Changes of Brain Functional Connectivity in End-Stage Renal Disease Patients Receiving Peritoneal Dialysis Without Cognitive Decline
Background: Functional connectivity detected by resting-state functional MRI (R-fMRI) helps to discover the subtle changes in brain activities. Patients with end-stage renal disease (ESRD) on hemodialysis (HD) have impaired brain networks. However, the functional changes of brain networks in patient...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/649a82ef42ce4f77a03a41afd63318c1 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:649a82ef42ce4f77a03a41afd63318c1 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:649a82ef42ce4f77a03a41afd63318c12021-11-30T17:59:26ZChanges of Brain Functional Connectivity in End-Stage Renal Disease Patients Receiving Peritoneal Dialysis Without Cognitive Decline2296-858X10.3389/fmed.2021.734410https://doaj.org/article/649a82ef42ce4f77a03a41afd63318c12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.734410/fullhttps://doaj.org/toc/2296-858XBackground: Functional connectivity detected by resting-state functional MRI (R-fMRI) helps to discover the subtle changes in brain activities. Patients with end-stage renal disease (ESRD) on hemodialysis (HD) have impaired brain networks. However, the functional changes of brain networks in patients with ESRD undergoing peritoneal dialysis (PD) have not been fully delineated, especially among those with preserved cognitive function. Therefore, it is worth knowing about the brain functional connectivity in patients with PD by using R-fMRI.Methods: This case-control study prospectively enrolled 19 patients with ESRD receiving PD and 24 age- and sex- matched controls. All participants without a history of cognitive decline received mini-mental status examination (MMSE) and brain 3-T R-fMRI. Comprehensive R-fMRI analyses included graph analysis for connectivity and seed-based correlation networks. Independent t-tests were used for comparing the graph parameters and connectivity networks between patients with PD and controls.Results: All subjects were cognitively intact (MMSE > 24). Whole-brain connectivity by graph analysis revealed significant differences between the two groups with decreased global efficiency (Eglob, p < 0.05), increased betweenness centrality (BC) (p < 0.01), and increased characteristic path length (L, p < 0.01) in patients with PD. The functional connections of the default-mode network (DMN), sensorimotor network (SMN), salience network (SN), and hippocampal network (HN) were impaired in patients with PD. Meanwhile, in DMN and SN, elevated connectivity was observed in certain brain regions of patients with PD.Conclusion: Patients with ESRD receiving PD had specific disruptions in functional connectivity. In graph analysis, Eglob, BC, and L showed significant connectivity changes compared to the controls. DMN and SN had the most prominent alterations among the observed networks, with both decreased and increased connectivity regions. Our study confirmed that significant changes in cerebral connections existed in cognitively intact patients with PD.Ting-Yu ChangHsin-Hsu WuHsin-Hsu WuYi-Jung LiYi-Jung LiHo-Ling LiuChih-Hua YehHui-Shan JianKuo-Lun HuangTsong-Hai LeeYa-Chung TianYa-Chung TianChangwei W. WuChangwei W. WuFrontiers Media S.A.articleend-stage renal diseaseperitoneal dialysisresting-state functional MRIfunctional connectivitygraph theorydefault-mode networkMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
end-stage renal disease peritoneal dialysis resting-state functional MRI functional connectivity graph theory default-mode network Medicine (General) R5-920 |
| spellingShingle |
end-stage renal disease peritoneal dialysis resting-state functional MRI functional connectivity graph theory default-mode network Medicine (General) R5-920 Ting-Yu Chang Hsin-Hsu Wu Hsin-Hsu Wu Yi-Jung Li Yi-Jung Li Ho-Ling Liu Chih-Hua Yeh Hui-Shan Jian Kuo-Lun Huang Tsong-Hai Lee Ya-Chung Tian Ya-Chung Tian Changwei W. Wu Changwei W. Wu Changes of Brain Functional Connectivity in End-Stage Renal Disease Patients Receiving Peritoneal Dialysis Without Cognitive Decline |
| description |
