up for 12 months. Data of corneal densitometry and corneal thickness were collected using the Oculus Pentacam at the pretreatment visit and posttreatment visit at 12 months.Results: Corneal clarity significantly differs between both groups at pre treatment at zone 0–2 mm for the anterior layer (P=0.002). The same diversity is present at zone 2–6 mm for the anterior layer (P=0.003) and posterior layer (P=0.008). The corneal clarity diversity found was not statistically significant at 12 months post treatment (P>0.05). Corneal thickness was found to be statistically significantly different between pre treatment and post treatment for the CL group for central corneal thickness (CCT) and thinnest area (P=0.01 and P=0.02), respectively.Discussion: This study shows that KCN management with Intacs was found to be effective in maintaining corneal clarity for a longer time than that with CL alone. On the other hand, corneal clarity reduces with disease progression in cases managed with CLs only. Analysis of Oculus Pentacam images provides an objective evaluation to monitor the corneal status after these different pathways of management. Keywords: keratoconus, contact lenses, densitometry, Intacs, keratocyte, haze |
| format |
article |
| author |
Alzahrani K Cristian C Harper S Carley F Brahma A Morley D Hillarby MC |
| author_facet |
Alzahrani K Cristian C Harper S Carley F Brahma A Morley D Hillarby MC |
| author_sort |
Alzahrani K |
| title |
Corneal imaging and densitometry measurements in keratoconus patients to monitor disease progression and treatment outcomes after contact lens or Intacs treatment |
| title_short |
Corneal imaging and densitometry measurements in keratoconus patients to monitor disease progression and treatment outcomes after contact lens or Intacs treatment |
| title_full |
Corneal imaging and densitometry measurements in keratoconus patients to monitor disease progression and treatment outcomes after contact lens or Intacs treatment |
| title_fullStr |
Corneal imaging and densitometry measurements in keratoconus patients to monitor disease progression and treatment outcomes after contact lens or Intacs treatment |
| title_full_unstemmed |
Corneal imaging and densitometry measurements in keratoconus patients to monitor disease progression and treatment outcomes after contact lens or Intacs treatment |
| title_sort |
corneal imaging and densitometry measurements in keratoconus patients to monitor disease progression and treatment outcomes after contact lens or intacs treatment |
| publisher |
Dove Medical Press |
| publishDate |
2018 |
| url |
https://doaj.org/article/649820bc52b941b69cba6cde90a0c69a |
| work_keys_str_mv |
AT alzahranik cornealimaginganddensitometrymeasurementsinkeratoconuspatientstomonitordiseaseprogressionandtreatmentoutcomesaftercontactlensorintacstreatment AT cristianc cornealimaginganddensitometrymeasurementsinkeratoconuspatientstomonitordiseaseprogressionandtreatmentoutcomesaftercontactlensorintacstreatment AT harpers cornealimaginganddensitometrymeasurementsinkeratoconuspatientstomonitordiseaseprogressionandtreatmentoutcomesaftercontactlensorintacstreatment AT carleyf cornealimaginganddensitometrymeasurementsinkeratoconuspatientstomonitordiseaseprogressionandtreatmentoutcomesaftercontactlensorintacstreatment AT brahmaa cornealimaginganddensitometrymeasurementsinkeratoconuspatientstomonitordiseaseprogressionandtreatmentoutcomesaftercontactlensorintacstreatment AT morleyd cornealimaginganddensitometrymeasurementsinkeratoconuspatientstomonitordiseaseprogressionandtreatmentoutcomesaftercontactlensorintacstreatment AT hillarbymc cornealimaginganddensitometrymeasurementsinkeratoconuspatientstomonitordiseaseprogressionandtreatmentoutcomesaftercontactlensorintacstreatment |
| _version_ |
1718401008999071744 |