Background: Functional connectivity detected by resting-state functional MRI (R-fMRI) helps to discover the subtle changes in brain activities. Patients with end-stage renal disease (ESRD) on hemodialysis (HD) have impaired brain networks. However, the functional changes of brain networks in patients with ESRD undergoing peritoneal dialysis (PD) have not been fully delineated, especially among those with preserved cognitive function. Therefore, it is worth knowing about the brain functional connectivity in patients with PD by using R-fMRI.Methods: This case-control study prospectively enrolled 19 patients with ESRD receiving PD and 24 age- and sex- matched controls. All participants without a history of cognitive decline received mini-mental status examination (MMSE) and brain 3-T R-fMRI. Comprehensive R-fMRI analyses included graph analysis for connectivity and seed-based correlation networks. Independent t-tests were used for comparing the graph parameters and connectivity networks between patients with PD and controls.Results: All subjects were cognitively intact (MMSE > 24). Whole-brain connectivity by graph analysis revealed significant differences between the two groups with decreased global efficiency (Eglob, p < 0.05), increased betweenness centrality (BC) (p < 0.01), and increased characteristic path length (L, p < 0.01) in patients with PD. The functional connections of the default-mode network (DMN), sensorimotor network (SMN), salience network (SN), and hippocampal network (HN) were impaired in patients with PD. Meanwhile, in DMN and SN, elevated connectivity was observed in certain brain regions of patients with PD.Conclusion: Patients with ESRD receiving PD had specific disruptions in functional connectivity. In graph analysis, Eglob, BC, and L showed significant connectivity changes compared to the controls. DMN and SN had the most prominent alterations among the observed networks, with both decreased and increased connectivity regions. Our study confirmed that significant changes in cerebral connections existed in cognitively intact patients with PD. |
| format |
article |
| author |
Ting-Yu Chang Hsin-Hsu Wu Hsin-Hsu Wu Yi-Jung Li Yi-Jung Li Ho-Ling Liu Chih-Hua Yeh Hui-Shan Jian Kuo-Lun Huang Tsong-Hai Lee Ya-Chung Tian Ya-Chung Tian Changwei W. Wu Changwei W. Wu |
| author_facet |
Ting-Yu Chang Hsin-Hsu Wu Hsin-Hsu Wu Yi-Jung Li Yi-Jung Li Ho-Ling Liu Chih-Hua Yeh Hui-Shan Jian Kuo-Lun Huang Tsong-Hai Lee Ya-Chung Tian Ya-Chung Tian Changwei W. Wu Changwei W. Wu |
| author_sort |
Ting-Yu Chang |
| title |
Changes of Brain Functional Connectivity in End-Stage Renal Disease Patients Receiving Peritoneal Dialysis Without Cognitive Decline |
| title_short |
Changes of Brain Functional Connectivity in End-Stage Renal Disease Patients Receiving Peritoneal Dialysis Without Cognitive Decline |
| title_full |
Changes of Brain Functional Connectivity in End-Stage Renal Disease Patients Receiving Peritoneal Dialysis Without Cognitive Decline |
| title_fullStr |
Changes of Brain Functional Connectivity in End-Stage Renal Disease Patients Receiving Peritoneal Dialysis Without Cognitive Decline |
| title_full_unstemmed |
Changes of Brain Functional Connectivity in End-Stage Renal Disease Patients Receiving Peritoneal Dialysis Without Cognitive Decline |
| title_sort |
changes of brain functional connectivity in end-stage renal disease patients receiving peritoneal dialysis without cognitive decline |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/649a82ef42ce4f77a03a41afd63318c1 |
| work_keys_str_mv |
AT tingyuchang changesofbrainfunctionalconnectivityinendstagerenaldiseasepatientsreceivingperitonealdialysiswithoutcognitivedecline AT hsinhsuwu changesofbrainfunctionalconnectivityinendstagerenaldiseasepatientsreceivingperitonealdialysiswithoutcognitivedecline AT hsinhsuwu changesofbrainfunctionalconnectivityinendstagerenaldiseasepatientsreceivingperitonealdialysiswithoutcognitivedecline AT yijungli changesofbrainfunctionalconnectivityinendstagerenaldiseasepatientsreceivingperitonealdialysiswithoutcognitivedecline AT yijungli changesofbrainfunctionalconnectivityinendstagerenaldiseasepatientsreceivingperitonealdialysiswithoutcognitivedecline AT holingliu changesofbrainfunctionalconnectivityinendstagerenaldiseasepatientsreceivingperitonealdialysiswithoutcognitivedecline AT chihhuayeh changesofbrainfunctionalconnectivityinendstagerenaldiseasepatientsreceivingperitonealdialysiswithoutcognitivedecline AT huishanjian changesofbrainfunctionalconnectivityinendstagerenaldiseasepatientsreceivingperitonealdialysiswithoutcognitivedecline AT kuolunhuang changesofbrainfunctionalconnectivityinendstagerenaldiseasepatientsreceivingperitonealdialysiswithoutcognitivedecline AT tsonghailee changesofbrainfunctionalconnectivityinendstagerenaldiseasepatientsreceivingperitonealdialysiswithoutcognitivedecline AT yachungtian changesofbrainfunctionalconnectivityinendstagerenaldiseasepatientsreceivingperitonealdialysiswithoutcognitivedecline AT yachungtian changesofbrainfunctionalconnectivityinendstagerenaldiseasepatientsreceivingperitonealdialysiswithoutcognitivedecline AT changweiwwu changesofbrainfunctionalconnectivityinendstagerenaldiseasepatientsreceivingperitonealdialysiswithoutcognitivedecline AT changweiwwu changesofbrainfunctionalconnectivityinendstagerenaldiseasepatientsreceivingperitonealdialysiswithoutcognitivedecline |
| _version_ |
1718406383280324608 |